Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Koob, Floyd Bloom (1983)
Behavioural effects of opioid peptides.British medical bulletin, 39 1
N. Goeders, J. Lane, James Smith (1984)
Self-administration of methionine enkephalin into the nucleus accumbensPharmacology Biochemistry and Behavior, 20
H. Pettit, A. Ettenberg, F. Bloom, G. Koob (2004)
Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in ratsPsychopharmacology, 84
M. Olds (1982)
Reinforcing effects of morphine in the nucleus accumbensBrain Research, 237
L. Stinus, G. Koob, Nicholas Ling, Floyd Bloom, M. Moal (1980)
Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.Proceedings of the National Academy of Sciences of the United States of America, 77 4
J. Weeks, R. Collins (1976)
Changes in morphine self-administration in rats induced by prostaglandin E1 and naloxone.Prostaglandins, 12 1
Ann Kelle, L. Stinus, S. Iversen (1980)
Interactions between d-Ala-Met-enkephalin, A10 dopaminergic neurones, and spontaneous behaviour in the ratBehavioural Brain Research, 1
M. Galloway, R. Roth (1983)
Neuropharmacology of 3-isobutylmethylxanthine: effects on central noradrenergic systems in vivo.The Journal of pharmacology and experimental therapeutics, 227 1
G. Bianchi, R. Fiocchi, A. Tavani, L. Manara (1982)
Quaternary narcotic antagonists' relative ability to prevent antinociception and gastrointestinal transit inhibition in morphine-treated rats as an index of peripheral selectivity.Life sciences, 30 22
R. Yokel, R. Wise (1975)
Increased lever pressing for amphetamine after pimozide in rats: implications for a dopamine theory of reward.Science, 187 4176
R. Valentino, J. Katz, F. Medzihradsky, J. Woods (1983)
Receptor binding, antagonist, and withdrawal precipitating properties of opiate antagonists.Life sciences, 32 25
M. Bozarth, R. Wise (1981)
Intracranial self-administration of morphine into the ventral tegmental area in rats.Life sciences, 28 5
A. Ettenberg, H. Pettit, F. Bloom, G. Koob (2004)
Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systemsPsychopharmacology, 78
P. Kalivas, David Stanley, Erik Widerlöv, G. Breese, A. Prange (1983)
Enkephalin action on the mesolimbic system: a dopamine-dependent and a dopamine-independent increase in locomotor activity.The Journal of pharmacology and experimental therapeutics, 227 1
R. Yokel, R. Wise (1976)
Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in ratsPsychopharmacology, 48
G. Koob, H. Pettit, A. Ettenberg, F. Bloom (1984)
Effects of opiate antagonists and their quaternary derivatives on heroin self-administration in the rat.The Journal of pharmacology and experimental therapeutics, 229 2
L. Pellegrino, A. Cushman (1967)
stereotaxic atlas of the rat brain
R. Pickens, R. Meisch, T. Thompson (1978)
Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs
M. Bozarth, R. Wise (1983)
Neural substrates of opiate reinforcementProgress in Neuro-Psychopharmacology and Biological Psychiatry, 7
D. Roberts, M. Corcoran, H. Fibiger (1977)
On the role of ascending catecholaminergic systems in intravenous self-administration of cocainePharmacology Biochemistry and Behavior, 6
A. Pert, C. Sivit (1977)
Neuroanatomical focus for morphine and enkaphalin-induced hypermotilityNature, 265
S. Glick, R. Cox, A. Crane (2004)
Changes in morphine self-administration and morphine dependence after lesions of the caudate nucleus in ratsPsychopharmacologia, 41
Michael Britt, R. Wise (1983)
Ventral tegmental site of opiate reward: Antagonism by a hydrophilic opiate receptor blockerBrain Research, 258
James Russell, P. Bass, L. Goldberg, C. Schuster, H. Merz (1982)
Antagonism of gut, but not central effects of morphine with quaternary narcotic antagonists.European journal of pharmacology, 78 3
D. Roberts, G. Koob, P. Klonoff, H. Fibiger (1980)
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbensPharmacology Biochemistry and Behavior, 12
F. Vaccarino, K. Franklin (1982)
Self-stimulation and circling reveal functional differences between medial and lateral substantia nigraBehavioural Brain Research, 5
F. Vaccarino, H. Pettit, F. Bloom, G. Koob (1985)
Effects of intracerebroventricular administration of methyl naloxonium chloride on heroin self-administration in the ratPharmacology Biochemistry and Behavior, 23
C. Pert, A. Pert, J. Chang, B. Fong (1976)
(D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic.Science, 194 4262
S. Goldberg, J. Woods, C. Schuster (1971)
Nalorphine-induced changes in morphine self-administration in rhesus monkeys.The Journal of pharmacology and experimental therapeutics, 176 2
J. Fink, Gerard Smith (1980)
Mesolimbicocortical dopamine terminal fields are necessary for normal locomotor and investigatory exploration in ratsBrain Research, 199
M. Wilson, C. Schuster (2004)
The effects of chlorpromazine on psychomotor stimulant self-administration in the Rhesus monkeyPsychopharmacologia, 26
213 86 86 1 2 Franco J. Vaccarino Floyd E. Bloom George F. Koob Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation 92037 La Jolla California USA Division of Life Sciences Scarborough Campus, University of Toronto 1265 Military Trail MIC 1A4 Scarborough Ontario Canada Abstract A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebrally to rats trained to self-administer heroin intravenously. Increases in intravenous (IV) heroin self-administration rates were found following injections of low doses of MN into the nucleus accumbens (N.Acc), but not following injections of low doses of MN into the ventral tegmental area (VTA). These results were interpreted to suggest that the rewarding properties of IV heroin were decreased following N.Acc opiate receptor blockade. The relative insensitivity of the VTA to MN treatment was taken to suggest that VTA opiate receptors are either not essential or play a secondary role in mediating IV heroin self-administration. The present data support the notion that post-synaptic N.Acc opiate receptors play a crucial role in maintaining IV heroin self-administration.
Psychopharmacology – Springer Journals
Published: Mar 1, 1985
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.