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RK Chan, ER Brown, A. Ericsson, K. Kovács, PE Sawchenko (1993)
A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry, 13
J. Kononen, J. Honkaniemi, H. Alho, J. Koistinaho, M. Iadarola, M. Pelto-huikko (1992)
Fos-like immunoreactivity in the rat hypothalamic-pituitary axis after immobilization stress.Endocrinology, 130 5
S. Lin, S. Macleod, J. Hardin (1992)
Effects of glucocorticoids on expression of the fos protooncogene in AtT-20 cells.Endocrinology, 130 1
Kovacs Kovacs, Sawchenko Sawchenko (1996)
Regulation of stress‐induced transcriptional changes in the hypothalamic neurosecretory neuronsJ Mol Neurosci, 7
H. Li, P. Sawchenko (1998)
Hypothalamic effector neurons and extended circuitries activated in “neurogenic” stress: A comparison of footshock effects exerted acutely, chronically, and in animals with controlled glucocorticoid levelsJournal of Comparative Neurology, 393
(2001)
Glucocorticoid receptor agonist RU28362 has no effect on acute stress-induced c-Fos expression in the PVN of the rat
Mark Smith, Su-Yong Kim, H. Oers, S. Levine (1997)
Maternal deprivation and stress induce immediate early genes in the infant rat brain.Endocrinology, 138 11
Xin-ming Ma, A. Levy, S. Lightman (1997)
Rapid changes in heteronuclear RNA for corticotrophin-releasing hormone and arginine vasopressin in response to acute stress.The Journal of endocrinology, 152 1
H. Beyer, S. Matta, Burt Sharp (1988)
Regulation of the messenger ribonucleic acid for corticotropin-releasing factor in the paraventricular nucleus and other brain sites of the rat.Endocrinology, 123 4
P. Larsen, J. Mikkelsen (1995)
Functional identification of central afferent projections conveying information of acute "stress" to the hypothalamic paraventricular nucleus, 15
R. Evans, J. Arriza (1989)
A molecular framework for the actions of glucocorticoid hormones in the nervous systemNeuron, 2
N. Chastrette, D. Pfaff, R. Gibbs (1991)
Effects of daytime and nighttime stress on Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus, the habenula, and the posterior paraventricular nucleus of the thalamusBrain Research, 563
(1083)
1075±1083 RU28362, stress, and gene expression
James Herman, Chantai Prewitt, W. Cullinan (1996)
Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis.Critical reviews in neurobiology, 10 3-4
W. Nicholson, D. Davis, B. Sherrell, D. Orth (1984)
Rapid radioimmunoassay for corticotropin in unextracted human plasma.Clinical chemistry, 30 2
A. Ericsson, K. Kovács, P. Sawchenko (1994)
A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons, 14
W. Cullinan, J. Herman, D. Battaglia, H. Akil, S. Watson (1995)
Pattern and time course of immediate early gene expression in rat brain following acute stressNeuroscience, 64
H. Reichardt, K. Kaestner, J. Tuckermann, O. Kretz, O. Wessely, R. Bock, P. Gass, W. Schmid, P. Herrlich, P. Angel, G. Schütz (1998)
DNA Binding of the Glucocorticoid Receptor Is Not Essential for SurvivalCell, 93
Xin-Ming Ma, S. Lightman, Greti Aguilera (1999)
Vasopressin and corticotropin-releasing hormone gene responses to novel stress in rats adapted to repeated restraint.Endocrinology, 140 8
J. Reul, P. Pearce, J. Funder, Z. Krozowski (1989)
Type I and type II corticosteroid receptor gene expression in the rat: effect of adrenalectomy and dexamethasone administration.Molecular endocrinology, 3 10
C. Bamberger, Heinrich Schulte, G. Chrousos (1996)
Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids.Endocrine reviews, 17 3
T. Imaki, J. Nahan, C. Rivier, P. Sawchenko, W. Vale (1991)
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress, 11
S. Ceccatelli, M. Villar, M. Goldstein, Tomas Hökfelt (1989)
Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress.Proceedings of the National Academy of Sciences of the United States of America, 86 23
J. Veening, M. Meer, Henk Joosten, A. Hermus, C. Rijnkels, L. Geeraedts, C. Sweep (1993)
Intravenous administration of interleukin-1β induces Fos-like immunoreactivity in corticotropin-releasing hormone neurons in the paraventricular hypothalamic nucleus of the ratJournal of Chemical Neuroanatomy, 6
M. Dallman, S. Akana, C. Cascio, D. Darlington, L. Jacobson, N. Levin (1987)
Regulation of ACTH secretion: variations on a theme of B.Recent progress in hormone research, 43
H. Jingami, S. Matsukura, S. Numa, H. Imura (1985)
Effects of adrenalectomy and dexamethasone administration on the level of prepro-corticotropin-releasing factor messenger ribonucleic acid (mRNA) in the hypothalamus and adrenocorticotropin/beta-lipotropin precursor mRNA in the pituitary in rats.Endocrinology, 117 4
K. Kovács, A. Földes, P. Sawchenko (2000)
Glucocorticoid Negative Feedback Selectively Targets Vasopressin Transcription in Parvocellular Neurosecretory NeuronsThe Journal of Neuroscience, 20
K. Kovács (1998)
Functional neuroanatomy of the parvocellular vasopressinergic system: transcriptional responses to stress and glucocorticoid feedback.Progress in brain research, 119
S. Tanimura, A. Watts (2000)
Adrenalectomy Dramatically Modifies the Dynamics of Neuropeptide and c‐fos Gene Responses to Stress in the Hypothalamic Paraventricular NucleusJournal of Neuroendocrinology, 12
L. Jacobson, F. Sharp, M. Dallman (1990)
Induction of fos-like immunoreactivity in hypothalamic corticotropin-releasing factor neurons after adrenalectomy in the rat.Endocrinology, 126 3
K. Laugero, F. Gómez, Sotara Manalo, M. Dallman (2002)
Corticosterone infused intracerebroventricularly inhibits energy storage and stimulates the hypothalamo-pituitary axis in adrenalectomized rats drinking sucrose.Endocrinology, 143 12
S. Akana, L. Jacobson, C. Cascio, J. Shinsako, M. Dallman (1988)
Constant corticosterone replacement normalizes basal adrenocorticotropin (ACTH) but permits sustained ACTH hypersecretion after stress in adrenalectomized rats.Endocrinology, 122 4
R. Sapolsky (1999)
Glucocorticoids, stress, and their adverse neurological effects: relevance to agingExperimental Gerontology, 34
J. Herman, W. Cullinan (1997)
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axisTrends in Neurosciences, 20
E. Kloet, M. Oitzl, M. Joëls (1993)
Functional implications of brain corticosteroid receptor diversityCellular and Molecular Neurobiology, 13
M. Shipston (1995)
Mechanism(s) of early glucocorticoid inhibition of adrenocorticotropin secretion from anterior pituitary corticotropesTrends in Endocrinology & Metabolism, 6
K. Kovács (1998)
Invited review c-Fos as a transcription factor: a stressful (re)view from a functional mapNeurochemistry International, 33
R. Spencer, Brian Kalman, C. Cotter, T. Deak (2000)
Discrimination between changes in glucocorticoid receptor expression and activation in rat brain using western blot analysisBrain Research, 868
C. Watson, B. Gametchu (1999)
Membrane-initiated steroid actions and the proteins that mediate them.Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine, 220 1
Kovacs Kovacs (1998)
c‐Fos as a transcription factor: a stressful (re)view from a functional mapNeurochem Int, 33
L. Jacobson, S. Akana, C. Cascio, J. Shinsako, M. Dallman (1988)
Circadian variations in plasma corticosterone permit normal termination of adrenocorticotropin responses to stress.Endocrinology, 122 4
K. Pacak, Miklós Palkovits, Miklós Palkovits (2001)
Stressor specificity of central neuroendocrine responses: implications for stress-related disorders.Endocrine reviews, 22 4
Watson (1999)
Membrane-initiated steroid actions and the proteins that mediate themProc Soc Exp Biol Med, 220
Xin-Ming Ma, Greti Aguilera (1999)
Differential regulation of corticotropin-releasing hormone and vasopressin transcription by glucocorticoids.Endocrinology, 140 12
B. Hinz, R. Hirschelmann (2000)
Rapid Non-Genomic Feedback Effects of Glucocorticoids on CRF-Induced ACTH Secretion in RatsPharmaceutical Research, 17
T. Imaki, Xiaoqing Wang, Tamotsu Shibasaki, Koji Yamada, S. Harada, N. Chikada, Mitsuhide Naruse, Hiroshi Demura (1995)
Stress-induced activation of neuronal activity and corticotropin-releasing factor gene expression in the paraventricular nucleus is modulated by glucocorticoids in rats.The Journal of clinical investigation, 96 1
S. Watson (1997)
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐fos Induction Associated with Audiogenic StressJournal of Neuroendocrinology, 9
M. Harbuz, D. Jessop (1999)
Dissociation between c-fos mRNA in the paraventricular nucleus and corticosterone secretion in rats with adjuvant-induced arthritis.The Journal of endocrinology, 163 1
M. Shipston, J. Kelly, F. Antoni (1996)
Glucocorticoids Block Protein Kinase A Inhibition of Calcium-activated Potassium Channels (*)The Journal of Biological Chemistry, 271
S. Akana, K. Scribner, M. Bradbury, A. Strack, C. Walker, M. Dallman (1992)
Feedback sensitivity of the rat hypothalamo-pituitary-adrenal axis and its capacity to adjust to exogenous corticosterone.Endocrinology, 131 2
L. Jacobson, R. Sapolsky (1993)
Augmented ACTH responses to stress in adrenalectomized rats replaced with constant, physiological levels of corticosterone are partially normalized by acute increases in corticosterone.Neuroendocrinology, 58 4
D. Helmreich, W. Cullinan, S. Watson (1996)
The effect of adrenalectomy on stress-induced c-fos mRNA expression in the rat brainBrain Research, 706
D. Rotllant, S. Ons, J. Carrasco, A. Armario (2002)
Evidence that metyrapone can act as a stressor: effect on pituitary‐adrenal hormones, plasma glucose and brain c‐fos inductionEuropean Journal of Neuroscience, 16
O. Meijer, E. Lange, D. Breimer, A. Boer, J. Workel, E. Kloet (1998)
Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice.Endocrinology, 139 4
Holger Reichardt, François Tronche, S. Berger, C. Kellendonk, G. Schütz (2000)
New insights into glucocorticoid and mineralocorticoid signaling: lessons from gene targeting.Advances in pharmacology, 47
M. Keller‐Wood, M. Dallman (1984)
Corticosteroid inhibition of ACTH secretion.Endocrine reviews, 5 1
E. Kloet, E. Vreugdenhil, M. Oitzl, M. Joëls (1998)
Brain corticosteroid receptor balance in health and disease.Endocrine reviews, 19 3
S. Tanimura, A. Watts (1998)
Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.Endocrinology, 139 9
J Herman, Martin Schäfer, R. Thompson, Stanley Watson (1992)
Rapid regulation of corticotropin-releasing hormone gene transcription in vivo.Molecular endocrinology, 6 7
L. Swanson, D. Simmons (1989)
Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: A hybridization histochemical study in the ratJournal of Comparative Neurology, 285
S. Yi, J. Masters, T. Baram (1993)
Effects of a specific glucocorticoid receptor antagonist on corticotropin releasing hormone gene expression in the paraventricular nucleus of the neonatal rat.Brain research. Developmental brain research, 73 2
Corticosterone regulates both basal and stress‐induced hypothalamic‐pituitary‐adrenal (HPA) axis activity in a negative‐feedback fashion. However, the cellular and molecular mechanisms of this negative feedback have yet to be explicitly characterized. By comparing stress‐induced c‐fos and corticotropin‐releasing hormone (CRH) expression in the paraventricular nucleus (PVN), we may be able to determine whether acute glucocorticoid treatment affects the net neural excitatory input to the PVN (represented primarily by c‐fos mRNA expression) or directly affects the ability of cells in the PVN to respond to that input (represented primarily by CRH hnRNA expression). In the following studies, we observed the effect of acute glucocorticoid (RU28362) treatment on subsequent HPA axis reactivity by measuring stress‐induced plasma hormone concentration (corticosterone and adrenocorticotropic hormone (ACTH)) and gene expression (c‐fos and CRH) in the PVN. First, we examined the dose–response relationship between systemically administered RU28362 (1–150 µg/kg, i.p) and suppression of the stress‐induced corticosterone response. We then confirmed central nervous system access of the maximally suppressive dose of RU28362 (150 µg/kg) by an ex vivo radioligand binding assay. RU28362 selectively occupied the majority of glucocorticoid receptors in the hippocampus and hypothalamus while having no effect on mineralocorticoid receptors. In separate studies, RU28362 (150 µg/kg) and corticosterone (5 mg/kg) were injected i.p. 1 h before restraint stress. Compared to vehicle‐treated controls, rats treated with RU28362 and corticosterone had substantially blunted stress‐induced corticosterone and ACTH production, respectively. Furthermore, treatment with RU28362 significantly blunted stress‐induced CRH hnRNA expression in the PVN. By contrast, neither RU28362 nor corticosterone treatment had an effect on stress‐induced neuronal activation as measured by c‐fos mRNA and its protein product in the PVN. This dissociation between c‐fos and CRH gene expression suggests that glucocorticoid suppression of HPA activity within this time‐frame is not a result of decreased excitatory neural input to the PVN, but instead depends on some direct effect of RU28362 on cells intrinsic to the HPA axis.
Journal of Neuroendocrinology – Wiley
Published: Nov 1, 2003
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