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213 97 97 2 2 J. C. Neill S. J. Cooper School of Psychology University of Birmingham B15 2TT Birmingham UK Abstract The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d -fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d -Fenfluramine's effect was attenuated by the mixed 5-HT 1 /5-HT 2 receptor antagonists, methiothepin and metergoline; by the 5-HT 2 receptor antagonist ritanserin; and by (±)cyanopindolol, a mixed 5-HT 1A /5-HT 1B receptor antagonist. In contrast, d -fenfluramine's effect was not antagonised by the 5-HT 2 receptor antagonists ketanserin and ICI 169 369; the 5-HT 3 receptor antagonist ICS 205 930; or by xylamidine, a peripheral 5-HT receptor antagonist. In this feeding model, none of the 5-HT antagonists, when tested alone, had any effect to increase palatable food consumption. The pattern of results obtained strongly suggest that central 5-HT 1 receptors play an important role in the mediation of d -fenfluramine-induced anorexia.
Psychopharmacology – Springer Journals
Published: Feb 1, 1989
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