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Cooling effects on nitric oxide production by rabbit ear and femoral arteries during cholinergic stimulation

Cooling effects on nitric oxide production by rabbit ear and femoral arteries during cholinergic... 1 Ear (cutaneous) and femoral (deep) arteries from rabbit were perfused at 37°C and 24°C (cooling) and the production of nitrite, as an index of nitric oxide production, was measured under basal conditions and cholinergic stimulation. 2 In both types of arteries under control conditions, the basal production of nitrite was similar at 24°C and 37°C. Compared with the control conditions, the basal production of nitrite was significantly lower in ear and femoral arteries without endothelium or treated with NG‐nitro‐L‐arginine methyl ester (L‐NAME, 10−4m) but it was similar in those treated with atropine (10−6m). 3 At 37°C, methacholine (10−7‐10−5 m) increased the production of nitrite in ear and femoral arteries; this increase persisted during 30–60 min and was practically abolished by L‐NAME (10−4m), atropine (10−6m), or removal of the endothelium. In ear arteries the total nitrite production to activation with methacholine was higher at 24°C than at 37°C due to this production persisted increased for a longer period (> 150 min), whereas in femoral arteries it was lower at 24°C than at 37°C. 4 It is suggested that: (a) the endothelium of rabbit ear and femoral arteries produce nitric oxide under basal conditions, which is increased by cholinergic stimulation, and (b) cooling potentiates endothelial nitric oxide production to cholinergic stimulation in cutaneous arteries, whereas it inhibits this production in deep arteries. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Pharmacology Wiley

Cooling effects on nitric oxide production by rabbit ear and femoral arteries during cholinergic stimulation

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References (24)

Publisher
Wiley
Copyright
1994 British Pharmacological Society
ISSN
0007-1188
eISSN
1476-5381
DOI
10.1111/j.1476-5381.1994.tb17024.x
Publisher site
See Article on Publisher Site

Abstract

1 Ear (cutaneous) and femoral (deep) arteries from rabbit were perfused at 37°C and 24°C (cooling) and the production of nitrite, as an index of nitric oxide production, was measured under basal conditions and cholinergic stimulation. 2 In both types of arteries under control conditions, the basal production of nitrite was similar at 24°C and 37°C. Compared with the control conditions, the basal production of nitrite was significantly lower in ear and femoral arteries without endothelium or treated with NG‐nitro‐L‐arginine methyl ester (L‐NAME, 10−4m) but it was similar in those treated with atropine (10−6m). 3 At 37°C, methacholine (10−7‐10−5 m) increased the production of nitrite in ear and femoral arteries; this increase persisted during 30–60 min and was practically abolished by L‐NAME (10−4m), atropine (10−6m), or removal of the endothelium. In ear arteries the total nitrite production to activation with methacholine was higher at 24°C than at 37°C due to this production persisted increased for a longer period (> 150 min), whereas in femoral arteries it was lower at 24°C than at 37°C. 4 It is suggested that: (a) the endothelium of rabbit ear and femoral arteries produce nitric oxide under basal conditions, which is increased by cholinergic stimulation, and (b) cooling potentiates endothelial nitric oxide production to cholinergic stimulation in cutaneous arteries, whereas it inhibits this production in deep arteries.

Journal

British Journal of Pharmacology – Wiley

Published: Oct 1, 1994

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