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- Publisher
- Springer Journals
- Copyright
- Copyright © 2009 by Springer-Verlag
- Subject
- Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
- ISSN
- 0304-8608
- eISSN
- 1432-8798
- DOI
- 10.1007/s00705-009-0503-9
- pmid
- 19774337
- Publisher site
- See Article on Publisher Site
Abstract
The antiviral activity of total alkaloids from Commelina communis L. (TAC) against influenza virus A/PR/8/34 (H1N1) was investigated in vitro and in vivo. TAC exhibited an inhibitory action on the growth of influenza virus in Madin-Darby canine kidney cells when added before or after viral infection. In mice infected with influenza virus, orally administered TAC at 8, 16 or 32 mg/kg per day for 6 days significantly increased the survival rate, prolonged the mean survival time and reduced the viral titers in the lung and the lung index, compared with that of the untreated virus control. The results obtained suggest that TAC has a pronounced protective effect against infection by influenza A virus.
Journal
Archives of Virology – Springer Journals
Published: Nov 1, 2009