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S. Hagiwara, S. Miyazaki, N. Rosenthal (1976)
Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfishThe Journal of General Physiology, 67
M. Tachibana (1985)
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I. Engberg, J. Flatman, J. Lambert (1979)
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Ionic currents of solitary horizontal cells isolated from goldfish retina.The Journal of Physiology, 345
(1976)
Studies of an excitatory neurotransmitter: Synaptic and nonsynaptic
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The blocking effect ofL-glutamate on the anomalous rectifier K channels of solitary horizontal cells from Carassius auratus
L. Nowak, P. Bregestovski, P. Ascher, A. Herbet, A. Prochiantz (1984)
Magnesium gates glutamate-activated channels in mouse central neuronesNature, 307
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Mechanisms of post-synaptic
M. Kameyama, T. Kiyosue, M. Soejima (1983)
Single channel analysis of the inward rectifier K current in the rabbit ventricular cells.The Japanese journal of physiology, 33 6
Andrew Ishida, Akimichi KANEKOt, Masao Tachibana (1984)
Responses of solitary retinal horizontal cells from Carassius auratus to L‐glutamate and related amino acids.The Journal of Physiology, 348
H. Ohmori, S. Yoshida, S. Hagiwara (1981)
Single K+ channel currents of anomalous rectification in cultured rat myotubes.Proceedings of the National Academy of Sciences of the United States of America, 78 8
Y. Fukushima (1982)
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A. Shapovalov, B. Shiriaev, A. Velumian (1978)
Mechanisms of post‐synaptic excitation in amphibian motoneurones.The Journal of Physiology, 279
S. Hagiwara, S. Miyazaki, W. Moody, J. Patlak (1978)
Blocking effects of barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg.The Journal of Physiology, 279
(1976)
Studies of an excitatory neurotransmitter : Synaptic and nonsynaptic interactions Of L - glutamic acid
The effects of externally applied L‐glutamate (Glu) on K currents through the anomalous rectifier were studied in solitary horizontal cells dissociated from goldfish retinae under whole‐cell voltage‐clamp or cell‐attached patch‐clamp conditions using 'giga‐seal' suction pipettes. In the whole‐cell clamp experiments, hyperpolarization of the membrane below the resting potential (ca. ‐57 mV) induced a large voltage‐dependent inward current which has been identified as the K current through the anomalous rectifier (Ianomal.). Application of Glu to the external medium reduced Ianomal.. Reduction of the inward current was not seen in preparations in which Ianomal. has been blocked by an application of Cs or Ba ions to the external medium. Single‐channel currents through the anomalous rectifier were recorded under cell‐attached patch‐clamp conditions. The current showed an inward rectification; its amplitude increased with hyperpolarization of the patch membrane, and became below the noise level near the equilibrium potential of K ions (EK). No polarity reversal was observed even by a strong membrane depolarization. The patch membrane potential at which the current amplitude became undetectable shifted in parallel to the shift of EK. The open probability changed little with polarization of the patch membrane. When Glu (greater than 100 microM) was applied to the outside of the patch membrane, the number of available Ianomal. channels was decreased, but neither the single‐channel conductance, open or closed time constants, nor the open probability changed significantly. Removal of Glu produced the opposite sequence; i.e. the number of available Ianomal. channels increased with time. It was concluded that the reduction of the Glu‐induced current at hyperpolarized potentials in the whole‐cell recording configuration is due to the blocking action of Glu on Ianomal..
The Journal of Physiology – Wiley
Published: Jan 1, 1985
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