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Inv. I n pre& MICHAELIS, L. 1947
G. Scatchard, A. Batchelder, Alex Brown (1946)
Preparation and Properties of Serum and Plasma Proteins. VI. Osmotic Equilibria in Solutions of Serum Albumin and Sodium Chloride1,2,3Journal of the American Chemical Society, 68
R. Cannan, A. Kibrick, A. Palmer (1941)
THE AMPHOTERIC PROPERTIES OF EGG ALBUMINAnnals of the New York Academy of Sciences, 41
G. Scatchard
Mixed solutions of electrolytes and non-electrolytesTransactions of The Faraday Society, 23
F. Putnam, H. Neurath (1944)
STOICHIOMETRIC COMPLEXES OF SERUM ALBUMIN AND SODIUM DODECYL SULFATEJournal of the American Chemical Society, 66
F. Westheimer, J. Kirkwood (1938)
The Electrostatic Influence of Substituents on the Dissociation Constants of Organic Acids. IIJournal of Chemical Physics, 6
A. Muralt (1930)
THE TITRATION CONSTANTS OF MULTIVALENT SUBSTANCESJournal of the American Chemical Society, 52
(1930)
Physicd Organic Chemisstry
J. Steinhardt (1941)
PARTICIPATION OF ANIONS IN THE COMBINATION OF PROTEINS WITH ACIDSAnnals of the New York Academy of Sciences, 41
L. Michaelis (1947)
Ferritin and apoferritin.Advances in protein chemistry, 3
J. Kirkwood (1934)
Theory of Solutions of Molecules Containing Widely Separated Charges with Special Application to ZwitterionsJournal of Chemical Physics, 2
K. Pankhurst, R. Smith (1944)
The adsorption of paraffin-chain salts to proteins. Part I. Some factors influencing the formation and separation of complexes between gelatin and dodecyl sodium sulphateTransactions of The Faraday Society, 40
Klotz Im, Walker Fm, Pivan Rb (1946)
The Binding of Organic Ions by Proteins1Journal of the American Chemical Society, 68
Hughes Wl (1947)
An albumin fraction isolated from human plasma as a crystalline mercuric salt.Journal of the American Chemical Society, 69
K. McConnell (1948)
Passage of selenium through the mammary glands of the white rat and the distribution of selenium in the milk proteins after subcutaneous injection of sodium selenate.The Journal of biological chemistry, 173 2
The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story. For instance, there are the compounds of iron, which is carried in our blood plasma by a globulin, two atoms of iron to each molecule of globulin held in a rather tight salt-lie binding? which is stored as ferric hydroxide by ferritin much as water is held by a sponge? and which functions in hemoglobin, four iron atoms in tight porphyrin complexes in each protein molecule. Or, there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound. This molecule, which has about a hundred carboxyl radicals, each of which can take on a proton, and about the same number of ammonium radicals, each of which can dissociate a proton, has one single radical which combines with mercuric ion so firmly that two albumin molecules will share one mercury atom if there are not enough to go a r ~ u n d . ~ At the present stage of rapid growth of known compounds, it seems more profitable for me to make no
Annals of the New York Academy of Sciences – Wiley
Published: May 1, 1949
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