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- Publisher
- Oxford University Press
- Copyright
- Copyright © 2015 Maryland Psychiatric Research Center and Oxford University Press
- ISSN
- 0586-7614
- eISSN
- 1745-1701
- DOI
- schizophreniabulletin;29/4/747
- Publisher site
- See Article on Publisher Site
Abstract
Recently, interventions for the psychotic prodrome have gained considerable interest. The goal of early interventions for prepsychotic, but symptomatic, individuals is to reduce disability and impairment by ameliorating subpsychotic symptoms and, potentially, preventing the progression into a full-blown psychotic disorder. However, several central questions regarding early interventions for the psychotic prodrome require clarification: Is it possible to prevent or to delay the onset of a psychotic disorder by intervening in the prodromal state? Is it possible to alter the natural course of the illness; i.e., to reduce subsequent symptom severity, relapse rates, treatment refractoriness, and/or functional disability, by treating subsyndromal symptoms? What is the relationship between treatment response of prodromal symptoms or specific symptom clusters and the prevention of disease progression or improvement of functional outcome? In the context of these questions, different treatment models and trial designs are presented, focusing on patient selection, target symptoms, interventions, control conditions, outcome measures, trial duration, and exit strategies, as well as statistical and ethical considerations. Finally, the methodology of completed and ongoing intervention trials in putative prodromal populations is discussed. Key words Schizophrenia psychosis prodrome prevention trial design methodology © Oxford University Press « Previous | Next Article » Table of Contents This Article Schizophr Bull (2003) 29 (4): 747-756. » Abstract Free Full Text (PDF) Free Classifications Articles Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Kane, J. M. Articles by Correll, C. U. Search for related content PubMed PubMed citation Articles by Kane, J. M. Articles by Krystal, J. Articles by Correll, C. U. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? 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Journal
Schizophrenia Bulletin – Oxford University Press
Published: Jan 1, 2003