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Serum protein binding and the role of increased alpha 1‐acid glycoprotein in moderately obese male subjects.

Serum protein binding and the role of increased alpha 1‐acid glycoprotein in moderately obese... Serum protein and lipid concentrations as well as the serum protein binding of propranolol, diazepam and phenytoin were measured in normal weight and obese volunteers. Concentrations of alpha 1‐acid glycoprotein (AAG) in the obese subjects were double that of the lean controls. Conversely, concentrations of high density lipoproteins (HDL) were decreased in the obese group. The serum binding of propranolol was increased in the obese subjects and correlated with serum AAG concentrations. Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentrations and elevated free fatty acids. The binding of phenytoin was comparable in all of the volunteers. These findings point out some of the complex pathophysiologic changes associated with obesity which may in turn influence drug disposition and hence drug therapy in the obese patient. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Clinical Pharmacology Wiley

Serum protein binding and the role of increased alpha 1‐acid glycoprotein in moderately obese male subjects.

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References (32)

Publisher
Wiley
Copyright
Copyright © 1984 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0306-5251
eISSN
1365-2125
DOI
10.1111/j.1365-2125.1984.tb02567.x
Publisher site
See Article on Publisher Site

Abstract

Serum protein and lipid concentrations as well as the serum protein binding of propranolol, diazepam and phenytoin were measured in normal weight and obese volunteers. Concentrations of alpha 1‐acid glycoprotein (AAG) in the obese subjects were double that of the lean controls. Conversely, concentrations of high density lipoproteins (HDL) were decreased in the obese group. The serum binding of propranolol was increased in the obese subjects and correlated with serum AAG concentrations. Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentrations and elevated free fatty acids. The binding of phenytoin was comparable in all of the volunteers. These findings point out some of the complex pathophysiologic changes associated with obesity which may in turn influence drug disposition and hence drug therapy in the obese patient.

Journal

British Journal of Clinical PharmacologyWiley

Published: Dec 1, 1984

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