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- Publisher
- Wiley
- Copyright
- © Federation of American Societies for Experimental Biology
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- DOI
- 10.1096/fasebj.2.10.2838362
- Publisher site
- See Article on Publisher Site
Abstract
Guanine nudeotide‐binding regulatory proteins similar to Gs and Gi may be involved in the activation of phospholipases C and A2 by hormones and other ligands. The binding of hormones to receptors that activate phospholipase C is decreased by guanine nucleotides and these hormones also stimulate a high‐affinity GTPase activity in cell membranes. Effects of hormones on phospholipase C activity in cell‐free preparations are dependent on the presence of guanine nucleotides. In addition, fluoride and nonhydrolyzable GTP analogs activate phospholipases in a manner that can be blocked by GDPβS. The putative guanine nucleotide‐binding regulatory protein that appears to be involved in activation of phospholipase C is sensitive to pertussis toxin in some cells but not in others.— Fain, J. N.; Wallace, M. A.; Wojcikiewigz, R. J. H. Evidence for involvement of guanine nucleotide‐binding regulatory proteins in the activation of phospholipases by hormones. FASEB J, 2: 2569‐2574; 1988.
Journal
The FASEB journal – Wiley
Published: Jul 1, 1988
Keywords: ; ; ; ; ; ;