Access the full text.
Sign up today, get DeepDyve free for 14 days.
Hamill Hamill, Marty Marty, Neher Neher, Sackmann Sackmann, Sigworth Sigworth (1981)
Improved patch‐clamp techniques for high‐resolution current recording from cells and cell‐free membrane patchesPflügers Archiv, 391
R. Miles, K. Tóth, A. Gulyás, N. Hájos, T. Freund (1996)
Differences between Somatic and Dendritic Inhibition in the HippocampusNeuron, 16
I. Módy, Y. Koninck, T. Otis, I. Soltesz (1994)
Bridging the cleft at GABA synapses in the brainTrends in Neurosciences, 17
R. Pearce (1993)
Physiological evidence for two distinct GABAA responses in rat hippocampusNeuron, 10
Mccarren Mccarren, Alger Alger (1985)
Use‐dependent depression of IPSPs in rat hippocampal cells in vitroJournal of Neurophysiology, 53
Zixiu Xiang, J. Huguenard, D. Prince (1998)
Cholinergic switching within neocortical inhibitory networks.Science, 281 5379
J. Poncer, R. McKinney, B. Gähwiler, S. Thompson (1997)
Either N- or P-type Calcium Channels Mediate GABA Release at Distinct Hippocampal Inhibitory SynapsesNeuron, 18
B. Katz, R. Miledi (1968)
The role of calcium in neuromuscular facilitationThe Journal of Physiology, 195
Richard Lin, R. Scheller (1997)
Structural Organization of the Synaptic Exocytosis Core ComplexNeuron, 19
S. Thompson, B. Gahwiler (1989)
Activity-dependent disinhibition. II. Effects of extracellular potassium, furosemide, and membrane potential on ECl- in hippocampal CA3 neurons.Journal of neurophysiology, 61 3
L. Dobrunz, C. Stevens (1997)
Heterogeneity of Release Probability, Facilitation, and Depletion at Central SynapsesNeuron, 18
Francis Edwards, Arthur Konnerth, B. Sakmann (1990)
Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch‐clamp study.The Journal of Physiology, 430
I. Fleidervish, M. Gutnick (1995)
Paired-pulse facilitation of IPSCs in slices of immature and mature mouse somatosensory neocortex.Journal of neurophysiology, 73 6
R. Pearce, S Grunder, L Faucher (1995)
Different mechanisms for use‐dependent depression of two GABAA‐mediated IPSCs in rat hippocampus.The Journal of Physiology, 484
M. Andreasen, J. Hablitz (1994)
Paired-pulse facilitation in the dentate gyrus: a patch-clamp study in rat hippocampus in vitro.Journal of neurophysiology, 72 1
K. Yoon, S. Rothman (1991)
The modulation of rat hippocampal synaptic conductances by baclofen and gamma‐aminobutyric acid.The Journal of Physiology, 442
C. Stevens, Yanyan Wang (1995)
Facilitation and depression at single central synapsesNeuron, 14
B. Alger (1991)
Gating of GABAergic Inhibition in Hippocampal Pyramidal Cells aAnnals of the New York Academy of Sciences, 627
Christina Allen, Charles Stevens (1994)
An evaluation of causes for unreliability of synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America, 91 22
N. Spruston, D. Jaffe, Stephen Williams, D. Johnston (1993)
Voltage- and space-clamp errors associated with the measurement of electrotonically remote synaptic events.Journal of neurophysiology, 70 2
Mathew Jones, G. Westbrook (1995)
Desensitized states prolong GABAA channel responses to brief agonist pulsesNeuron, 15
D. Swandulla, M. Hans, K. Zipser, G. Augustine (1991)
Role of residual calcium in synaptic depression and posttetanic potentiation: Fast and slow calcium signaling in nerve terminalsNeuron, 7
M. Ouardouz, J. Lacaille (1997)
Properties of unitary IPSCs in hippocampal pyramidal cells originating from different types of interneurons in young rats.Journal of neurophysiology, 77 4
M. McCarren, B. Alger (1985)
Use-dependent depression of IPSPs in rat hippocampal pyramidal cells in vitro.Journal of neurophysiology, 53 2
C. Davies, G. Collingridge (1993)
The physiological regulation of synaptic inhibition by GABAB autoreceptors in rat hippocampus.The Journal of Physiology, 472
R. Khazipov, P. Congar, Y. Ben‐Ari (1995)
Hippocampal CA1 lacunosum-moleculare interneurons: modulation of monosynaptic GABAergic IPSCs by presynaptic GABAB receptors.Journal of neurophysiology, 74 5
M. Frerking, S. Borges, Martin Wilson (1995)
Variation in GABA mini amplitude is the consequence of variation in transmitter concentrationNeuron, 15
D. Debanne, N. Guérineau, B. Gähwiler, S. Thompson (1997)
Action-potential propagation gated by an axonal IA-like K+ conductance in hippocampusNature, 389
R. Miles, R. Wong (1984)
Unitary inhibitory synaptic potentials in the guinea‐pig hippocampus in vitro.The Journal of Physiology, 356
Charles Cox, J. Huguenard, David Prince (1997)
Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus.Proceedings of the National Academy of Sciences of the United States of America, 94 16
J. Castillo, B. Katz (1954)
Statistical factors involved in neuromuscular facilitation and depressionThe Journal of Physiology, 124
Jian Kang, Li Jiang, S. Goldman, M. Nedergaard (1998)
Astrocyte-mediated potentiation of inhibitory synaptic transmissionNature Neuroscience, 1
S. Thompson, B. Gähwiler (1989)
Activity-dependent disinhibition. I. Repetitive stimulation reduces IPSP driving force and conductance in the hippocampus in vitro.Journal of neurophysiology, 61 3
KS Wilcox, M. Dichter (1994)
Paired pulse depression in cultured hippocampal neurons is due to a presynaptic mechanism independent of GABAB autoreceptor activation, 14
M. Charlton, S. Smith, R. Zucker (1982)
Role of presynaptic calcium ions and channels in synaptic facilitation and depression at the squid giant synapse.The Journal of Physiology, 323
N. Lambert, W. Wilson (1994)
Temporally distinct mechanisms of use-dependent depression at inhibitory synapses in the rat hippocampus in vitro.Journal of neurophysiology, 72 1
I. Bezprozvanny, R. Scheller, R. Tsien (1995)
Functional impact of syntaxin on gating of N-type and Q-type calcium channelsNature, 378
Guy Major, A. Larkman, Peter Jonas, B. Sakmann, Julian Jack (1994)
Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices, 14
Christian Rosenmund, J. Clements, G. Westbrook (1993)
Nonuniform probability of glutamate release at a hippocampal synapse.Science, 262 5134
E. Buhl, K. Halasy, P. Somogyi (1994)
Diverse sources of hippocampal unitary inhibitory postsynaptic potentials and the number of synaptic release sitesNature, 368
C. Davies, S. Starkey, M. Pozza, G. Collingridge (1991)
GABAB autoreceptors regulate the induction of LTPNature, 349
Ping Li, T. Wilding, Susan Kim, A. Calejesan, J. Huettner, M. Zhuo (1999)
Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cordNature, 397
C. Davies, S. Davies, G. Collingridge (1990)
Paired‐pulse depression of monosynaptic GABA‐mediated inhibitory postsynaptic responses in rat hippocampus.The Journal of Physiology, 424
N. Hessler, A. Shirke, R. Malinow (1993)
The probability of transmitter release at a mammalian central synapseNature, 366
KE Sorra, KM Harris (1993)
Occurrence and three-dimensional structure of multiple synapses between individual radiatum axons and their target pyramidal cells in hippocampal area CA1, 13
P. Vincent, A. Marty (1996)
Fluctuations of inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices.The Journal of Physiology, 494
Matthew Hill, P. Reddy, D. Covey, S. Rothman (1998)
Contribution of Subsaturating GABA Concentrations to IPSCs in Cultured Hippocampal NeuronsThe Journal of Neuroscience, 18
Z. Nusser, S. Cull-Candy, M. Farrant (1997)
Differences in Synaptic GABAA Receptor Number Underlie Variation in GABA Mini AmplitudeNeuron, 19
D. Debanne, N. Guérineau, B. Gähwiler, S. Thompson (1996)
Paired‐pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release.The Journal of Physiology, 491
R. Deisz, D. Prince (1989)
Frequency‐dependent depression of inhibition in guinea‐pig neocortex in vitro by GABAB receptor feed‐back on GABA release.The Journal of Physiology, 412
David Mott, Cui-Wie Xie, Wilkie Wilson, H. Swartzwelder, Darrell Lewis (1993)
GABAB autoreceptors mediate activity-dependent disinhibition and enhance signal transmission in the dentate gyrus.Journal of neurophysiology, 69 3
1 Unitary inhibitory postsynaptic currents (uIPSCs) were recorded in synaptically coupled pairs of CA1 hippocampal interneurons and pyramidal neurons in rat brain slices by using dual patch‐clamp techniques. Paired‐pulse modulation of uIPSCs at individual GABAergic synapses was tested. 2 GABAergic synapses could be divided into two subgroups, high and low failure, depending on their failure rate. 3 The external Ca2+ levels modulate the failure rate of uIPSCs. In 0·51 mM Ca2+, low‐failure pairs had a high‐failure characteristic, whereas high‐failure pairs had a low‐failure characteristic in 8 mM Ca2+. The results suggest that uIPSC failures result from the Ca2+‐dependent release mechanism rather than axon propagation failures. 4 Paired‐pulse facilitation (PPF) occurred in high‐failure pairs when the interspike interval was 20 ms. Paired‐pulse depression (PPD) was not predominant in high‐failure pairs. 5 Potency of uIPSCs, the average amplitude of non‐failure events, was enhanced by PPF, suggesting that multiple synapses connect each pair. Differing numbers of activated synapses contributed to the variable amplitude of uIPSCs from a given pair. 6 PPD occurred in low‐failure pairs at the tested range of interspike intervals (20–200 ms). The uIPSC2 after a large uIPSC1 was smaller than the uIPSC2 after a small uIPSC1, suggesting that PPD is use dependent and due to a decrease in the quantal content (m) after the first release. 7 In 8 mM Ca2+, PPD occurred in high‐failure pairs and was larger in low‐failure pairs, suggesting that the occurrence of PPF or PPD depends on the baseline release probability. 8 The GABAB receptor antagonist CGP 55845A (5 μM) decreased the baseline release probability of inhibitory synapses and attenuated PPD indirectly, rather than by blocking presynaptic GABAB autoreceptors.
The Journal of Physiology – Wiley
Published: Mar 1, 2000
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.