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RNA on the move: the mRNA localization pathway.

RNA on the move: the mRNA localization pathway. IOLOGISTShave long been fascinated by how cells target proteins to specific intraeellular compartments and maintain their localized distributions. The problem of how proteins are sorted to particular membranebound organelles has been the focus of considerable effort in the last decade. As a result, a good deal is known about protein sorting signals (48, 54), the protein machinery needed for budding and docking vesicles in the secretory pathway (48, 54), and the mechanisms for transporting vesicles along microtubules and actin filaments within the cytoplasm (55). In contrast to the relative wealth of information concerning the sorting of membrane proteins, very little is understood about how cytosolic proteins are partitioned within the cytoplasm. However, it has become increasingly clear that the transport of mRNAs, and not the translated proteins themselves, constitutes an important means of localizing cytosolic proteins (Table I). The first evidence for cytoplasmic RNA localization came from the finding that actin transcripts are unevenly distributed in the ascidian embryo (29). Shortly thereafter, several maternal mRNAs were identified in Xenopus (53) and Drosophila (17) that are localized during oogenesis. More recently, localized mRNAs have been discovered in somatic cells (Table I), making it clear that mRNA localization serves as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

RNA on the move: the mRNA localization pathway.

J E Wilhelm; R D Vale
The Journal of Cell Biology , Volume 123 (2): 269 – Oct 15, 1993
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References (60)

Publisher
Rockefeller University Press
Copyright
Copyright © 1993 by The Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb.123.2.269
Publisher site
See Article on Publisher Site

Abstract

IOLOGISTShave long been fascinated by how cells target proteins to specific intraeellular compartments and maintain their localized distributions. The problem of how proteins are sorted to particular membranebound organelles has been the focus of considerable effort in the last decade. As a result, a good deal is known about protein sorting signals (48, 54), the protein machinery needed for budding and docking vesicles in the secretory pathway (48, 54), and the mechanisms for transporting vesicles along microtubules and actin filaments within the cytoplasm (55). In contrast to the relative wealth of information concerning the sorting of membrane proteins, very little is understood about how cytosolic proteins are partitioned within the cytoplasm. However, it has become increasingly clear that the transport of mRNAs, and not the translated proteins themselves, constitutes an important means of localizing cytosolic proteins (Table I). The first evidence for cytoplasmic RNA localization came from the finding that actin transcripts are unevenly distributed in the ascidian embryo (29). Shortly thereafter, several maternal mRNAs were identified in Xenopus (53) and Drosophila (17) that are localized during oogenesis. More recently, localized mRNAs have been discovered in somatic cells (Table I), making it clear that mRNA localization serves as

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: Oct 15, 1993

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