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Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat 213 86 86 1 2 Franco J. Vaccarino Floyd E. Bloom George F. Koob Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation 92037 La Jolla California USA Division of Life Sciences Scarborough Campus, University of Toronto 1265 Military Trail MIC 1A4 Scarborough Ontario Canada Abstract A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebrally to rats trained to self-administer heroin intravenously. Increases in intravenous (IV) heroin self-administration rates were found following injections of low doses of MN into the nucleus accumbens (N.Acc), but not following injections of low doses of MN into the ventral tegmental area (VTA). These results were interpreted to suggest that the rewarding properties of IV heroin were decreased following N.Acc opiate receptor blockade. The relative insensitivity of the VTA to MN treatment was taken to suggest that VTA opiate receptors are either not essential or play a secondary role in mediating IV heroin self-administration. The present data support the notion that post-synaptic N.Acc opiate receptors play a crucial role in maintaining IV heroin self-administration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

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References (31)

Publisher
Springer Journals
Copyright
Copyright © 1985 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF00431681
Publisher site
See Article on Publisher Site

Abstract

213 86 86 1 2 Franco J. Vaccarino Floyd E. Bloom George F. Koob Division of Preclinical Neuroscience and Endocrinology Scripps Clinic and Research Foundation 92037 La Jolla California USA Division of Life Sciences Scarborough Campus, University of Toronto 1265 Military Trail MIC 1A4 Scarborough Ontario Canada Abstract A quaternary derivative of naloxone, methyl naloxonium chloride (MN), was administered intracerebrally to rats trained to self-administer heroin intravenously. Increases in intravenous (IV) heroin self-administration rates were found following injections of low doses of MN into the nucleus accumbens (N.Acc), but not following injections of low doses of MN into the ventral tegmental area (VTA). These results were interpreted to suggest that the rewarding properties of IV heroin were decreased following N.Acc opiate receptor blockade. The relative insensitivity of the VTA to MN treatment was taken to suggest that VTA opiate receptors are either not essential or play a secondary role in mediating IV heroin self-administration. The present data support the notion that post-synaptic N.Acc opiate receptors play a crucial role in maintaining IV heroin self-administration.

Journal

PsychopharmacologySpringer Journals

Published: Mar 1, 1985

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