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Evidence that d -fenfluramine anorexia is mediated by 5-HT 1 receptors

Evidence that d -fenfluramine anorexia is mediated by 5-HT 1 receptors 213 97 97 2 2 J. C. Neill S. J. Cooper School of Psychology University of Birmingham B15 2TT Birmingham UK Abstract The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d -fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d -Fenfluramine's effect was attenuated by the mixed 5-HT 1 /5-HT 2 receptor antagonists, methiothepin and metergoline; by the 5-HT 2 receptor antagonist ritanserin; and by (±)cyanopindolol, a mixed 5-HT 1A /5-HT 1B receptor antagonist. In contrast, d -fenfluramine's effect was not antagonised by the 5-HT 2 receptor antagonists ketanserin and ICI 169 369; the 5-HT 3 receptor antagonist ICS 205 930; or by xylamidine, a peripheral 5-HT receptor antagonist. In this feeding model, none of the 5-HT antagonists, when tested alone, had any effect to increase palatable food consumption. The pattern of results obtained strongly suggest that central 5-HT 1 receptors play an important role in the mediation of d -fenfluramine-induced anorexia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Evidence that d -fenfluramine anorexia is mediated by 5-HT 1 receptors

Psychopharmacology , Volume 97 (2) – Feb 1, 1989

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References (37)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00442252
Publisher site
See Article on Publisher Site

Abstract

213 97 97 2 2 J. C. Neill S. J. Cooper School of Psychology University of Birmingham B15 2TT Birmingham UK Abstract The effects of eight serotonin (5-HT) receptor antagonists on the anorectic effect of d -fenfluramine (3.0 mg/kg, IP) were examined in a test of sweet mash consumption, using non-deprived male rats. d -Fenfluramine's effect was attenuated by the mixed 5-HT 1 /5-HT 2 receptor antagonists, methiothepin and metergoline; by the 5-HT 2 receptor antagonist ritanserin; and by (±)cyanopindolol, a mixed 5-HT 1A /5-HT 1B receptor antagonist. In contrast, d -fenfluramine's effect was not antagonised by the 5-HT 2 receptor antagonists ketanserin and ICI 169 369; the 5-HT 3 receptor antagonist ICS 205 930; or by xylamidine, a peripheral 5-HT receptor antagonist. In this feeding model, none of the 5-HT antagonists, when tested alone, had any effect to increase palatable food consumption. The pattern of results obtained strongly suggest that central 5-HT 1 receptors play an important role in the mediation of d -fenfluramine-induced anorexia.

Journal

PsychopharmacologySpringer Journals

Published: Feb 1, 1989

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