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C. Sakanaka, J. Weiss, L. Williams (1998)
Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcriptionProceedings of the National Academy of Sciences of the United States of America, 95
Roel Nusse, Harold Varmus (1992)
Wnt genesCell, 69
Roel Nusse (1997)
A Versatile Transcriptional Effector of Wingless SignalingCell, 89
Noriko Funayama, François Fagotto, P. McCrea, B. Gumbiner (1995)
Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signalingThe Journal of Cell Biology, 128
B. Rubinfeld, P. Robbins, M. El-Gamil, I. Albert, E. Porfiri, P. Polakis (1997)
Stabilization of beta-catenin by genetic defects in melanoma cell lines.Science, 275 5307
F. Leeuwen, C. Samos, R. Nusse (1994)
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cellsNature, 368
M. Torres, J. Yang-Snyder, S. Purcell, A. Demarais, L. McGrew, R. Moon (1996)
Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus developmentThe Journal of Cell Biology, 133
Min Han (1997)
Gut Reaction to Wnt Signaling in WormsCell, 90
V. Kořínek, Nick Barker, P. Morin, D. Wichen, R. Weger, K. Kinzler, B. Vogelstein, H. Clevers (1997)
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC−/− Colon CarcinomaScience, 275
S. Munemitsu, I. Albert, B. Rubinfeld, P. Polakis (1996)
Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor proteinMolecular and Cellular Biology, 16
C. Sakanaka, J. Weiss, L. Williams (1998)
Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.Proceedings of the National Academy of Sciences of the United States of America, 95 6
E. Siegfried, T. Chou, N. Perrimon (1992)
wingless signaling acts through zeste-white 3, the drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fateCell, 71
D. Stone, M. Hynes, M. Armanini, T. Swanson, Q. Gu, Ronald Johnson, M. Scott, D. Pennica, A. Goddard, H. Phillips, M. Noll, J. Hooper, F. Sauvage, A. Rosenthal (1996)
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehogNature, 384
J. Alcedo, M. Ayzenzon, T. Ohlen, M. Noll, J. Hooper (1996)
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog SignalCell, 86
V. Stambolic, L. Ruel, J. Woodgett (1996)
Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cellsCurrent Biology, 6
A. Barth, I. Näthke, W. Nelson (1997)
Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.Current opinion in cell biology, 9 5
Songyang Zhou, A. Fanning, C. Fu, Jian Xu, S. Marfatia, A. Chishti, A. Crompton, A. Chan, James Anderson, L. Cantley (1997)
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ DomainsScience, 275
D. Strutt, U. Weber, M. Mlodzik (1997)
The role of RhoA in tissue polarity and Frizzled signallingNature, 387
J. Yang-Snyder, Jeffrey Miller, Jeffrey Brown, Cheng-Jung Lai, R. Moon (1996)
A frizzled homolog functions in a vertebrate Wnt signaling pathwayCurrent Biology, 6
R. Moon, Jeffrey Brown, J. Yang-Snyder, Jeffrey Miller (1997)
Structurally Related Receptors and Antagonists Compete for Secreted Wnt LigandsCell, 88
A. Bejsovec, E. Wieschaus (1995)
Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface.Genetics, 139 1
A. Tomlinson, W. Strapps, J. Heemskerk (1997)
Linking Frizzled and Wnt signaling in Drosophila development.Development, 124 22
K. Lin, S. Wang, Martin Julius, J. Kitajewski, M. Moos, F. Luyten (1997)
The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.Proceedings of the National Academy of Sciences of the United States of America, 94 21
K. Cadigan, R. Nusse (1997)
Wnt signaling: a common theme in animal development.Genes & development, 11 24
S. Yanagawa, Jong-seo Lee, Tatsuya Haruna, H. Oda, T. Uemura, M. Takeichi, A. Ishimoto (1997)
Accumulation of Armadillo Induced by Wingless, Dishevelled, and Dominant-negative Zeste-white 3 Leads to Elevated DE-cadherin inDrosophila Clone 8 Wing Disc Cells*The Journal of Biological Chemistry, 272
C. Neumann, S. Cohen (1997)
Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing.Development, 124 4
C. Cabrera, M. Alonso, P. Johnston, R. Phillips, P. Lawrence (1987)
Phenocopies induced with antisense RNA identify the wingless geneCell, 50
Yu Chen, G. Struhl (1996)
Dual Roles for Patched in Sequestering and Transducing HedgehogCell, 87
J. Kitajewski, J. Mason, H. Varmus (1992)
Interaction of Wnt-1 proteins with the binding protein BiPMolecular and Cellular Biology, 12
H. Sawa, Leslie Lobel, H. Horvitz (1996)
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.Genes & development, 10 17
Limin Zheng, Jianjun Zhang, R. Carthew (1995)
frizzled regulates mirror-symmetric pattern formation in the Drosophila eye.Development, 121 9
K. Cadigan, M. Fish, Eric Rulifson, R. Nusse (1998)
Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the WingCell, 93
B. Rubinfeld, B. Souza, I. Albert, O. Müller, S. Chamberlain, F. Masiarz, S. Munemitsu, P. Polakis (1993)
Association of the APC gene product with beta-catenin.Science, 262 5140
M. Molenaar, M. Wetering, M. Oosterwegel, J. Peterson-Maduro, S. Godsave, V. Kořínek, J. Roose, O. Destrée, H. Clevers (1996)
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus EmbryosCell, 86
H. Aberle, A. Bauer, J. Stappert, A. Kispert, R. Kemler (1997)
beta-catenin is a target for the ubiquitin-proteasome pathway.The EMBO journal, 16 13
N. Perrimon (1994)
The genetic basis of patterned baldness in DrosophilaCell, 76
J. Noordermeer, J. Klingensmith, N. Perrimon, R. Nusse (1994)
dishevelled and armadillo act in the Wingless signalling pathway in DrosophilaNature, 367
R. Cavallo, D. Rubenstein, M. Peifer (1997)
Armadillo and dTCF: a marriage made in the nucleus.Current opinion in genetics & development, 7 4
Myriam Zecca, K. Basler, G. Struhl (1996)
Direct and Long-Range Action of a Wingless Morphogen GradientCell, 87
J. Axelrod, K. Matsuno, S. Artavanis-Tsakonas, N. Perrimon (1996)
Interaction Between Wingless and Notch Signaling Pathways Mediated by DishevelledScience, 271
J. Klingensmith, R. Nusse (1994)
Signaling by wingless in Drosophila.Developmental biology, 166 2
R. Moon, Robert Campbell, J Christian, J Christian, L. McGrew, John Shih, Scott Fraser (1993)
Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.Development, 119 1
B. Riggleman, P. Schedl, E. Wieschaus (1990)
Spatial expression of the Drosophila segment polarity gene armadillo is posttranscriptionally regulated by winglessCell, 63
(1998)
P1: APR/ary P2: ARS/dat QC: ARS/APM T1: ARS August42 Annual Reviews AR066-03 84 WODARZ & NUSSE
M. Brannon, M. Gomperts, L. Sumoy, R. Moon, D. Kimelman (1997)
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus.Genes & development, 11 18
J. Riese, Xiang Yu, A. Munnerlyn, S. Eresh, S. Hsu, R. Grosschedl, M. Bienz (1997)
LEF-1, a Nuclear Factor Coordinating Signaling Inputs from wingless and decapentaplegicCell, 88
J. Couso, S. Bishop, A. Arias (1994)
The wingless signalling pathway and the patterning of the wing margin in Drosophila.Development, 120 3
S. Hayashi, B. Rubinfeld, B. Souza, P. Polakis, E. Wieschaus, A. Levine (1997)
A Drosophila homolog of the tumor suppressor gene adenomatous polyposis coli down-regulates beta-catenin but its zygotic expression is not essential for the regulation of Armadillo.Proceedings of the National Academy of Sciences of the United States of America, 94 1
B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, P. Polakis (1996)
Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex AssemblyScience, 272
B. Rubinfeld, P. Robbins, M. El-Gamil, I. Albert, E. Porfiri, P. Polakis (1997)
Stabilization of β-Catenin by Genetic Defects in Melanoma Cell LinesScience, 275
K. Jones, J. Liu, P. Adler (1996)
Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster.Genetics, 142 1
V. Marigo, R. Davey, Y. Zuo, James Cunningham, C. Tabin (1996)
Biochemical evidence that Patched is the Hedgehog receptorNature, 384
Yanshu Wang, J. Macke, Benjamin Abella, Katrin Andreasson, P. Worley, D. Gilbert, N. Copeland, N. Jenkins, J. Nathans (1996)
A Large Family of Putative Transmembrane Receptors Homologous to the Product of the Drosophila Tissue Polarity Gene frizzled(*)The Journal of Biological Chemistry, 271
M. Heuvel, R. Nusse, P. Johnston, P. Lawrence (1989)
Distribution of the wingless gene product in drosophila embryos: A protein involved in cell-cell communicationCell, 59
M. Baylies, A. Arias, M. Bate (1995)
wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis.Development, 121 11
F. Reichsman, Laurie Smith, S. Cumberledge (1996)
Glycosaminoglycans can modulate extracellular localization of the wingless protein and promote signal transductionThe Journal of Cell Biology, 135
R. Nusse, C. Samos, M. Brink, K. Willert, K. Cadigan, A. Wodarz, M. Fish, E. Rulifson (1997)
Cell culture and whole animal approaches to understanding signaling by Wnt proteins in Drosophila.Cold Spring Harbor symposia on quantitative biology, 62
Stephan Schneider, H. Steinbeisser, R. Warga, P. Hausen (1996)
β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryosMechanisms of Development, 57
M. Wetering, R. Cavallo, D. Dooijes, M. Beest, J. Es, J. Loureiro, Arne Ypma, D. Hursh, T. Jones, A. Bejsovec, M. Peifer, M. Mortin, H. Clevers (1997)
Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCFCell, 88
Shouwen Wang, M. Krinks, Keming Lin, F. Luyten, M. Moos (1997)
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8Cell, 88
D. Doyle, Alice Lee, John Lewis, Eunjoon Kim, M. Sheng, R. MacKinnon (1996)
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZCell, 85
M. Heuvel, P. Ingham (1996)
smoothened encodes a receptor-like serpentine protein required for hedgehog signallingNature, 382
A. McMahon, A. Bradley (1990)
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brainCell, 62
L. Zeng, F. Fagotto, Tong Zhang, W. Hsu, T. Vasicek, W. Perry, James Lee, S. Tilghman, B. Gumbiner, F. Costantini (1997)
The Mouse Fused Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis FormationCell, 90
Bang Hoang, M. Moos, S. Vukicevic, F. Luyten (1996)
Primary Structure and Tissue Distribution of FRZB, a Novel Protein Related to Drosophila Frizzled, Suggest a Role in Skeletal Morphogenesis*The Journal of Biological Chemistry, 271
F. Rijsewijk, M. Schuermann, E. Wagenaar, P. Parren, D. Weigel, R. Nusse (1987)
The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene winglessCell, 50
Stephan Hoppler, Jeffrey Brown, R. Moon (1996)
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Genes & development, 10 21
B. Sanson, P. White, J. Vincent (1996)
Uncoupling cadherin-based adhesion from wingless signalling in DrosophilaNature, 383
O. Huber, R. Korn, J. McLaughlin, M. Ohsugi, B. Herrmann, R. Kemler (1996)
Nuclear localization of β-catenin by interaction with transcription factor LEF-1Mechanisms of Development, 59
S. Sokol, J. Klingensmith, N. Perrimon, K. Itoh (1995)
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.Development, 121 6
Gwendolyn Wong, B. Gavin, A. McMahon (1994)
Differential transformation of mammary epithelial cells by Wnt genesMolecular and Cellular Biology, 14
Jeffrey Miller, R. Moon (1997)
Analysis of the Signaling Activities of Localization Mutants of β-Catenin during Axis Specification in XenopusThe Journal of Cell Biology, 139
K. Itoh, S. Sokol (1994)
Heparan sulfate proteoglycans are required for mesoderm formation in Xenopus embryos.Development, 120 9
R. Nusse, H. Varmus (1982)
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genomeCell, 31
Roger Bradley, Anthony Brown (1990)
The proto‐oncogene int‐1 encodes a secreted protein associated with the extracellular matrix.The EMBO Journal, 9
Jin Jiang, G. Struhl (1998)
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbNature, 391
Shall Jue, Roger Bradley, '. Rudnicki, H. Varmus, C. ANTHONYM., '. Brown (1992)
The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cellsMolecular and Cellular Biology, 12
R. Moon, Jeffrey Brown, Jeffrey Brown, M. Torres (1997)
WNTs modulate cell fate and behavior during vertebrate development.Trends in genetics : TIG, 13 4
J. Behrens, J. Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier (1996)
Functional interaction of beta-catenin with the transcription factor LEF-1.Nature, 382 6592
D. Slusarski, V. Corces, R. Moon (1997)
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signallingNature, 390
(1996)
Deletion of an amino-terminal sequence stabilizes �-catenin in vivo and promotes hyperphosphorylation of the adenomatous polyposis coli tumor suppressor protein
J. Couso, A. Arias (1994)
Notch is required for wingless signaling in the epidermis of DrosophilaCell, 79
H. Aberle, A. Bauer, J. Stappert, A. Kispert, R. Kemler (1997)
β‐catenin is a target for the ubiquitin–proteasome pathwayThe EMBO Journal, 16
P. Bhanot, M. Brink, C. Samos, J. Hsieh, Yanshu Wang, J. Macke, D. Andrew, J. Nathans, R. Nusse (1996)
A new member of the frizzled family from Drosophila functions as a Wingless receptorNature, 382
H. Hing, Xin-Yao Sun, S. Artavanis-Tsakonas (1994)
Modulation of wingless signaling by Notch in DrosophilaMechanisms of Development, 47
P. Adler (1992)
The genetic control of tissue polarity in DrosophilaBioEssays, 14
Xi He, J. Saint-Jeannet, Yanshu Wang, J. Nathans, I. Dawid, H. Varmus (1997)
A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5AScience, 275
B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, P. Polakis (1996)
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.Science, 272 5264
T. Kadowaki, E. Wilder, J. Klingensmith, K. Zachary, N. Perrimon (1996)
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing.Genes & development, 10 24
U. Häcker, Xinhua Lin, N. Perrimon (1997)
The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.Development, 124 18
Finch Pw, X. He, M. Kelley, A. Üren, Schaudies Rp, N. Popescu, S. Rudikoff, S. Aaronson, H. Varmus, J. Rubin (1997)
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.Proceedings of the National Academy of Sciences of the United States of America, 94 13
Kathleen Guger, B. Gumbiner (1995)
beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning.Developmental biology, 172 1
Heidi Theisen, Judith Purcell, M. Bennett, Dipul Kansagara, A. Syed, J. Marsh (1994)
dishevelled is required during wingless signaling to establish both cell polarity and cell identity.Development, 120 2
K. Thomas, M. Capecchi (1990)
Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar developmentNature, 346
E. Siegfried, E. Wilder, N. Perrimon (1994)
Components of wingless signalling in DrosophilaNature, 367
K. Willert, R. Nusse (1998)
β-catenin: a key mediator of Wnt signalingCurrent Opinion in Genetics & Development, 8
S. Munemitsu, I. Albert, B. Souza, B. Rubinfeld, P. Polakis (1995)
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.Proceedings of the National Academy of Sciences of the United States of America, 92
A. Rattner, J. Hsieh, P. Smallwood, D. Gilbert, N. Copeland, N. Jenkins, J. Nathans (1997)
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.Proceedings of the National Academy of Sciences of the United States of America, 94 7
J. Behrens, J. Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier (1996)
Functional interaction of β-catenin with the transcription factor LEF-1Nature, 382
S. Yanagawa, F. Leeuwen, A. Wodarz, J. Klingensmith, R. Nusse (1995)
The dishevelled protein is modified by wingless signaling in Drosophila.Genes & development, 9 9
R. Krasnow, Lily Wong, P. Adler (1995)
Dishevelled is a component of the frizzled signaling pathway in Drosophila.Development, 121 12
S. Sokol (1996)
Analysis of Dishevelled signalling pathways during Xenopus developmentCurrent Biology, 6
Christian Rocheleau, W. Downs, R. Lin, C. Wittmann, Y. Bei, Yoon-Hee Cha, Mussa Ali, J. Priess, C. Mello (1997)
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans EmbryosCell, 90
B. Smolich, J. McMahon, P. ttAndrew, Mcmahon, J. Papkoff (1993)
Wnt family proteins are secreted and associated with the cell surface.Molecular biology of the cell, 4 12
R. Hays, G. Gibori, A. Bejsovec (1997)
Wingless signaling generates pattern through two distinct mechanisms.Development, 124 19
T. Haerry, T. Heslip, J. Marsh, Michael O’Connor (1997)
Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila.Development, 124 16
Ken Cadigan, Roel Nusse (1996)
wingless signaling in the Drosophila eye and embryonic epidermis.Development, 122 9
R. Binari, B. Staveley, W. Johnson, R. Godavarti, R. Sasisekharan, A. Manoukian (1997)
Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling.Development, 124 13
Eric Rulifson, S. Blair (1995)
Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila.Development, 121 9
S. Ikeda, S. Kishida, Hideki Yamamoto, H. Murai, S. Koyama, A. Kikuchi (1998)
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐cateninThe EMBO Journal, 17
I. Dominguez, K. Itoh, S. Sokol (1995)
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.Proceedings of the National Academy of Sciences of the United States of America, 92 18
L. Su, B. Vogelstein, K. Kinzler (1993)
Association of the APC tumor suppressor protein with catenins.Science, 262 5140
C. Vinson, S. Conover, P. Adler (1989)
A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domainsNature, 338
A. McMahon, R. Moon (1989)
Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axisCell, 58
C. Nüsslein-Volhard, E. Wieschaus (1980)
Mutations affecting segment number and polarity in DrosophilaNature, 287
S. Orsulic, M. Peifer (1996)
An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signalingThe Journal of Cell Biology, 134
Xi He, J. Saint-Jeannet, J. Woodgett, H. Varmus, I. Dawid (1995)
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryosNature, 374
T. Mayr, U. Deutsch, M. Kühl, H. Drexler, F. Lottspeich, R. Deutzmann, D. Wedlich, W. Risau (1997)
Fritz: a secreted frizzled-related protein that inhibits Wnt activityMechanisms of Development, 63
E. Brunner, Oliver Peter, L. Schweizer, K. Basler (1997)
pangolinencodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in DrosophilaNature, 385
C. Yost, M. Torres, Jeffrey Miller, Eugene Huang, D. Kimelman, R. Moon (1996)
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Genes & development, 10 12
M. Herman, L. Vassilieva, H. Horvitz, J. Shaw, R. Herman (1995)
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomouslyCell, 83
B. Parr, A. McMahon (1994)
Wnt genes and vertebrate development.Current opinion in genetics & development, 4 4
J. Klingensmith, Roel Nusse, Norbert Perrimon (1994)
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Genes & development, 8 1
(1997)
Frzb-1 is a secreted P1: APR/ary P2
S Du, S Purcell, J Christian, L. McGrew, R. Moon (1995)
Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryosMolecular and Cellular Biology, 15
Yu-Ker Wang, C. Samos, R. Peoples, Luis Pérez-Jurado, R. Nusse, U. Francke (1997)
A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23.Human molecular genetics, 6 3
Marcel Heuvell, C. Harryman-Samos, J. Klingensmith, Norbert Perrimon, Roel Nusse (1993)
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein.The EMBO Journal, 12
J. Heasman, A. Crawford, K. Goldstone, P. Garner-Hamrick, B. Gumbiner, P. McCrea, C. Kintner, C. Noro, C. Wylie (1994)
Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos.Cell, 79 5
K. Willert, M. Brink, A. Wodarz, H. Varmus, R. Nusse (1997)
Casein kinase 2 associates with and phosphorylates DishevelledThe EMBO Journal, 16
C. Vinson, P. Adler (1987)
Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of DrosophilaNature, 329
P. Adler, R. Krasnow, Jingchun Liu (1997)
Tissue polarity points from cells that have higher Frizzled levels towards cells that have lower Frizzled levelsCurrent Biology, 7
L. Leyns, T. Bouwmeester, Sung-Hyun Kim, S. Piccolo, E. Robertis (1997)
Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann OrganizerCell, 88
C. Larabell, M. Torres, B. Rowning, C. Yost, Jeffrey Miller, Mike Wu, D. Kimelman, R. Moon (1997)
Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling PathwayThe Journal of Cell Biology, 136
L. Wong, P. Adler (1993)
Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cellsThe Journal of Cell Biology, 123
C. Ponting, Peer Bork (1996)
Pleckstrin's repeat performance: a novel domain in G-protein signaling?Trends in biochemical sciences, 21 7
M. Peifer, D. Sweeton, Michael Casey, Eric Wieschaus (1994)
wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo.Development, 120 2
S. Ikeda, S. Kishida, H. Yamamoto, H. Murai, S. Koyama, A. Kikuchi (1998)
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.The EMBO journal, 17 5
C. Thorpe, A. Schlesinger, J. Carter, B. Bowerman (1997)
Wnt Signaling Polarizes an Early C. elegans Blastomere to Distinguish Endoderm from MesodermCell, 90
J Christian, R. Moon (1993)
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.Genes & development, 7 1
N. Lijam, R. Paylor, M. McDonald, J. Crawley, C. Deng, K. Herrup, K. Stevens, G. Maccaferri, C. McBain, D. Sussman, A. Wynshaw-Boris (1997)
Social Interaction and Sensorimotor Gating Abnormalities in Mice Lacking Dvl1Cell, 90
(1994)
The genetic basis of P1: APR/ary P2: ARS/dat QC: ARS/APM T1: ARS August 29
L. Pai, S. Orsulic, S. Orsulic, A. Bejsovec, M. Peifer (1997)
Negative regulation of Armadillo, a Wingless effector in Drosophila.Development, 124 11
P. Morin, A. Sparks, V. Kořínek, N. Barker, H. Clevers, B. Vogelstein, K. Kinzler (1997)
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APCScience, 275
N. Goode, K. Hughes, J. Woodgett, P. Parker (1992)
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.The Journal of biological chemistry, 267 24
D. Slusarski, J. Yang-Snyder, W. Busa, R. Moon (1997)
Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A.Developmental biology, 182 1
K. Vleminckx, E. Wong, Kathleen Guger, B. Rubinfeld, P. Polakis, B. Gumbiner (1997)
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior AxisThe Journal of Cell Biology, 136
David Cook, M. Fry, K. Hughes, R. Sumathipala, J. Woodgett, T. Dale (1996)
Wingless inactivates glycogen synthase kinase‐3 via an intracellular signalling pathway which involves a protein kinase C.The EMBO Journal, 15
J. Heasman, A. Crawford, K. Goldstone, P. Garner-Hamrick, B. Gumbiner, P. McCrea, C. Kintner, Chikako Noro, C. Wylie (1994)
Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryosCell, 79
J. Noordermeer, P. Johnston, F. Rijsewijk, R. Nusse, P. Lawrence (1992)
The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo.Development, 116 3
R. Lin, S. Thompson, J. Priess (1995)
pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryosCell, 83
Lindsay Hinck, W. Nelson, Jackie Papkofl (1994)
Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherinThe Journal of Cell Biology, 124
Jackie Papkoff, B. Rubinfeld, Brian Schryver, P. Polakis (1996)
Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexesMolecular and Cellular Biology, 16
J. Sampedro, P. Johnston, Pareena Lawrence (1993)
A role for wingless in the segmental gradient of Drosophila?Development, 117 2
▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in development. Genetic studies in Drosophila and Caenorhabditis elegans , ectopic gene expression in Xenopus , and gene knockouts in the mouse have demonstrated the involvement of Wnts in processes as diverse as segmentation, CNS patterning, and control of asymmetric cell divisions. The transduction of Wnt signals between cells proceeds in a complex series of events including post-translational modification and secretion of Wnts, binding to transmembrane receptors, activation of cytoplasmic effectors, and, finally, transcriptional regulation of target genes. Over the past two years our understanding of Wnt signaling has been substantially improved by the identification of Frizzled proteins as cell surface receptors for Wnts and by the finding that β-catenin, a component downstream of the receptor, can translocate to the nucleus and function as a transcriptional activator. Here we review recent data that have started to unravel the mechanisms of Wnt signaling.
Annual Review of Cell and Developmental Biology – Annual Reviews
Published: Nov 1, 1998
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