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Akio Kihara, Y. Akiyama, Koreaki Ito (1998)
Different pathways for protein degradation by the FtsH/HflKC membrane-embedded protease complex: an implication from the interference by a mutant form of a new substrate protein, YccA.Journal of molecular biology, 279 1
M. Montano, K. Ekena, Régis Delage-Mourroux, Weiru Chang, Paolo Martini, B. Katzenellenbogen (1999)
An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens.Proceedings of the National Academy of Sciences of the United States of America, 96 12
K. Beckman, B. Ames (1998)
The free radical theory of aging matures.Physiological reviews, 78 2
D. Black, E. Solomon (1993)
The search for the familial breast/ovarian cancer gene.Trends in genetics : TIG, 9 1
E. Jupe, Xiao‐T. Liu, Kiehlbauch Jl, McClung Jk, Dell'orco Rt (1996)
The 3' untranslated region of prohibitin and cellular immortalization.Experimental cell research, 224 1
X. Liu, C. Stewart, R. King, D. Danner, R. Dell'orco, J. McClung (1994)
Prohibitin expression during cellular senescence of human diploid fibroblasts.Biochemical and biophysical research communications, 201 1
Gregor Steglich, W. Neupert, T. Langer (1999)
Prohibitins Regulate Membrane Protein Degradation by the m-AAA Protease in MitochondriaMolecular and Cellular Biology, 19
R. Sohal, R. Weindruch (1996)
Oxidative Stress, Caloric Restriction, and AgingScience, 273
Takaaki Sato, T. Sakamoto, K. Takita, H. Saito, K. Okui, Y. Nakamura (1993)
The human prohibitin (PHB) gene family and its somatic mutations in human tumors.Genomics, 17 3
M. Juhola, Z. Shah, L. Grivell, H. Jacobs (2000)
The mitochondrial inner membrane AAA metalloprotease family in metazoansFEBS Letters, 481
A. Martinez, D. Over, L. Armstrong, L. Manzano, R. Taylor, J. Chambers (1991)
Separation of two subpopulations of old human fibroblasts by mitochondria (rhodamine 123) fluorescence.Growth, development, and aging : GDA, 55 3
S. Tanno, I. Fukuda, Yoshinori Saito, K. Ogawa (1997)
Prohibitin Expression Is Decreased in the Regenerating Liver but Not in Chemically Induced Hepatic Tumors in RatsJapanese Journal of Cancer Research : Gann, 88
W. Snedden, H. Fromm (1997)
Characterization of the plant homologue of prohibitin, a gene associated with antiproliferative activity in mammalian cellsPlant Molecular Biology, 33
Ramgopal Nadimpalli, N. Yalpani, G. Johal, C. Simmons (2000)
Prohibitins, Stomatins, and Plant Disease Response Genes Compose a Protein Superfamily That Controls Cell Proliferation, Ion Channel Regulation, and Death*The Journal of Biological Chemistry, 275
T. Hagen, R. Ingersoll, J. Lykkesfeldt, Jiankang Liu, C. Wehr, V. Vinarský, J. Bartholomew, B. Ames (1999)
(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rateThe FASEB Journal, 13
G. Casari, M. Fusco, S. Ciarmatori, M. Zeviani, M. Mora, Patricio Fernandez, G. Michele, A. Filla, S. Cocozza, R. Marconi, A. Dürr, B. Fontaine, A. Ballabio (1998)
Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial MetalloproteaseCell, 93
J. Noble, M. Innis, E. Koonin, K. Rudd, F. Banuett, Ira Herskowitz (1993)
The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain.Proceedings of the National Academy of Sciences of the United States of America, 90 22
Nektarios Tavernarakis, M. Driscoll, N. Kyrpides (1999)
The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins.Trends in biochemical sciences, 24 11
H. Shim, B. Lewis, C. Dolde, Q. Li, C. Wu, Y. Chun, C. Dang (1997)
Myc target genes in neoplastic transformation.Current topics in microbiology and immunology, 224
D. Wallace (1999)
Mitochondrial diseases in man and mouse.Science, 283 5407
A. Kihara, Y. Akiyama, Koreaki Ito (1996)
A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY.The EMBO Journal, 15
L. Nijtmans, M. Sanz, M. Bučko, M. Farhoud, M. Feenstra, Gertjan Hakkaart, M. Zeviani, L. Grivell (2001)
Shy1p occurs in a high molecular weight complex and is required for efficient assembly of cytochrome c oxidase in yeastFEBS Letters, 498
H. Atamna, A. Paler-Martinez, B. Ames (2000)
N-t-Butyl Hydroxylamine, a Hydrolysis Product of α-Phenyl-N-t-butyl Nitrone, Is More Potent in Delaying Senescence in Human Lung Fibroblasts*The Journal of Biological Chemistry, 275
I. Byrjalsen, P. Larsen, S. Fey, L. Nilas, M. Larsen, C. Christiansen (1999)
Two-dimensional gel analysis of human endometrial proteins: characterization of proteins with increased expression in hyperplasia and adenocarcinoma.Molecular human reproduction, 5 8
C. Dang, G. Semenza (1999)
Oncogenic alterations of metabolism.Trends in biochemical sciences, 24 2
P. Nagley, Y. Wei (1998)
Ageing and mammalian mitochondrial genetics.Trends in genetics : TIG, 14 12
K. Khrapko, N. Bodyak, W. Thilly, N. Orsouw, X. Zhang, H. Coller, T. Perls, M. Upton, J. Vijg, J. Wei (1999)
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions.Nucleic acids research, 27 11
McClung Jk, E. Jupe, Liu Xt, Dell'orco Rt (1995)
Prohibitin: Potential role in senescence, development, and tumor suppressionExperimental Gerontology, 30
K. Inoue, K. Nakada, A. Ogura, K. Isobe, Yu-ichi Goto, I. Nonaka, J. Hayashi (2000)
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotesNature Genetics, 26
M. Asamoto, S. Cohen (1994)
Prohibition gene is overexpressed but not mutated in rat bladder carcinomas and cell linesCancer Letters, 83
R. Rasmussen, H. Ji, J. Eddes, R. Moritz, G. Reid, R. Simpson, D. Dorow (1998)
Two‐dimensional electrophoretic analysis of mixed lineage kinase 2 N‐terminal domain binding proteinsELECTROPHORESIS, 19
W. Cliby, G. Sarkar, S. Ritland, L. Hartmann, K. Podratz, R. Jenkins (1993)
Absence of prohibitin gene mutations in human epithelial ovarian tumors.Gynecologic oncology, 50 1
A. LópezdeMunain (1998)
Classification of mitochondrial diseasesRevista De Neurologia
T. Hagen, D. Yowe, J. Bartholomew, C. Wehr, Katherine Do, J. Park, B. Ames (1997)
Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase.Proceedings of the National Academy of Sciences of the United States of America, 94 7
R. Dell'orco, J. McClung, E. Jupe, X-T. Liu (1996)
Prohibitin and the senescent phenotypeExperimental Gerontology, 31
E. Jupe, Xiao‐T. Liu, Kiehlbauch Jl, McClung Jk, Dell'orco Rt (1996)
Prohibitin in breast cancer cell lines: loss of antiproliferative activity is linked to 3' untranslated region mutations.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7 7
J. Müller‐Höcker, K. Schneiderbanger, F. Stefani, B. Kadenbach (1992)
Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing--a cytochemical-immunohistochemical study.Mutation research, 275 3-6
W. Thompson, A. Sanbuissho, G. Lee, E. Anderson (1997)
Steroidogenic acute regulatory (StAR) protein (p25) and prohibitin (p28) from cultured rat ovarian granulosa cells.Journal of reproduction and fertility, 109 2
L. Nijtmans, Liesbeth Jong, M. Sanz, P. Coates, J. Berden, J. Back, A. Muijsers, H. Spek, L. Grivell (2000)
Prohibitins act as a membrane‐bound chaperone for the stabilization of mitochondrial proteinsThe EMBO Journal, 19
F. Rastinejad, H. Blau (1993)
Genetic complementation reveals a novel regulatory role for 3′ untranslated regions in growth and differentiationCell, 72
M. Terashima, K.M. Kim, T. Adachi, P. Nielsen, M. Reth, G. Köhler, M. Lamers (1994)
The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin‐related protein.The EMBO Journal, 13
Katherine Williams, C. Chubb, E. Huberman, C. Giometti (1997)
Analysis of differential protein expression in normal and neoplastic human breast epithelial cell linesELECTROPHORESIS, 19
G. Martin, S. Austad, T. Johnson (1996)
Genetic analysis of ageing: role of oxidative damage and environmental stressesNature Genetics, 13
D. Volonté, Ferruccio Galbiati, Shengwen Li, K. Nishiyama, T. Okamoto, M. Lisanti (1999)
Flotillins/Cavatellins Are Differentially Expressed in Cells and Tissues and Form a Hetero-oligomeric Complex with Caveolins in VivoThe Journal of Biological Chemistry, 274
Sheng Wang, N. Nath, Matthew Adlam, S. Chellappan (1999)
Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F functionOncogene, 18
Josef Müller, Höcker, D. Aust, H. Rohrbach, J. Napiwotzky, A. Reith, Thomas, A., Link, P. Seibel, D. Hölzel, B. Kadenbach (1997)
Defects of the respiratory chain in the normal human liver and in cirrhosis during agingHepatology, 26
A. Kihara, Y. Akiyama, Koreaki Ito (1995)
FtsH is required for proteolytic elimination of uncomplexed forms of SecY, an essential protein translocase subunit.Proceedings of the National Academy of Sciences of the United States of America, 92 10
W. Orr, R. Sohal (1994)
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.Science, 263 5150
D. Eveleth, J. Marsh (1986)
Sequence and expression of the Cc gene, a member of the dopa decarboxylase gene cluster of Drosophila: possible translational regulation.Nucleic acids research, 14 15
Taka-Aki Sato, H. Saito, J. Swensen, Arnold Olifant, C. Wood, D. Danner, T. Sakamoto, K. Takita, F. Kasumi, Y. Miki, M. Skolnick, Y. Nakamura (1992)
The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer.Cancer research, 52 6
J. White, D. Ledbetter, R. Eddy, T. Shows, D. Stewart, M. Nuell, V. Friedman, C. Wood, G. Owens, J. McClung (1991)
Assignment of the human prohibitin gene (PHB) to chromosome 17 and identification of a DNA polymorphism.Genomics, 11 1
E. Jupe, X. Liu, J. Kiehlbauch, J. McClung, R. Dell'orco (1995)
Prohibitin antiproliferative activity and lack of heterozygosity in immortalized cell lines.Experimental cell research, 218 2
E. Ikonen, K. Fiedler, R. Parton, K. Simons (1995)
Prohibitin, an antiproliferative protein, is localized to mitochondriaFEBS Letters, 358
K. Berger, M. Yaffe (1998)
Prohibitin Family Members Interact Genetically with Mitochondrial Inheritance Components in Saccharomyces cerevisiaeMolecular and Cellular Biology, 18
Rebecca Osthus, Hyunsuk Shim, Sunkyu Kim, Qing Li, R. Reddy, Mita Mukherjee, Yi Xu, Diane Wonsey, Linda Lee, C. Dang (2000)
Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc*The Journal of Biological Chemistry, 275
Qin Chen, Ann Fischer, Joshua Reagan, Liang-Jun Yan, B. Ames (1995)
Oxidative DNA damage and senescence of human diploid fibroblast cells.Proceedings of the National Academy of Sciences of the United States of America, 92 10
J. McClung, R. King, L. Walker, D. Danner, M. Nuell, Charles Stewart, R. Dell'orco (1992)
Expression of prohibitin, an antiproliferative proteinExperimental Gerontology, 27
P. Coates, P. Coates, R. Nenutil, A. McGregor, S. Picksley, D. Crouch, P. Hall, E. Wright, E. Wright (2001)
Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.Experimental cell research, 265 2
M. Nuell, D. Stewart, L. Walker, V. Friedman, C. Wood, G. Owens, J. Smith, E. Schneider, R. Orco, C. Lumpkin (1991)
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cellsMolecular and Cellular Biology, 11
Elena Dibrov, Stan Fu, B. Lemire (1998)
The Saccharomyces cerevisiae TCM62 Gene Encodes a Chaperone Necessary for the Assembly of the Mitochondrial Succinate Dehydrogenase (Complex II)*The Journal of Biological Chemistry, 273
Philip Coates, Derek Jamieson, Katherine Smart, Alan Prescott, Peter Hall (1997)
The prohibitin family of mitochondrial proteins regulate replicative lifespanCurrent Biology, 7
M. Hoyt, D. Knight, A. Das, H. Miller, H. Echols (1982)
Control of phage λ development by stability and synthesis of cll protein: Role of the viral clll and host hflA, himA and himD genesCell, 31
A. Kihara, Koreaki Ito (1998)
Translocation, Folding, and Stability of the HflKC Complex with Signal Anchor Topogenic Sequences*The Journal of Biological Chemistry, 273
M. Ansari-Lari, Ying Shen, D. Muzny, William Lee, R. Gibbs (1997)
Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.Genome research, 7 3
Takayuki Ozawa (1997)
Genetic and functional changes in mitochondria associated with aging.Physiological reviews, 77 2
S. Welburn, N. Murphy (1998)
Prohibitin and RACK homologues are up-regulated in trypanosomes induced to undergo apoptosis and in naturally occurring terminally differentiated formsCell Death and Differentiation, 5
Although originally identified as putative negative regulators of the cell cycle, recent studies have demonstrated that the PHB proteins act as a chaperone in the assembly of subunits of mitochondrial respiratory chain complexes. The two PHB proteins, Phb1p and Phb2p, are located in the mitochondrial inner membrane where they form a large complex that represents a novel type of membrane-bound chaperone. On the basis of its native molecular weight, the PHB-complex should contain 12-14 copies of both Phb1p and Phb2p. The PHB complex binds directly to newly synthesised mitochondrial translation products and stabilises them against degradation by membrane-bound metalloproteases belonging to the family of mitochondrial triple-A proteins. Sequence homology assigns Phb1p and Phb2p to a family of proteins which also contains stomatins, HflKC, flotillins and plant defence proteins. However, to date only the bacterial HflKC proteins have been shown to possess a direct functional homology with the PHB complex. Previously assigned actions of the PHB proteins, including roles in tumour suppression, cell cycle regulation, immunoglobulin M receptor binding and apoptosis seem unlikely in view of any hard evidence in their support. Nevertheless, because the proteins are probably indirectly involved in ageing and cancer, we assess their possible role in these processes. Finally, we suggest that the original name for these proteins, the prohibitins, should be amended to reflect their roles as proteins that hold badly formed subunits, thereby keeping the nomenclature already in use but altering its meaning to reflect their true function more accurately.
Cellular and Molecular Life Sciences – Springer Journals
Published: Jan 1, 2002
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