Access the full text.
Sign up today, get DeepDyve free for 14 days.
Metabolism ofepox - idized phosphatidylcholine by PLA 2 and epoxide hydrolase
J. Strosznajder, A. Radomiñska-pyrek, J. Lazarewicz, L. Horrocks (1977)
Synthesis in vitro of 1-alkyl-2-acyl- and 1,2-diacyl-sn-glycerophosphorylcholines and ethanolamines by neuronal, glial and synaptosomal fractions from adult rabbit brain.Bulletin de l'Academie polonaise des sciences. Serie des sciences biologiques, 25 6
(1979)
PGFz,, thromboxane B2 and HETE levels in gerbil brain after ligation of common carotid arteries and decapitation
M. Aveldaño, N. Bazan (1975)
Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemiaJournal of Neurochemistry, 25
Baker Baker, Thompson Thompson (1973)
Selective acylation of 1‐acylglycerophosphorylinositol by rat brain microsomesJ. Biol. Chem., 248
J. Strosznajder, A. Radomiñska-pyrek, L. Horrocks (1979)
Choline and ethanolamine glycerophospholipid synthesis in isolated synaptosomes of rat brain.Biochimica et biophysica acta, 574 1
F. Kuijk, A. Sevanian, G. Handelman, E. Dratz (1987)
A new role for phospholipase A2: protection of membranes from lipid peroxidation damageTrends in Biochemical Sciences, 12
L. Foudin, J. Strosznajder, G. Sun (1983)
Effects of Ischemia and Severe Hypoxia on Arachidonic Acid Uptake by Rat Brain MembranesNeurochemical Pathology, 1
M. Murphy, M. Spence (1982)
Acid:Coenzyme A Ligase in Brain: Fatty Acid Specificity in Cellular and Subcellular FractionsJournal of Neurochemistry, 38
S. Yoshida, R. Busto, M. Santiso, M. Ginsberg (1984)
Brain Lipid Peroxidation Induced by Postischemic Reoxygenation in vitro: Effect of Vitamin EJournal of Cerebral Blood Flow & Metabolism, 4
D. Gamache, A. Fawzy, R. Franson (1988)
Preferential hydrolysis of peroxidized phospholipid by lysosomal phospholipase C.Biochimica et biophysica acta, 958 1
Booth Booth, Clark Clark (1978)
A rapid method for the preparation of relatively pure, metabolically competent synaptosomes BiochemJ., 176
Pediconi Pediconi, Turco Turco, Bazan Bazan (1983)
Effects of postdecapitation ischemia on the metabolism of ( 14 C)arachidonic acid and ( 14 C)palmitic acid in the mouse brainNeurochem. Res., 8
J. Beckman, S. Borowitz, I. Burr (1987)
The role of phospholipase A activity in rat liver microsomal lipid peroxidation.The Journal of biological chemistry, 262 4
R. Baker, W. Thompson (1973)
Selective acylation of 1-acylglycerophosphorylinositol by rat brain microsomes. Comparison with 1-acylglycerophosphorylcholine.The Journal of biological chemistry, 248 20
N. Bazan, E. Turco (1980)
Membrane lipids in the pathogenesis of brain edema: phospholipids and arachidonic acid, the earliest membrane components changed at the onset of ischemia.Advances in neurology, 28
E. Wei, R. Lamb, H. Kontos (1982)
Increased phospholipase C activity after experimental brain injury.Journal of neurosurgery, 56 5
A. Gornall, C. Bardawill, M. David (1949)
Determination of serum proteins by means of the biuret reaction.The Journal of biological chemistry, 177 2
Nicolas Bazan (1970)
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain.Biochimica et biophysica acta, 218 1
J. Marion, L. Wolfe (1979)
Origin of the arachidonic acid released post-mortem in rat forebrain.Biochimica et biophysica acta, 574 1
G. Sun, K. Su (1979)
METABOLISM OF ARACHIDONOYL PHOSPHOGLYCERIDES IN MOUSE BRAIN SUBCELLULAR FRACTIONSJournal of Neurochemistry, 32
Abe Abe, Kogure Kogure, Yamamoto Yamamoto, Imazawa Imazawa, Miyamoto Miyamoto (1987)
Mechanism of arachidonic acid liberation during ischemia in gerbil cortexJ. Neurochem., 48
D. Birkle, N. Bazan (1984)
Lipoxygenase- and cyclooxygenase-reaction products and incorporation into glycerolipids or radiolabeled arachidonic acid in the bovine retina.Prostaglandins, 27 2
C. Spagnuolo, A. Petroni, M. Blasevich, C. Galli (1979)
Differential effects of probenecid on the levels of endogenous PGF2α and TXB2 in brain cortexProstaglandins, 18
(1983)
Identification of 5-hydroxyeicosatetraenoic
Strosznajder Strosznajder, Sun Sun (1981)
Effects of acute hypoxia on incorporation of (1‐ 14 C)arachidonic acid into glycerolipids of rat brainNeurochem. Res., 6
B. Watson, R. Busto, W. Goldberg, M. Santiso, S. Yoshida, M. Ginsberg (1984)
Lipid Peroxidation In Vivo Induced by Reversible Global Ischemia in Rat BrainJournal of Neurochemistry, 42
S. Yoshida, S. Inoh, T. Asano, Keiji Sano, M. Kubota, H. Shimazaki, N. Ueta (1980)
Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain. Lipid peroxidation as a possible cause of postischemic injury.Journal of neurosurgery, 53 3
S. Yoshida, S. Harik, R. Busto, M. Santiso, E. Martinez, M. Ginsberg (1984)
Free Fatty Acids and Energy Metabolites in Ischemic Cerebral Cortex with Noradrenaline DepletionJournal of Neurochemistry, 42
M. Zaleska, D. Wilson (1987)
A Sensitive and Selective Method for Quantitative Analysis of Products of Lipid Peroxidation
B. Siesjö (1981)
Cell Damage in the Brain: A Speculative SynthesisJournal of Cerebral Blood Flow & Metabolism, 1
P. Chan, R. Fishman (1978)
Brain edema: induction in cortical slices by polyunsaturated fatty acids.Science, 201 4353
(1981)
Effects of acute hypoxia on incorporation
R. Gaudet, Lawrence Levine (1979)
Transient cerebral ischemia and brain prostaglandins.Biochemical and biophysical research communications, 86 3
Sun Sun, Manning Manning, Strosznajder Strosznajder (1980)
Effects of postdecapitative ischemia and hypoxia on the phosphoglyceride acyl groups of rat brain membranesNeurochem. Res., 5
S. Adesuyi, C. Cockrell, D. Gamache, E. Ellis (1985)
Lipoxygenase Metabolism of Arachidonic Acid in BrainJournal of Neurochemistry, 45
M. Moskowitz, K. Kiwak, K. Hekimian, L. Levine (1984)
Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion.Science, 224 4651
K. Abe, K. Kogure, Hirotaka Yamamoto, M. Imazawa, Kenji Miyamoto (1987)
Mechanism of Arachidonic Acid Liberation During Ischemia in Gerbil Cerebral CortexJournal of Neurochemistry, 48
D. Corbin, G. Sun (1978)
CHARACTERIZATION OF THE ENZYMIC TRANSFER OF ARACHIDONOYL GROUPS TO 1‐ACYL‐PHOSPHOGLYCERIDES IN MOUSE SYNAPTOSOME FRACTIONJournal of Neurochemistry, 30
N. Suzuki, Tetsuya Nakamura, Sukehiro Imabayashi, Yoko Ishikawa, T. Sasaki, T. Asano (1983)
Identification of 5‐Hydroxy Eicosatetraenoic Acid in Cerebrospinal Fluid After Subarachnoid HemorrhageJournal of Neurochemistry, 41
(1985)
Metabolism and function of fatty acids in brain
(1978)
A rapid method for the DreDaration of relatively pure, metabolically competent synaptosomes
Strosznajder Strosznajder, Radominska‐Pyrek Radominska‐Pyrek, Lazarewicz Lazarewicz, Horrocks Horrocks (1977)
Synthesis in vitro of 1‐alkyl‐2‐acyl and 1,2‐diacyl‐ sn ‐glycero‐3‐phosphorylcholines and ethanolamines by neuronal, glial and synaptosomal fractions from adult rabbit brainBull. Pol. Acad. Sci. Ser. Sci. Biol., 25
S. Yoshida, K. Abe, R. Busto, B. Watson, K. Kogure, M. Ginsberg (1982)
Influence of transient ischemia on lipid-soluble antioxidants, free fatty acids and energy metabolites in rat brainBrain Research, 245
A. Edgar, J. Strosznajder, L. Horrocks (1982)
Activation of Ethanolamine Phospholipase A2 in Brain During IschemiaJournal of Neurochemistry, 39
Sun Sun, Su Su, Der Der, Tang Tang (1979)
Enzymic regulation of arachidonate metabolism in membrane phosphoglyceridesLipids, 14
M. Murphy, M. Spenge (1977)
EFFECT OF FATTY‐ACID DOUBLE‐BOND POSITION ON THE SELECTIVITY OF RAT‐BRAIN ENZYMES: THE INCORPORATION OF OLEIC AND CIS‐VACCENIC ACIDS INTO LYSOLECITHIN IN VITROJournal of Neurochemistry, 29
T. Walden, H. Hughes (1987)
Prostaglandin and Lipid Metabolism in Radiation Injury
Yoshida Yoshida, Busto Busto, Santiso Santiso, Ginsberg Ginsberg (1984a)
Brain lipid peroxidation induced by postischemic reoxygenation in vitro: effect of vitamin EJ. Cereb. Blood Flow Melab., 4
Abstract: The unsaturated fatty acids that rapidly accumulate during ischemia are thought to participate in inducing irreversible brain injury, especially because they are highly susceptible to peroxidation when the tissue is reoxygenated. Our hypothesis was that peroxidation products of unsaturated fatty acids interfere with the reacylation of synaptic phospholipids, a process essential to membrane repair. To test this hypothesis, we have examined the effect of fatty acid hydroperoxides on incorporation of (1‐14C)arachidonic acid into synapto‐somal phospholipids. Rat forebrain synaptosomes were incubated with arachidonic or linoleic acid hydroperoxides and (14C)arachidonate, and then lipids were extracted and separated by TLC. Both hydroperoxides inhibited (14C)arachidonate incorporation into phospholipids in a concentration‐dependent manner, with 50% inhibition occurring at less than 25 μM hydroperoxide, in both the absence and presence of exogenous lysophospholipids. The inhibition was of the non‐competitive type. It is concluded that (a) low levels of fatty acid hydroperoxides inhibit the reacylation of synaptosomal phospholipids, and (b) this inhibition may constitute an important mechanism whereby peroxidative processes contribute to irreversible brain damage.
Journal of Neurochemistry – Wiley
Published: Jan 1, 1989
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.