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Pathogenesis of giant cell arteritis

Pathogenesis of giant cell arteritis GENE G. HUNDER, J. T. LIE, JORG J. GORONZY, and CORNELIA M. WEYAND The actinic hypothesis generates more heat than light In a recent Current Comment published in Arthritis and Rheumatism (l), O’Brien and Regan review their concept of the pathogenesis of giant cell arteritis (GCA) and emphasize their commitment to the ‘‘actinic hypothesis.” This hypothesis proposes that the primary causative lesion in GCA is an alteration or degeneration of the elastic lamina of the temporal artery caused by solar radiation. O’Brien and Regan believe the degenerated elastin then triggers the development of the arteritis, and cannot understand why others do not share their enthusiasm for this idea. For many years elastic tissues of the aorta and its proximal branches have been thought to be somehow involved in the development of GCA (2). Various investigators have noted that the inflammatory reactions in positive biopsy specimens often appear more intense around the internal elastic lamina of the temporal artery (2-4). Multinucleated giant cells, which are characteristic of the disease, are often in direct ____- From the Division of Rheumatology, Department of Medicine, Mayo Clinic and Mayo Medical School, Rochester, Minnesota; and the Department of Pathology, University of California, Davis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis & Rheumatism Wiley

Pathogenesis of giant cell arteritis

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References (56)

Publisher
Wiley
Copyright
Copyright © 1993 American College of Rheumatology
ISSN
0004-3591
eISSN
1529-0131
DOI
10.1002/art.1780360604
Publisher site
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Abstract

GENE G. HUNDER, J. T. LIE, JORG J. GORONZY, and CORNELIA M. WEYAND The actinic hypothesis generates more heat than light In a recent Current Comment published in Arthritis and Rheumatism (l), O’Brien and Regan review their concept of the pathogenesis of giant cell arteritis (GCA) and emphasize their commitment to the ‘‘actinic hypothesis.” This hypothesis proposes that the primary causative lesion in GCA is an alteration or degeneration of the elastic lamina of the temporal artery caused by solar radiation. O’Brien and Regan believe the degenerated elastin then triggers the development of the arteritis, and cannot understand why others do not share their enthusiasm for this idea. For many years elastic tissues of the aorta and its proximal branches have been thought to be somehow involved in the development of GCA (2). Various investigators have noted that the inflammatory reactions in positive biopsy specimens often appear more intense around the internal elastic lamina of the temporal artery (2-4). Multinucleated giant cells, which are characteristic of the disease, are often in direct ____- From the Division of Rheumatology, Department of Medicine, Mayo Clinic and Mayo Medical School, Rochester, Minnesota; and the Department of Pathology, University of California, Davis

Journal

Arthritis & Rheumatism – Wiley

Published: Jun 1, 1993

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