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M. Raff, Robert Miller, M. Noble (1983)
A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture mediumNature, 303
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Improved patch‐clamp techniques for high‐resolution current recording from cells and cell‐free membrane patchesPflügers Arch, 391
N. Davies, H. Lux, M. Morad (1988)
Site and mechanism of activation of proton‐induced sodium current in chick dorsal root ganglion neurones.The Journal of Physiology, 400
J. Trotter, D. Bitter‐Suermann, M. Schachner (1989)
Differentiation‐regulated loss of the polysialylated embryonic form and expression of the different polypeptides of the neural cell adhesion molecule by cultured oligodendrocytes and myelinJournal of Neuroscience Research, 22
Z. Ahmed (1988)
Expression of membrane currents in rat neocortical neurons in serum-free culture. I. Inward currents.Brain research, 468 2
M. Schachner, S. Kim, R. Zehnle (1981)
Developmental expression in central and peripheral nervous system of oligodendrocyte cell surface antigens (O antigens) recognized by monoclonal antibodies.Developmental biology, 83 2
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Kuhlmann‐Krieg Kuhlmann‐Krieg, Sommer Sommer, Schachner Schachner (1988)
Ultrastructural features of cultured oligodendrocytes expressing stage‐specific cell surface antigensDev Brain Res, 39
Konnerth Konnerth, Lux Lux, Morad Morad (1987)
Proton‐induced transformation of calcium channel in chick dorsal root ganglion cellsJ Physiol Lond, 386
R. Grantyn, M. Perouansky, A. Rodríguez‐Tébar, H. Lux (1989)
Expression of depolarizing voltage- and transmitter-activated currents in neuronal precursor cells from the rat brain is preceded by a proton-activated sodium current.Brain research. Developmental brain research, 49 1
J. Trotter, M. Schachner (1989)
Cells positive for the O4 surface antigen isolated by cell sorting are able to differentiate into astrocytes or oligodendrocytes.Brain research. Developmental brain research, 46 1
R. Grantyn, H. Lux (1988)
Similarity and mutual exclusion of NMDA- and proton-activated transient Na+-currents in rat tectal neuronsNeuroscience Letters, 89
K. Gottmann, I. Dietzel, H. Lux, C. Ruedel (1989)
Proton-induced Na+ current develops prior to voltage-dependent Na+ and Ca2+ currents in neuronal precursor cells from chick dorsal root ganglionNeuroscience Letters, 99
(1989)
ronal precursor cells from the rat brain express proton - activated sodium currents prior to voltage - and transmitter - activated cationic inward currents
Z. Ahmed (1988)
Expression of membrane currents in rat neocortical neurons in serum-free culture. II. Outward currents.Brain research, 468 2
G. Levi, F. Aloisi, G. Wilkin (1987)
Differentiation of cerebellar bipotential glial preecurosrs into oligodendrocytes in primary culture: Development profile of surface antigens and mitotic activityJournal of Neuroscience Research, 18
Helmut Kettenmann, K. Backus, M. Schachner (1984)
Aspartate, glutamate and γ-aminobutyric acid depolarize cultured astrocytesNeuroscience Letters, 52
J. Nieke, I. Sommer, M. Schachner (1988)
Stage-specific cell-surface antigens of oligodendrocytes in the peripheral nervous system. Expression during development and regeneration and in myelin-deficient mutants.Brain research, 467 2
Iris Sommer, M. Schachner (1982)
Cell that are O4 antigen-positive and O1 antigen-negative differentiate into O1 antigen-positive oligodendrocytesNeuroscience Letters, 29
Sommer Sommer, Schachner Schachner (1981)
Developmental expression in central and peripheral nervous system of oligodendrocyte antigens (O antigens) recognized by monoclonal antibodyDev. Biol., 83
(1989)
Proton-induced Na’ current is present in neuronal precursor cells prior to the devclopment of voltage-dependent Naf current and high-voltage activated Ca’ ’ current
H. Kettenmann, R. Orkand, M. Schachner (1983)
Coupling among identified cells in mammalian nervous system cultures, 3
A. Marty, E. Neher (1983)
Tight-Seal Whole-Cell Recording
A. Konnerth, H. Lux, M. Morad (1987)
Proton‐induced transformation of calcium channel in chick dorsal root ganglion cells.The Journal of Physiology, 386
(1984)
Backus KH,
Ahmed Ahmed (1988)
Expression of membrane currents in rat neocortical neurons in serum‐free culture. II. Outward currentsDev Brain Res, 40
H. Kettenmann, K. Backus, M. Schachner (1984)
Aspartate, glutamate and gamma-aminobutyric acid depolarize cultured astrocytes.Neuroscience letters, 52 1-2
Trotter Trotter, Schachner Schachner (1989)
Cells positive for the O4 surface antigen isolated by cell sorting are able to differentiate into astrocytes or oligodendrocytesDev Brain Res, 46
H. Sontheimer, H. Kettenmann (1988)
Heterogeneity of potassium currents in cultured oligodendrocytesGlia, 1
Z. Ahmed, John Connor, David Tank, R. Fellows (1986)
Expression of membrane currents in rat diencephalic neurons in serum-free culture.Brain research, 393 2
O. Krishtal, V. Pidoplichko (1980)
A receptor for protons in the nerve cell membraneNeuroscience, 5
S. Kuhlmann-Krieg, I. Sommer, M. Schachner (1988)
Ultrastructural features of cultured oligodendrocytes expressing stage-specific cell-surface antigens.Brain research, 467 2
Davies Davies, Lux Lux, Morad Morad (1988)
Site and mechanism of activation of proton‐induced sodium current in chick dorsal root ganglion neuronesJ Physiol Lond., 400
(1982)
Cells that are 0 4 antigen-positive
Kurt Gottmann, Irmgard Dietzel, H. Lux, S. Huck, Hermann Rohrer (1988)
Development of inward currents in chick sensory and autonomic neuronal precursor cells in culture, 8
Ahmed Ahmed, Connor Connor, Tank Tank, Fellows Fellows (1986)
Expression of membrane currents in rat diencephalic neurons in serum‐free cultureDev Brain Res, 28
H. Sontheimer, J. Trotter, M. Schachner, H. Kettenmann (1989)
Channel expression correlates with differentiation stage during the development of Oligodendrocytes from their precursor cells in cultureNeuron, 2
Neurons and oligodendrocytes, but not type I astrocytes and Schwann cells, generate large Na+ currents in response to a step increase of (H+). Proton‐activated Na+ channels are the first cationic channels expressed in neuronal precursor cells from the mammalian brain. Glial precursor cells cultured from mouse brain are also capable of generating Na+ currents in response to step acidification (INa(H)). With further development along the oligodendrocyte lineage, this property is retained, whereas voltage‐activated Na+ and K+ currents disappear. Comparing INa(H) of oligodendrocytes with INa(H) of their precursor cells did not reveal a difference in current amplitude, suggesting a higher density of INa(H) channels on the (smaller) precursor cells. The properties of INa(H) in glial precursor cells and oligodendrocytes are similar to those of neurons, with respect to activation conditions, time course, and the effect of extracellular Ca2+ concentrations. The results are consistent with previous observations which showed that oligodendrocytes partially preserve their chemically activated, but completely lose their voltage‐activated, ion channels.
Journal of Neuroscience Research – Wiley
Published: Dec 1, 1989
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