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E. Snyder, A. Hezzey, Alfed Katz, Jay Bock (1981)
Occurrence of the Release Reaction during Preparation and Storage of Platelet ConcentratesVox Sanguinis, 41
E. Snyder, T. Koerner, R. Kakaiya, Patricia Moore, T. Kiraly (1983)
Effect of Mode of Agitation on Storage of Platelet Concentrates in PL‐732 Containers for 5 Days 1Vox Sanguinis, 44
E. Murphy, M. Francis, D. Bulling (1973)
Estimation of blood platelet survival—V. A method for the analysis of population dataJournal of Chronic Diseases, 26
Scott Murphy, Richard Kahn, Stein Holme, Gordon Phillips, William Sherwood, W. Davisson, D. Buchholz (1982)
Improved storage of platelets for transfusion in a new container.Blood, 60 1
Murphy Murphy, Francis Francis (1971)
The estimation of blood platelet survival. II. The multiple hit modelThromb Diath Haemorrh, 25
E. Murphy, M. Francis (1971)
The Estimation of Blood Platelet Survival II. The Multiple Hit ModelThrombosis and Haemostasis, 25
Staff Technologist Yale-New Haven Hospital
(1980)
Role of platelet-prostaglandin 1971
(1983)
Platelet storage at 22OC. Role of gas transport across plastic containers in maintenance
S. Murphy, S. Sayar, F. Gardner (1970)
Storage of Platelet Concentrates at 22°CBlood, 35
Associate Professor Cardiology
K. Schmidt, J. Rasmussen, A. Rasmussen, H. Arendrup (2009)
Comparative studies of the in vivo kinetics of simultaneously injected 111In- and 51Cr-labelled human platelets.Scandinavian journal of haematology, 30 5
T. Kunicki, M. Tuccelli, G. Becker, R. Aster (2003)
A Study of Variables Affecting the Quality of Platelets Stored at “Room Temperature”Transfusion, 15
T. Simon, E. Nelson, R. Carmen, S. Murphy (1983)
Extension of platelet concentrate storageTransfusion, 23
Murphy Murphy, Gardner Gardner (1975)
Platelet storage at 22°C. Role of gas transport across plastic containers in maintenance of viabilityBlood, 46
(1975)
Hemolysis in stored blood : stabilizing effect of phthalate plasticizer ( abstract )
Cell Labeling Laboratory, Veterans Administration Hospital
Stevens Stevens, Joist Joist, Surtera Surtera (1980)
Role of platelet‐prostaglandin synthesis in shear‐induced platelet alterationsBlood, 56
J. Fortynova, P. Kořínková, M. Vopatová (1988)
[Platelet concentrates].Casopis lekaru ceskych, 127 10
(1984)
Lack of conformity in the behavior of plateletsduring normal storageconditions at 22 OC
S. Murphy, S. Holme, E. Nelson, R. Carmen (1984)
Paired comparison of the in vivo and in vitro results of storage of platelet concentrates in two containersTransfusion, 24
U. Scheffel, Patricia McIntyre, B. Evatt, Dvornicky Ja, Natarajan Tk, Bolling Dr, E. Murphy (1977)
Evaluation of indium-111 as a new high photon yield gamma-emitting "physiological" platelet label.The Johns Hopkins medical journal, 140 6
E. Snyder, P. Ferri, E. Smith, M. Ezekowitz (1984)
Use of an electromechanical infusion pump for transfusion of platelet concentratesTransfusion, 24
Murphy Murphy, Simon Simon (1983)
Seven day storage of platelet concentrates in CLX thin film blood bags (abstract)Blood, 62
G. Grode, J. Miripol, J. Garber, T. Barber, D. Buchholz (1985)
Extended storage of platelets in a new plastic containerTransfusion, 25
Brown Rd, Leverett Lb, Lewis Cw, C. Alfrey, J. Hellums (1975)
Morphological, biochemical, and functional changes in human platelets subjected to shear stress.The Journal of laboratory and clinical medicine, 86 3
(1983)
bags ( abstract )
Robert Handin, N. Fortier, C. Valeri (1970)
Platelet Response to Hypotonic Stress after Storage at 4 C or 22 CTransfusion, 10
RB Bolin, BA Cheney, O. Simpliciano, CC Peck (1980)
In Vitro Evaluation of Platelets Stored in CPD‐Adenine FormulationsTransfusion, 20
T. Contreras, R. Sheibley, C. Valeri (1974)
Accumulation of DI‐2‐Ethylhexyl Phthalate (DEHP) in Whole Blood, Platelet Concentrates, and Platelet‐Poor PlasmaTransfusion, 14
U. Scheffel, M. Tsan, T. Mitchell, E. Camargo, H. Braine, M. Ezekowitz, E. Nickoloff, R. Hill-Zobel, E. Murphy, P. McIntyre (1982)
Human platelets labeled with In-111 8-hydroxyquinoline: kinetics, distribution, and estimates of radiation dose.Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 23 2
Snyder Snyder, Ezekowitz Ezekowitz, Aster Aster (1985)
Extended storage of platelets in a new plastic container. II. In vivo response to infusion of platelets stored 5 daysTransfusion, 25
Y. Ishikawa, Shigeru Sasakawa (1984)
Platelet Storage in Glow Discharge‐Treated Polyvinylchloride Bags: Effects of a Plasticizer on Platelet Hypotonic Shock ResponseVox Sanguinis, 47
E. Snyder, Michael Bookbinder, R. Kakaiya, P. Ferri, T. Kiraly (1983)
5‐Day Storage of Platelet Concentrates in CLX Containers: Effect of Type of AgitationVox Sanguinis, 45
K. Schmidt, J. Rasmussen, A. Rasmussen, H. Arendrup, M. Lorentzen (2009)
Comparative studies of the function and morphology of 111In- and 51Cr-labelled human platelets.Scandinavian journal of haematology, 31 1
W. Heaton, H. Davis, M. Welch, C. Mathias, J. Joist, L. Sherman, B. Siegel (1979)
Indium‐III: a New Radionuclide Label for Studying Human Platelet KineticsBritish Journal of Haematology, 42
Associate Blood Bank Director
Holme Holme, Vaidja Vaidja, Murphy Murphy (1978)
Platelet storage at 22°C: effect of type of agitation on morphology, viability and function in vitroBlood, 52
We studied the characteristics of platelet concentrates stored for 5 days at 22°C. Platelets were prepared in three plastic bags (PL 732, PL 1240, and CLX) and stored on one of four platelet agitators, 1‐ or 6‐rpm elliptical and 2‐ or 6‐rpm circular rotators. A total of 76 studies were divided among 12 groups, each group being composed of a different storage bagrotator combination. In vivo recovery and survival were calculated using Indium‐111 oxine‐labeled platelets injected into autologous volunteers. Platelet recovery was assessed at 2 hours postinjection or as the y‐intercept of the multiple‐hit model survival curve. Survival was calculated using linear, exponential, and multiple‐hit computer models. Linear T 1/2 also was calculated as an index of platelet survival. At 5 days, the pH of all concentrates was above pH 7.0 and platelet counts were above 5.5 × 1010 per bag except for the PL 732 with the 6‐rpm elliptical rotator, which was 4.6 × 1010 per bag. This combination also showed a significantly higher poststorage lactic dehydrogenase (LDH) discharge compared to the mean of the other 11 groups (23.6 ± 5.4% vs. 10.4 ± 3.0%, p < 0.05); however, the β‐thromboglobulin (β‐TG) release was not statistically different. The lowest in vivo recovery and survival T 1/2 were found for the PL 732 with the 6‐rpm elliptical rotator: 2‐hour recovery of 28.0 ± 3.2 percent vs. 40.0 ± 10.6 percent for the other 11 groups (p < 0.05) and survival T 1/2 of 2.1 ± 1.4 days vs. 2.9 ± 0.6 days (p<0.05). Survivals using the three computer models, however, were similar for all 12 groups and were 7.2 ± 1.3 days (linear), 3.3 ± 0.9 days (exponential), 5.7 ± 2.0 days (multiple hit) (n = 76). The percent in vitro release of β‐TG or discharge of LDH during storage did not predict in vivo recovery. We conclude that storage of platelet concentrates for 5 days in PL 732 containers on a 6‐rpm elliptical rotator is the least desirable method of storage; all other combinations gave acceptable and similar results.
Transfusion – Wiley
Published: Mar 4, 1986
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