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What We Have Learned about Addiction from Animal Models of Drug Self‐Administration

What We Have Learned about Addiction from Animal Models of Drug Self‐Administration Self‐administration of addictive drugs in laboratory animals has been widely used for decades as a tool for studying behavioral, neurobiological, and genetic factors in addiction. From such studies has come an enormous amount of information on brain mechanisms involved in addiction, on vulnerability factors in the addictive process, and on possible pharmacotherapeutic treatments for addiction. Modifications of the laboratory animal self‐administration paradigmö including progressive ratio break‐point models and the “reinstatement” model of relapse to drug‐seeking behaviorö are currently increasing our knowledge of incentive motivational factors in addiction and of the mechanisms underlying relapse to drug self‐administration behavior. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The American Journal on Addictions Wiley

What We Have Learned about Addiction from Animal Models of Drug Self‐Administration

The American Journal on Addictions , Volume 9 (4) – Oct 1, 2000

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References (312)

Publisher
Wiley
Copyright
2000 American Academy of Addiction Psychiatry
ISSN
1055-0496
eISSN
1521-0391
DOI
10.1080/105504900750047355
Publisher site
See Article on Publisher Site

Abstract

Self‐administration of addictive drugs in laboratory animals has been widely used for decades as a tool for studying behavioral, neurobiological, and genetic factors in addiction. From such studies has come an enormous amount of information on brain mechanisms involved in addiction, on vulnerability factors in the addictive process, and on possible pharmacotherapeutic treatments for addiction. Modifications of the laboratory animal self‐administration paradigmö including progressive ratio break‐point models and the “reinstatement” model of relapse to drug‐seeking behaviorö are currently increasing our knowledge of incentive motivational factors in addiction and of the mechanisms underlying relapse to drug self‐administration behavior.

Journal

The American Journal on AddictionsWiley

Published: Oct 1, 2000

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