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Helper or cytotoxic T cells often react preferentially against antigen associated with syngeneic rather than allogeneic target cells or lymphocytes. Various explanations have been offered fot this restriction (see below); one was put forward recently by Makela and colleagues in this Journal (21). The purpose of the present note is to outline a simple explanation of these phenomena, one which involves no radical assumptions and is consistent with reports that helper and cytotoxic cells can react with antigen associated with allogeneic cells (1, 5, 6, 27). Phenomena There are three groups of phenomena that may have the same basis. 1. Cell-cell cooperation does not occur efficiently between T and B cells of different histocompatibility types (15, 16), 2. Optimal killing of antigen-associated target cells by T cells sensitized to the antigen requires major histocompatibility complex (MHC)-region identity between killer and target. This has been shown with virus-infected target cells (28), with cells to which hapten has been coupled (24), and with cytotoxic T cells reactive against minor histocompatibility or Y antigens (2, 12). 3. There is very recent evidence that T helper cells can be allotype-specific; that is, T cells from mice producing Ig-1 of allotype 'a' may
Scandinavian Journal of Immunology – Wiley
Published: Jan 1, 1977
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