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The Relationship of Basal Cell Carcinomas and Squamous Cell Carcinomas to Solar Keratoses

The Relationship of Basal Cell Carcinomas and Squamous Cell Carcinomas to Solar Keratoses Abstract • Six thousand four hundred sixteen people aged 40 years and over from three different locations in Victoria (Australia) were examined on the hands, forearms, head, and neck for the presence of solar keratoses and basal (BCCs) and squamous cell carcinomas (SCCs). Analysis of the relationship between these tumors revealed that the factors which predicted the likelihood of developing a solar keratosis were essentially the same as those that predicted the likelihood of developing a BCC and/or an SCC. These were age, sex, years of residence in Australia, indoor or outdoor occupation, tanning ability, propensity to sunburn, and location of residence. The presence of a coexisting solar keratosis was necessary for the development of an SCC in contrast to the development of a BCC. The findings suggest that unlike BCCs, the majority of SCCs in light-exposed areas may arise from preexisting solar keratoses. Whereas the prevalence of BCCs and SCCs was relatively constant in the three locations, the prevalence of solar keratoses differed markedly in direct relation to the degree of insolation. This suggests that solar keratoses are a more sensitive indicator of sunlight exposure than invasive carcinoma. (Arch Dermatol 1988;124:1039-1042) References 1. Marks R, Ponsford MW, Selwood TS, et al: Non-melanotic skin cancer and solar keratoses in Victoria . Med J Aust 1983;2:618-622. 2. Epstein JH: Photocarcinogenesis, skin cancer, and aging . J Am Acad Dermatol 1983;9:487-503.Crossref 3. Goodman G, Marks R, Selwood TS, et al: Non-melanotic skin cancer and solar keratoses in Victoria: II. Clinical studies . Aust J Dermatol 1984;25:103-106.Crossref 4. Ponsford MW, Goodman G, Marks R: The prevalence and accuracy of diagnosis of non-melanotic skin cancer in Victoria . Aust J Dermatol 1983;24:79-82.Crossref 5. Engelman L: Stepwise logistic regression , in Dixon WJ (ed): BMDP Statistical Software. Berkeley , University of California Press, 1981, pp 330-344. 6. Marks R, Selwood TS: Solar keratoses: The association with erythemal ultraviolet radiation in Australia . Cancer 1985;56:2332-2336.Crossref 7. Sanderson KV, Mackie R: Tumors of the skin , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology , ed 3. Boston, Blackwell Scientific Publications Inc, 1979, pp 2179-2182. 8. Marks R, Foley P, Goodman G, et al: Spontaneous remission of solar keratoses: The case for conservative management . Br J Dermatol 1986;115:649-655.Crossref 9. Lung cancer mortality and pre-malignant changes in bronchial epithelium , in The Health Consequences of Smoking: Cancer: A Report of the Surgeon General , US Dept of Health and Human Services, 1982, pp 55-59. 10. Campion MJ, McCance DJ, Cuzick J, et al: Progressive potential of mild cervical atypia: Prospective cytological, colposcopic, and virological study . Lancet 1986;2:237-240.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

The Relationship of Basal Cell Carcinomas and Squamous Cell Carcinomas to Solar Keratoses

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1988.01670070027013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Six thousand four hundred sixteen people aged 40 years and over from three different locations in Victoria (Australia) were examined on the hands, forearms, head, and neck for the presence of solar keratoses and basal (BCCs) and squamous cell carcinomas (SCCs). Analysis of the relationship between these tumors revealed that the factors which predicted the likelihood of developing a solar keratosis were essentially the same as those that predicted the likelihood of developing a BCC and/or an SCC. These were age, sex, years of residence in Australia, indoor or outdoor occupation, tanning ability, propensity to sunburn, and location of residence. The presence of a coexisting solar keratosis was necessary for the development of an SCC in contrast to the development of a BCC. The findings suggest that unlike BCCs, the majority of SCCs in light-exposed areas may arise from preexisting solar keratoses. Whereas the prevalence of BCCs and SCCs was relatively constant in the three locations, the prevalence of solar keratoses differed markedly in direct relation to the degree of insolation. This suggests that solar keratoses are a more sensitive indicator of sunlight exposure than invasive carcinoma. (Arch Dermatol 1988;124:1039-1042) References 1. Marks R, Ponsford MW, Selwood TS, et al: Non-melanotic skin cancer and solar keratoses in Victoria . Med J Aust 1983;2:618-622. 2. Epstein JH: Photocarcinogenesis, skin cancer, and aging . J Am Acad Dermatol 1983;9:487-503.Crossref 3. Goodman G, Marks R, Selwood TS, et al: Non-melanotic skin cancer and solar keratoses in Victoria: II. Clinical studies . Aust J Dermatol 1984;25:103-106.Crossref 4. Ponsford MW, Goodman G, Marks R: The prevalence and accuracy of diagnosis of non-melanotic skin cancer in Victoria . Aust J Dermatol 1983;24:79-82.Crossref 5. Engelman L: Stepwise logistic regression , in Dixon WJ (ed): BMDP Statistical Software. Berkeley , University of California Press, 1981, pp 330-344. 6. Marks R, Selwood TS: Solar keratoses: The association with erythemal ultraviolet radiation in Australia . Cancer 1985;56:2332-2336.Crossref 7. Sanderson KV, Mackie R: Tumors of the skin , in Rook A, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology , ed 3. Boston, Blackwell Scientific Publications Inc, 1979, pp 2179-2182. 8. Marks R, Foley P, Goodman G, et al: Spontaneous remission of solar keratoses: The case for conservative management . Br J Dermatol 1986;115:649-655.Crossref 9. Lung cancer mortality and pre-malignant changes in bronchial epithelium , in The Health Consequences of Smoking: Cancer: A Report of the Surgeon General , US Dept of Health and Human Services, 1982, pp 55-59. 10. Campion MJ, McCance DJ, Cuzick J, et al: Progressive potential of mild cervical atypia: Prospective cytological, colposcopic, and virological study . Lancet 1986;2:237-240.Crossref

Journal

Archives of Dermatology – American Medical Association

Published: Jul 1, 1988

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