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- Publisher
- Annual Reviews
- Copyright
- Copyright © 1997 by Annual Reviews Inc. All rights reserved
- Subject
- Review Articles
- ISSN
- 0147-006X
- eISSN
- 1545-4126
- DOI
- 10.1146/annurev.neuro.20.1.483
- pmid
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Abstract
▪ Abstract Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster , and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.
Journal
Annual Review of Neuroscience – Annual Reviews
Published: Mar 1, 1997