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Pharmacokinetics and metabolic effects of triamcinolone acetonide and their possible relationships to glucocorticoid‐induced laminitis in horses

Pharmacokinetics and metabolic effects of triamcinolone acetonide and their possible... Experiments were performed to establish the pharmacokinetics of triamcinolone acetonide and the effects of the glucocorticoid on glucose metabolism in horses. The pharmacokinetics after intravenous (i.v.) dosing was best described by a three‐compartment open model. There was rapid distribution from the central compartment followed by two phases of elimination. The half‐life of the rapid elimination phase was 83.5 min and of the slower phase was 12 h. The term (Vss/Vc)−1was 12.3 indicating extensive distribution into the tissues. Triamcinolone acetonide given i.v. or intramuscularly (i.m.) induced a prolonged period of hyperglycaemia, hyperinsulinaemia and hypertriglyceridaemia. Significant changes in plasma glucagon and serum non‐esterified fatty acids were not observed. These observations suggest that the hyperglycaemia was a result of decreased glucose utilization by tissues and increased gluconeogenesis. The effects on glucose metabolism persisted for 3–4 days after triamcinolone was given i.m. at 0.05 mg/kg, the upper limit of the recommended dose range, and for 8 days when given at 0.2 mg/kg. These observations, together with recent evidence implicating inhibition of glucose metabolism in the pathogenesis of equine laminitis, indicated that triamcinolone‐induced laminitis may be associated with the long duration of action of the glucocorticoid when higher than recommended doses or when repeated doses are given. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Veterinary Pharmacology & Therapeutics Wiley

Pharmacokinetics and metabolic effects of triamcinolone acetonide and their possible relationships to glucocorticoid‐induced laminitis in horses

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References (13)

Publisher
Wiley
Copyright
Copyright © 2000 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0140-7783
eISSN
1365-2885
DOI
10.1111/j.1365-2885.2000.00288.x
Publisher site
See Article on Publisher Site

Abstract

Experiments were performed to establish the pharmacokinetics of triamcinolone acetonide and the effects of the glucocorticoid on glucose metabolism in horses. The pharmacokinetics after intravenous (i.v.) dosing was best described by a three‐compartment open model. There was rapid distribution from the central compartment followed by two phases of elimination. The half‐life of the rapid elimination phase was 83.5 min and of the slower phase was 12 h. The term (Vss/Vc)−1was 12.3 indicating extensive distribution into the tissues. Triamcinolone acetonide given i.v. or intramuscularly (i.m.) induced a prolonged period of hyperglycaemia, hyperinsulinaemia and hypertriglyceridaemia. Significant changes in plasma glucagon and serum non‐esterified fatty acids were not observed. These observations suggest that the hyperglycaemia was a result of decreased glucose utilization by tissues and increased gluconeogenesis. The effects on glucose metabolism persisted for 3–4 days after triamcinolone was given i.m. at 0.05 mg/kg, the upper limit of the recommended dose range, and for 8 days when given at 0.2 mg/kg. These observations, together with recent evidence implicating inhibition of glucose metabolism in the pathogenesis of equine laminitis, indicated that triamcinolone‐induced laminitis may be associated with the long duration of action of the glucocorticoid when higher than recommended doses or when repeated doses are given.

Journal

Journal of Veterinary Pharmacology & TherapeuticsWiley

Published: Oct 1, 2000

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