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An integrated biotechnology platform for developing sustainable chemical processes

An integrated biotechnology platform for developing sustainable chemical processes Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Industrial Microbiology Biotechnology Springer Journals

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References (27)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Society for Industrial Microbiology and Biotechnology
Subject
Life Sciences; Microbiology; Biochemistry, general; Inorganic Chemistry; Genetic Engineering; Biotechnology; Bioinformatics
ISSN
1367-5435
eISSN
1476-5535
DOI
10.1007/s10295-014-1541-1
pmid
25416472
Publisher site
See Article on Publisher Site

Abstract

Genomatica has established an integrated computational/experimental metabolic engineering platform to design, create, and optimize novel high performance organisms and bioprocesses. Here we present our platform and its use to develop E. coli strains for production of the industrial chemical 1,4-butanediol (BDO) from sugars. A series of examples are given to demonstrate how a rational approach to strain engineering, including carefully designed diagnostic experiments, provided critical insights about pathway bottlenecks, byproducts, expression balancing, and commercial robustness, leading to a superior BDO production strain and process.

Journal

Journal of Industrial Microbiology BiotechnologySpringer Journals

Published: Nov 22, 2014

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