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resistance; signal transduction; calorimetry (HTG) is one of many metabolic conditions associated with abnormal carbohydrate metabolism (29). The abnormal carbohydrate metabolism of HTG is due in part to resistance is manifested by impaired -mediated glucose uptake (IMGU; see Refs. 23, 35, 36). To study HTG, the hyperemic euglycemic glucose clamp procedure performed in conjunction with a triglyceride emulsion infusion can be employed. This is an excellent experimental model that simulates endogenous HTG, particularly the underappreciated characteristic of acute postprial HTG commonly observed in patients with HTG (27). With this model, IMGU is reduced, -mediated suppression of plasma triglycerides free fatty acid (FFA) levels is counteracted, resulting in increased plasma triglyceride FFA levels that are comparable to endogenous HTG (2, 3, 23, 32, 35, 36). Moreover, high fasting plasma triglycerides correlate with fasting plasma FFA, suppression E424 0193-1849/96 $5.00 Copyright o 1996 of FFA, the reduction in IMGU (35, 36). These observations suggest that the coincident high plasma FFA associated with endogenous HTG mediate the effects of HTG implicate HTG high plasma FFA as underlying mechanisms of resistance. To explain FFA impairment of glucose metabolism, Rle et al. (28) proposed the glucose-fatty acid cycle hypothesis. They observed that, in
AJP - Endocrinology and Metabolism – The American Physiological Society
Published: Mar 1, 1996
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