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E. Appenrodt, R. Schnabel, Helmut Schwarzberg (1998)
Vasopressin administration modulates anxiety-related behavior in ratsPhysiology & Behavior, 64
S. File, N. Andrews, M. al-Farhan (1993)
Anxiogenic responses of rats on withdrawal from chronic ethanol treatment: effects of tianeptine.Alcohol and alcoholism, 28 3
S. File, R. Lister (1983)
Interactions of ethyl-β-carboline-3-carboxylate and Ro 15-1788 with CGS 8216 in an animal model of anxietyNeuroscience Letters, 39
E. Lephart, Joseph Thompson, K. Setchell, H. Adlercreutz, K. Weber (2000)
Phytoestrogens decrease brain calcium-binding proteins but do not alter hypothalamic androgen metabolizing enzymes in adult male ratsBrain Research, 859
K. Kawashima, T. Inoue, N. Tsutsumi, H. Endo (1996)
Effect of KCA-098 on the function of osteoblast-like cells and the formation of TRAP-positive multinucleated cells in a mouse bone marrow cell population.Biochemical pharmacology, 51 2
M. Brimble, R. Balment, C. Smith, R. Windle, M. Forsling (1991)
Influence of oxytocin on sodium excretion in the anaesthetized Brattleboro rat.The Journal of endocrinology, 129 1
S. File, P. Kenny, A. Ouagazzal (1998)
Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus.Behavioral neuroscience, 112 6
S. File, J. Hyde (1978)
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?British Journal of Pharmacology, 62
T. Lund, T. West, Lilyan Tian, Lihong Bu, D. Simmons, K. Setchell, H. Adlercreutz, E. Lephart (2001)
Visual spatial memory is enhanced in female rats (but inhibited in males) by dietary soy phytoestrogensBMC Neuroscience, 2
T. Sajdyk, D. Schober, D. Gehlert, A. Shekhar (1999)
Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responsesBehavioural Brain Research, 100
S. File, P. Seth (2003)
A review of 25 years of the social interaction test.European journal of pharmacology, 463 1-3
D. Haas, S. George (1988)
Single or repeated mild stress increases synthesis and release of hypothalamic corticotropin-releasing factorBrain Research, 461
Y. Kao, Changbao Zhou, M. Sherman, C. Laughton, Shiuan Chen (1998)
Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.Environmental Health Perspectives, 106
Holly Boettger-Tong, Lata Murthy, C. Chiappetta, John Kirkland, Bradford Goodwin, Herman Adlercreutz, G. Stancel, Sari Mäkelä (1986)
Accumulation of basement membrane components in interface between gastric carcinoma cells and fibroblasts in vitro.British Journal of Cancer, 54
S. File, S. Pellow, C. Braestrup (1985)
Effects of the β-carboline, FG 7142, in the social interaction test of anxiety and the holeboard: Correlations between behaviour and plasma concentrationsPharmacology Biochemistry and Behavior, 22
H. Kelestimur, R. Leach, J. Ward, M. Forsling (1997)
Vasopressin and oxytocin release during prolonged environmental hypoxia in the rat.Thorax, 52
S. File (1994)
Chronic exposure to noise modifies the anxiogenic response, but not the hypoactivity, detected on withdrawal from chronic ethanol treatmentPsychopharmacology, 116
M. Forsling, P. Strömberg, M. Åkerlund (1982)
Effect of ovarian steroids on vasopressin secretion.The Journal of endocrinology, 95 1
S. Boer, J. Slangen, J. Gugten (1991)
Effects of buspirone and chlordiazepoxide on plasma catecholamine and corticosterone levels in stressed and nonstressed ratsPharmacology Biochemistry and Behavior, 38
A. Dunn, S. File (1987)
Corticotropin-releasing factor has an anxiogenic action in the social interaction testHormones and Behavior, 21
Printed in U.S.A. Copyright © 1997 by The Endocrine Society Central Oxytocin Administration Reduces Stress- Induced Corticosterone Release and Anxiety Behavior in Rats*
S. File, N. Andrews (2005)
Low but not high doses of buspirone reduce the anxiogenic effects of diazepam withdrawalPsychopharmacology, 105
K. Weber, Kenneth Setchell, E. Lephart (2001)
Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens.Brain research. Developmental brain research, 126 2
S. File, Lynette Peet (1980)
The sensitivity of the rat corticosterone response to environmental manipulations and to chronic chlordiazepoxide treatmentPhysiology & Behavior, 25
P. Whitten, H. Patisaul, L. Young (2002)
Neurobehavioral actions of coumestrol and related isoflavonoids in rodents.Neurotoxicology and teratology, 24 1
M. Forsling, K. Peysner (1988)
Pituitary and plasma vasopressin concentrations and fluid balance throughout the oestrous cycle of the rat.The Journal of endocrinology, 117 3
G. Kuiper, J. Lemmen, B. Carlsson, J. Corton, S. Safe, P. Saag, B. Burg, J. Gustafsson (1998)
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β.Endocrinology, 139 10
N. Andrews, S. File (1993)
Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety.European journal of pharmacology, 235 1
Yuanlong Pan, M. Anthony, Sheree Watson, T. Clarkson (2000)
Soy Phytoestrogens Improve Radial Arm Maze Performance in Ovariectomized Retired Breeder Rats and Do Not Attenuate Benefits of 17&bgr;‐Estradiol TreatmentMenopause, 7
N. Brown, K. Setchell (2001)
Animal Models Impacted by Phytoestrogens in Commercial Chow: Implications for Pathways Influenced by HormonesLaboratory Investigation, 81
S. File, S. Vellucci, Sabine Wendlandt (1979)
Corticosterone ‐ an anxiogenic or an anxiolytic agent?Journal of Pharmacy and Pharmacology, 31
H. Baldwin, S. File (2004)
Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxietyPsychopharmacology, 97
S. Mäkelä, M. Poutanen, J. Lehtimäki, M. Kostian, R. Santti, R. Vihko (1995)
Estrogen-Specific 17β-Hydroxysteroid Oxidoreductase Type 1 (E.C. 1.1.1.62) as a Possible Target for the Action of PhytoestrogensProceedings of the Society for Experimental Biology and Medicine, 208
Carney Ja, Walker Bl (1973)
Mode of killing and plasma corticosterone concentrations in the rat.Laboratory Animal Science, 23
B. Costall, B. Jones, M. Kelly, R. Naylor, D. Tomkins (1989)
Exploration of mice in a black and white test box: Validation as a model of anxietyPharmacology Biochemistry and Behavior, 32
D. Peričić, N. Pivac (1996)
Effects of diazepam on conflict behaviour and on plasma corticosterone levels in male and female ratsNaunyn-Schmiedeberg's Archives of Pharmacology, 353
S. File, S. Pellow (1985)
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: Evidence for benzodiazepine withdrawal?Pharmacology Biochemistry and Behavior, 23
S. File, P. Mabbutt, JACQUELINE Walker (1988)
Comparison of Adaptive Responses in Familiar and Novel Environments: Modulatory FactorsAnnals of the New York Academy of Sciences, 525
File Se (1984)
The validation of animal tests of anxiety--pharmacological implications.Polish journal of pharmacology and pharmacy, 36
C. Wotjak, M. Kubota, G. Liebsch, A. Montkowski, F. Holsboer, I. Neumann, R. Landgraf (1996)
Release of Vasopressin within the Rat Paraventricular Nucleus in Response to Emotional Stress: A Novel Mechanism of Regulating Adrenocorticotropic Hormone Secretion?The Journal of Neuroscience, 16
S. File, R. Lister, D. Nutt (1982)
The anxiogenic action of benzodiazepine antagonistsNeuropharmacology, 21
E. Lephart, T. West, K. Weber, R. Rhees, K. Setchell, H. Adlercreutz, T. Lund (2002)
Neurobehavioral effects of dietary soy phytoestrogens.Neurotoxicology and teratology, 24 1
A. Kampov-Polevoy, D. Matthews, L. Gause, A. Morrow, D. Overstreet (2000)
P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking.Alcoholism, clinical and experimental research, 24 3
E. Hrabovszky, I. Kalló, Tibor N, P. Shughrue, I. Merchenthaler, Zsolt Liposits (1998)
Expression of Estrogen Receptor-β Messenger Ribonucleic Acid in Oxytocin and Vasopressin Neurons of the Rat Supraoptic and Paraventricular Nuclei.Endocrinology, 139 5
D. Gibbs (1984)
Dissociation of oxytocin, vasopressin and corticotropin secretion during different types of stress.Life sciences, 35 5
S. Barlow, A. Knight, F. Sullivan (1979)
Plasma corticosterone responses to stress following chronic oral administration of diazepam in the ratJournal of Pharmacy and Pharmacology, 31
M. Cotroneo, Jun Wang, W. Fritz, I. Eltoum, C. Lamartiniere (2002)
Genistein action in the prepubertal mammary gland in a chemoprevention model.Carcinogenesis, 23 9
S. File, S. Pellow (1984)
The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxideBrain Research, 310
R. Rodgers, József Haller, Andrew Holmes, J. Halasz, T. Walton, Paul Brain (1999)
Corticosterone response to the plus-maze High correlation with risk assessment in rats and micePhysiology & Behavior, 68
S. File, A. Zharkovsky, P. Hitchcott (1992)
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawalProgress in Neuro-Psychopharmacology and Biological Psychiatry, 16
S. Boer, J. Gugten, J. Slangen (1990)
Brain benzodiazepine receptor-mediated effects on plasma catecholamine and corticosterone concentrations in ratsBrain Research Bulletin, 24
M. Harbuz, S. Lightman (1992)
Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation.The Journal of endocrinology, 134 3
K. Almstrup, Mariana Fernández, J. Petersen, N. Olea, N. Skakkebaek, H. Leffers (2002)
Dual effects of phytoestrogens result in u-shaped dose-response curves.Environmental Health Perspectives, 110
G. Hatton (1990)
Emerging concepts of structure-function dynamics in adult brain: The hypothalamo-neurohypophysial systemProgress in Neurobiology, 34
S. File (1988)
The Benzodiazepine Receptor and its Role in AnxietyBritish Journal of Psychiatry, 152
G. Degen, P. Janning, P. Diel, H. Bolt (2002)
Estrogenic isoflavones in rodent diets.Toxicology letters, 128 1-3
S. File, S. Vellucci (1978)
Studies on the role of ACTH and of 5‐HT in anxiety, using an animal modelJournal of Pharmacy and Pharmacology, 30
J. Dunn, L. Scheving (1971)
Plasma corticosterone levels in rats killed sequentially at the "trough" or "peak" of the adrenocortical cycle.The Journal of endocrinology, 49 2
G. Kuiper, P. Shughrue, I. Merchenthaler, J. Gustafsson (1998)
The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine SystemsFrontiers in Neuroendocrinology, 19
R. Lahti, C. Barsuhn (1974)
The effect of minor tranquilizers on stress-induced increases in rat plasma corticosteroidsPsychopharmacologia, 35
R. Santell, Y. Chang, M. Nair, W. Helferich (1997)
Biochemical and Molecular Roles of Nutrients Dietary Genistein Exerts Estrogenic Effects upon the Uterus , Mammary Gland and the Hypothalamic / Pituitary Axis in Rats 1
S. File, H. Baldwin, P. Hitchcott (2004)
Flumazenil but not nitrendipine reverses the increased anxiety during ethanol withdrawal in the ratPsychopharmacology, 98
S. Pellow, S. File (1986)
Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the ratPharmacology Biochemistry and Behavior, 24
G. Fur, F. Guilloux, N. Mitrani, J. Mizoule, A. Uzan (1979)
Relationships between plasma corticosteroids and benzodiazepines in stress.The Journal of pharmacology and experimental therapeutics, 211 2
J. Bail, F. Varnat, J. Nicolas, G. Habrioux (1998)
Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids.Cancer letters, 130 1-2
B. Costall, M. Kelly, E. Onaivi, R. Naylor (1990)
The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuseNaunyn-Schmiedeberg's Archives of Pharmacology, 341
S. Pellow, P. Chopin, S. File, M. Briley (1985)
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the ratJournal of Neuroscience Methods, 14
K. Peysner, M. Forsling (1990)
Effect of ovariectomy and treatment with ovarian steroids on vasopressin release and fluid balance in the rat.The Journal of endocrinology, 124 2
C. To, Z. Anheuer, Gyorgy Bagdy (1999)
Effects of acute and chronic fluoxetine treatment of CRH-induced anxiety.Neuroreport, 10 3
(2001)
Soy Isoflavone Supplements Antagonize Reproductive Behavior and Estrogen Receptor α- and β-Dependent Gene Expression in the Brain1
N. Laflamme, Rossella Nappi, G. Drolet, C. Labrie, S. Rivest (1998)
Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: anatomical evidence of distinct roles of each subtype.Journal of neurobiology, 36 3
File Se, N. Andrews (1993)
Benzodiazepine withdrawal: behavioural pharmacology and neurochemical changes.Biochemical Society symposium, 59
M. Spina, E. Merlo-Pich, Y. Akwa, C. Balducci, A. Basso, E. Zorrilla, K. Britton, J. Rivier, W. Vale, G. Koob (2002)
Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the ratPsychopharmacology, 160
C. Fernandes, M. Arnot, E. Irvine, A. Bateson, I. Martin, S. File (1999)
The effect of treatment regimen on the development of tolerance to the sedative and anxiolytic effects of diazepamPsychopharmacology, 145
S. File (1979)
Effects of ACTH4–10 in the social interaction test of anxietyBrain Research, 171
M. Piskuła, J. Yamakoshi, Yukihiko Iwai (1999)
Daidzein and genistein but not their glucosides are absorbed from the rat stomachFEBS Letters, 447
S. File (1980)
The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugsJournal of Neuroscience Methods, 2
S. File, H. Zangrossi, Fiona Sanders, P. Mabbutt (2005)
Raised corticosterone in the rat after exposure to the elevated plus-mazePsychopharmacology, 113
T. Lund, E. Lephart (2001)
Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-mazeBrain Research, 913
David E. Hartley +44-207-8486663 +44-207-8486660 david.2.hartley@kcl.ac.uk Jessica E. Edwards Claire E. Spiller Nazmul Alom Sonia Tucci Pallab Seth Mary L. Forsling Sandra E. File Psychopharmacology Research Unit, Centre for Neuroscience, Hodgkin Building, Kings College London, Guy's Campus, SE1 1UL, London, UK Rationale. Most commercial rodent diets are formulated with soya protein and therefore contain soya isoflavones. Isoflavones form one of the main classes of phytoestrogens and have been found to exert both oestrogenic and anti-oestrogenic effects on the central nervous system. The effects have not been limited to reproductive behaviour, but include effects on learning and anxiety and actions on the hypothalamo-pituitary axis. It is therefore possible that the soya content of diet could have significant effects on brain and behaviour and be an important source of between-laboratory variability. Objectives. To determine whether behaviour in two animal tests of anxiety, and stress hormone production, would differ between rats that were fed a diet which was free of soya isoflavones and other phytoestrogens (iso-free) and those that were fed a diet which contained 150 μg/g of the isoflavones genistein and daidzein (iso-150). This controlled diet has an isoflavone concentration similar to that in the maintenance diet routinely used in our institution. Methods. Male rats were randomly allocated to the iso-free and iso-150 diets and their body weights and food and water consumption were recorded for 14 days. They were then maintained on the same diets, but housed singly for 4 days, before testing in the social interaction and elevated plus-maze tests of anxiety. Corticosterone concentrations in both dietary groups were determined under basal conditions and after the stress of the two tests of anxiety. Vasopressin and oxytocin concentrations were determined after brief handling stress. Results. The groups did not differ in food or water intake, body weight or oxytocin concentrations. Compared with the rats fed the iso-free diet, the rats fed the iso-150 diet spent significantly less time in active social interaction and made a significantly lower percentage of entries onto the open arms of the plus-maze, indicating anxiogenic effects in both animal tests. The groups did not differ in their basal corticosterone concentrations, but the iso-150 group had significantly elevated stress-induced corticosterone concentrations. Stress-induced plasma vasopressin concentrations were also significantly elevated in the iso-150 diet group compared with the iso-free rats. Conclusions. Major changes in behavioural measures of anxiety and in stress hormones can result from the soya isoflavone content of rat diet. These changes are as striking as those seen following drug administration and could form an important source of variation between laboratories.
Psychopharmacology – Springer Journals
Published: Apr 1, 2003
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