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M. Lee, R. Harris, D. Green (1969)
Action of fluorescein mercuric acetate upon mitochondrial energized processes.Biochemical and biophysical research communications, 36 6
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
B. Chance, G. Williams (1955)
Respiratory enzymes in oxidative phosphorylation. III. The steady state.The Journal of biological chemistry, 217 1
R. Scott, J. Gamble (1961)
Effect of mercurial compounds on potassium binding by mitochondria.The Journal of biological chemistry, 236
Bertil Åberg, Lars Ekman, Rolf Falk, Ulf Greitz, Gunnar Persson, J. Snihs (1969)
Metabolism of methyl mercury (203Hg) compounds in man.Archives of environmental health, 19 4
H. Lardy, Diane Johnson, W. McMurray (1958)
Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems.Archives of biochemistry and biophysics, 78 2
Y. Yoshino, T. Mozai, K. Nakao (1966)
BIOCHEMICAL CHANGES IN THE BRAIN IN RATS POISONED WITH AN ALKYLMERCURY COMPOUND, WITH SPECIAL REFERENCE TO THE INHIBITION OF PROTEIN SYNTHESIS IN BRAIN CORTEX SLICESJournal of Neurochemistry, 13
S. Cooperstein, A. Lazarow (1951)
A microspectrophotometric method for the determination of cytochrome oxidase.The Journal of biological chemistry, 189 2
(1968)
Biochem . hiophys
F. Smith, H. Heintze (1970)
VOLUME CHANGES IN ELECTROLYTIC HYDROGEN EVOLUTION AT MERCURY IN AQUEOUS HYDROCHLORIC ACIDCanadian Journal of Chemistry, 48
P. Brubaker, R. Klein, S. Herman, G. Lucier, L. Alexander, M. Long (1973)
DNA, RNA, and protein synthesis in brain, liver, and kidneys of asymptomatic methylmercury treated rats.Experimental and molecular pathology, 18 3
M. Verity (1972)
CATION MODULATION OF SYNAPTOSOMAL RESPIRATIONJournal of Neurochemistry, 19
E. Harris, R. Cockrell, B. Pressman (1966)
Induced and spontaneous movements of potassium ions into mitochondria.The Biochemical journal, 99 1
K. Dam, C. Tsou (1968)
Accumulation of substrates by mitochondria.Biochimica et biophysica acta, 162 3
H. Krebs, L. Eggleston, C. Terner (1951)
In vitro measurements of the turnover rate of potassium in brain and retina.The Biochemical journal, 48 5
G. Brierley, C. Settlemire, V. Knight (1967)
Induction of K+ transport and swelling in isolated heart mitochondria by mercurial compounds.Biochemical and biophysical research communications, 28 3
J. Clark, W. Nicklas (1970)
The metabolism of rat brain mitochondria. Preparation and characterization.The Journal of biological chemistry, 245 18
K. Ozawa, K. Seta, H. Araki, H. Handa (1967)
The dependence of brain mitochondrial respiration on potassium ion.Journal of biochemistry, 61 3
D. Tyler (1969)
Evidence of a phosphate-transporter system in the inner membrane of isolated mitochondria.The Biochemical journal, 111 5
R. Bowman (1964)
Inhibition of citrate metabolism by sodium fluoroacetate in the perfused rat heart and the effect on phosphofructokinase activity and glucose utilization.The Biochemical journal, 93 2
(1971)
KumaExpert Group Report(b
E. Harris, J. Bangham, J. Wimhurst (1973)
The dependence on energy and K+ ions of the accumulation of glutamate by rat liver mitochondria.Archives of biochemistry and biophysics, 158 1
J. Southard, J. Penniston, D. Green (1973)
Induction of transmembrane proton transfer by mercurials in mitochondria. I. Ion movements accompanying transmembrane proton transfer.The Journal of biological chemistry, 248 10
J. Stern, L. Eggleston, R. Hems, H. Krebs (1949)
Accumulation of glutamic acid in isolated brain tissue.The Biochemical journal, 44 4
W. Nicklas, J. Clark, J. Williamson (1971)
Metabolism of rat brain mitochondria. Studies on the potassium ion-stimulated oxidation of pyruvate.The Biochemical journal, 123 1
I. Chang, P. Desnoyers, H. Hartmann (1972)
QUANTITATIVE CYTOCHEMICAL STUDIES OF RNA IN EXPERIMENTAL MERCURY POISONING. I. CHANGES IN RNA CONTENTJournal of Neuropathology and Experimental Neurology, 31
Y. Yoshino, T. Mozai, K. Nakao (1966)
DISTRIBUTION OF MERCURY IN THE BRAIN AND ITS SUBCELLULAR UNITS IN EXPERIMENTAL ORGANIC MERCURY POISONINGSJournal of Neurochemistry, 13
N. Nelson, T. Byerly, A. Kolbye, L. Kurland, R. Shapiro, S. Shibko, W. Stickel, J. Thompson, L. Berg, A. Weissler (1971)
Hazards of mercury. Special report to the secretary's pesticide aedvisory committee, Department of Health, Education, and Welfare, November 1970.Environmental research, 4 1
A. Galston (1970)
Chemical Fallout: Current Research on Persistent PesticidesThe Yale Journal of Biology and Medicine, 43
Berton Pressman, Henry Lardy (1955)
Further studies on the potassium requirements of mitochondria.Biochimica et biophysica acta, 18 4
—A reproducible model of subacute methyl mercury (MeHg) intoxication was developed in the adult rat following the daily intragastric administration of 10 mg methyl mercury/kg body wt. Synaptosomes isolated from animals during the latent phase of mercury neurotoxicity (6‐10 days) demonstrated no significant change in respiratory control, State 3, State 4, or 2,4‐dinitrophenol stimulated respiration with succinate, glutamate or pyruvate plus malate. During the neurotoxic phase, a significant decline in respiratory control was evident with all substrates. Cerebellar synaptosomes revealed qualitatively similar but quantitatively greater inhibition of 2,4‐dinitrophenol stimulated respiration during the latent and neurotoxic phases with glutamate. In vitro studies of synaptosome respiration, oxidative phosphorylation and respiratory control with 5‐15 μm‐methyl mercury revealed a stimulation of initial State 4 respiration, loss of RCI, inhibition of State 3 but no change in the gramicidin or 2,4‐dinitrophenol uncoupled rate supported by pyruvate‐malate. Phosphate did not relieve the State 3 inhibition. At 25 μm‐methyl mercury and above, considerable inhibition of electron transfer occurred. At this concentration, cytochrome c oxidase was inhibited 50%. Isosmotic replacement of medium KC1 by mannitol reduced the MeHg stimulation of State 4 respiration but had no effect on MeHg inhibition of ADP stimulated respiration. Half‐maximal stimulation of State 4 respiration by MeHg occurred at (K)+⋍ 6 mm. These findings are compatible with an energy‐linked methyl mercury induced cation translocation across the synaptosome (mitochondrial) membrane.
Journal of Neurochemistry – Wiley
Published: Dec 1, 1975
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