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HLA‐E polymorphism in patients with recurrent spontaneous abortion

HLA‐E polymorphism in patients with recurrent spontaneous abortion Abstract: The aim of this study was to compare the frequencies of five HLA‐E alleles in 82 women with recurrent spontaneous abortions with that of 150 random Danish controls. PCR sequence‐specific oligonucleotide typing was carried out to detect polymorphism in exons 2 and 3 of the HLA‐E gene. In informative samples sequencing of these two exons was also undertaken to confirm the presence of the HLA‐E*01031 allele. HLA‐E*0101, HLA‐ E*01032 and HLA‐E*01031 were detected with frequencies of 56.7%, 33.6% and 9.6% in controls and 58,5%, 32.9% and 8.5% in patients with recurrent abortion, respectively. No HLA‐E*0102 and E*0104 alleles could be detected. Since the HLA‐E allele distribution was similar in women with recurrent spontaneous abortion and controls, it is suggested that maternal HLA‐E polymorphism per se does not play any role in the pathogenesis of this disorder of pregnancy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Tissue Antigens Wiley

HLA‐E polymorphism in patients with recurrent spontaneous abortion

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References (26)

Publisher
Wiley
Copyright
Copyright © 1998 Munksgaard
ISSN
0001-2815
eISSN
1399-0039
DOI
10.1111/j.1399-0039.1998.tb03088.x
Publisher site
See Article on Publisher Site

Abstract

Abstract: The aim of this study was to compare the frequencies of five HLA‐E alleles in 82 women with recurrent spontaneous abortions with that of 150 random Danish controls. PCR sequence‐specific oligonucleotide typing was carried out to detect polymorphism in exons 2 and 3 of the HLA‐E gene. In informative samples sequencing of these two exons was also undertaken to confirm the presence of the HLA‐E*01031 allele. HLA‐E*0101, HLA‐ E*01032 and HLA‐E*01031 were detected with frequencies of 56.7%, 33.6% and 9.6% in controls and 58,5%, 32.9% and 8.5% in patients with recurrent abortion, respectively. No HLA‐E*0102 and E*0104 alleles could be detected. Since the HLA‐E allele distribution was similar in women with recurrent spontaneous abortion and controls, it is suggested that maternal HLA‐E polymorphism per se does not play any role in the pathogenesis of this disorder of pregnancy.

Journal

Tissue AntigensWiley

Published: Dec 1, 1998

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