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Collapse and repair of replication forks in Escherichia coli

Collapse and repair of replication forks in Escherichia coli Summary Single‐strand interruptions in a template DNA are likely to cause collapse of replication forks. We propose a model for the repair of collapsed replication forks in Escherichia coli by the RecBCD recombinational pathway. The model gives reasons for the preferential orientation of Chi sites in the E. coli chromosome and accounts for the hyper‐rec phenotype of the strains with increased numbers of single‐strand interruptions in their DNA. On the basis of the model we offer schemes for various repeat‐mediated recombinational events and discuss a mechanism for quasi‐conservative DNA replication explaining the recombinational repair‐associated mutagenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Microbiology Wiley

Collapse and repair of replication forks in Escherichia coli

Molecular Microbiology , Volume 16 (3) – May 1, 1995

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References (98)

Publisher
Wiley
Copyright
Copyright © 1995 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0950-382X
eISSN
1365-2958
DOI
10.1111/j.1365-2958.1995.tb02403.x
Publisher site
See Article on Publisher Site

Abstract

Summary Single‐strand interruptions in a template DNA are likely to cause collapse of replication forks. We propose a model for the repair of collapsed replication forks in Escherichia coli by the RecBCD recombinational pathway. The model gives reasons for the preferential orientation of Chi sites in the E. coli chromosome and accounts for the hyper‐rec phenotype of the strains with increased numbers of single‐strand interruptions in their DNA. On the basis of the model we offer schemes for various repeat‐mediated recombinational events and discuss a mechanism for quasi‐conservative DNA replication explaining the recombinational repair‐associated mutagenesis.

Journal

Molecular MicrobiologyWiley

Published: May 1, 1995

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