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- Publisher
- Springer Journals
- Copyright
- Copyright © 2012 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Life Sciences; Life Sciences, general; Biochemistry, general; Protein Structure; Membrane Biology; Biological Microscopy
- ISSN
- 1545-9993
- eISSN
- 1545-9985
- DOI
- 10.1038/nsmb.2314
- Publisher site
- See Article on Publisher Site
Abstract
LEDGF (p75) is a chromatin-binding protein implicated in cancer, autoimmune disease and HIV-1 pathogenesis, but its cellular function was still unclear. Now LEDGF is found to have a role in the repair of DNA double-stranded breaks via homologous recombination, promoting end resection by CtIP.
Journal
Nature Structural & Molecular Biology – Springer Journals
Published: Jul 8, 2012