Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/transducing-hedgehog-the-story-so-far-f4vDCVH0VD
References (86)
-
M. Hynes, D. Stone, M. Dowd, S. Pitts-Meek, A. Goddard, A. Gurney, A. Rosenthal (1997)
Control of Cell Pattern in the Neural Tube by the Zinc Finger Transcription Factor and Oncogene Gli-1Neuron, 19
-
V. Palombella, O. Rando, A. Goldberg, T. Maniatis (1994)
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κBCell, 78
-
J. Ohlmeyer, D. Kalderon (1997)
Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos.Genes & development, 11 17
-
L. Goodrich, Ronald Johnson, Ljiljana Milenkovic, J. McMahon, M. Scott (1996)
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.Genes & development, 10 3
-
J. Quirk, M. Heuvel, D. Henrique, V. Marigo, T. Jones, C. Tabin, P. Ingham (1997)
The smoothened gene and hedgehog signal transduction in Drosophila and vertebrate development.Cold Spring Harbor symposia on quantitative biology, 62
-
T. Ohlen, D. Lessing, R. Nusse, J. Hooper (1997)
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein.Proceedings of the National Academy of Sciences of the United States of America, 94 6
-
J. Concordet, K. Lewis, John Moore, Lisa Goodrich, Ronald Johnson, Matthew Scott, Philip Ingham (1996)
Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning.Development, 122 9
-
Jin Jiang, G. Struhl (1998)
Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein SlimbNature, 391
-
Jingwu Xie, M. Murone, S. Luoh, A. Ryan, Q. Gu, Chaohui Zhang, J. Bonifas, C. Lam, M. Hynes, A. Goddard, A. Rosenthal, E. Epstein, F. Sauvage (1998)
Activating Smoothened mutations in sporadic basal-cell carcinomaNature, 391
-
D. Slusarski, V. Corces, R. Moon (1997)
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signallingNature, 390
-
H. Hahn, C. Wicking, P. Zaphiropoulos, M. Gailani, S. Shanley, A. Chidambaram, I. Vořechovský, E. Holmberg, A. Undén, Susan Gillies, K. Negus, I. Smyth, C. Pressman, D. Leffell, B. Gerrard, A. Goldstein, M. Dean, R. Toftgård, G. Chenevix-Trench, B. Wainwright, A. Bale (1996)
Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma SyndromeCell, 85
-
T. Préat (1992)
Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.Genetics, 132 3
-
P. Aza‐Blanc, F. Ramirez-Weber, M. Laget, Carol Schwartz, T. Kornberg (1997)
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a RepressorCell, 89
-
L. Goodrich, Ljiljana Milenkovic, K. Higgins, M. Scott (1997)
Altered neural cell fates and medulloblastoma in mouse patched mutants.Science, 277 5329
-
D. Stone, M. Hynes, M. Armanini, T. Swanson, Q. Gu, Ronald Johnson, M. Scott, D. Pennica, A. Goddard, H. Phillips, M. Noll, J. Hooper, F. Sauvage, A. Rosenthal (1996)
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehogNature, 384
-
C. Alexandre, A. Jacinto, P. Ingham (1996)
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.Genes & development, 10 16
-
J. Alcedo, M. Ayzenzon, T. Ohlen, M. Noll, J. Hooper (1996)
The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog SignalCell, 86
-
A. Arias, N. Baker, P. Ingham (1988)
Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo.Development, 103 1
-
P. Bhanot, M. Brink, C. Samos, J. Hsieh, Yanshu Wang, J. Macke, D. Andrew, J. Nathans, R. Nusse (1996)
A new member of the frizzled family from Drosophila functions as a Wingless receptorNature, 382
-
J. Sisson, Karen Ho, K. Suyama, M. Scott (1997)
Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling PathwayCell, 90
-
M. Heuvel, J. Klingensmith, J. Klingensmith, Norbert Perrimon, Roel Nusse (1993)
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.Development, 119 Suppl
-
D. Robbins, K. Nybakken, R. Kobayashi, J. Sisson, J. Bishop, P. Thérond (1997)
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2Cell, 90
-
Jerry Lee, S. Ekker, D. Kessler, J. Porter, B. Sun, P. Beachy (1994)
Autoproteolysis in hedgehog protein biogenesis.Science, 266 5190
-
J. Porter, D. Kessler, S. Ekker, K. Young, John Lee, K. Moses, P. Beachy (1995)
The product of hedgehog autoproteolytic cleavage active in local and long-range signallingNature, 374
-
Valeria Marigo, Randy Johnson, Andrea Vortkamp, Clifford Tabin (1996)
Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.Developmental biology, 180 1
-
J. Motoyama, T. Takabatake, K. Takeshima, C. Hui (1998)
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehogNature Genetics, 18
-
E. Sánchez-Herrero, J. Couso, J. Capdevila, I. Guerrero (1996)
The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discsMechanisms of Development, 55
-
Jeffrey Lee, K. Platt, P. Censullo, A. Altaba (1997)
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.Development, 124 13
-
D. Lessing, R. Nusse (1998)
Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression.Development, 125 8
-
Ronald Johnson, Alana Rothman, Jingwu Xie, L. Goodrich, J. Bare, J. Bonifas, A. Quinn, R. Myers, David Cox, E. Epstein, M. Scott (1996)
Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus SyndromeScience, 272
-
Philip Ingham, A. Taylor, Y. Nakano (1991)
Role of the Drosophila patched gene in positional signallingNature, 353
-
T. Takabatake, M. Ogawa, Tadashi Takahashi, M. Mizuno, M. Okamoto, K. Takeshima (1997)
Hedgehog and patched gene expression in adult ocular tissuesFEBS Letters, 410
-
Diane Slusarski, Cynthia Motzny, Robert Holmgren (1995)
Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster.Genetics, 139 1
-
T. Lepage, S. Cohen, F. Díaz-Benjumea, S. Parkhurst (1995)
Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterningNature, 373
-
H. Akimaru, Yang Chen, P. Dai, D. Hou, M. Nonaka, S. Smolik, Steve Armstrong, R. Goodman, S. Ishii (1997)
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signallingNature, 386
-
Venkatesh Krishnan, Fred Pereira, Y. Qiu, Chien-Huan Chen, P. Beachy, Sophia Tsai, Ming-Jer Tsai (1997)
Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase.Science, 278 5345
-
M van den Heuvel, PW Ingham (1996)
smoothened encodes a serpentine protein required for hedgehog signalingNature, 382
-
Yu Chen, G. Struhl (1996)
Dual Roles for Patched in Sequestering and Transducing HedgehogCell, 87
-
C. Wicking, S. Shanley, I. Smyth, Susan Gillies, K. Negus, Scott Graham, G. Suthers, N. Haites, M. Edwards, Brandon Wainwright, G. Chenevix-Trench (1997)
Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.American journal of human genetics, 60 1
-
Yang Chen, N. Gallaher, R. Goodman, S. Smolik (1998)
Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus.Proceedings of the National Academy of Sciences of the United States of America, 95 5
-
Y. Nakano, I. Guerrero, A. Hidalgo, A. Taylor, J. Whittle, P. Ingham (1989)
A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patchedNature, 341
-
J. Whittle (1976)
Clonal analysis of a genetically caused duplication of the anterior wing in Drosophila melanogaster.Developmental biology, 51 2
-
P. Ingham (1993)
Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryoNature, 366
-
P. Lawrence, B. Sanson, J. Vincent (1996)
Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos.Development, 122 12
-
A. Forbes, A. Spradling, P. Ingham, Haifan Lin (1996)
The role of segment polarity genes during early oogenesis in Drosophila.Development, 122 10
-
T. Ohlen, J. Hooper (1997)
Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancerMechanisms of Development, 68
-
I. Rodriguez, K. Basler (1997)
Control of compartmental affinity boundaries by HedgehogNature, 389
-
F. Díaz-Benjumea, B. Cohen, S. Cohen (1994)
Cell interaction between compartments establishes the proximal-distal axis of Drosophila legsNature, 372
-
J. Mohler (1988)
Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila.Genetics, 120 4
-
C. Nüsslein-Volhard, E. Wieschaus (1980)
Mutations affecting segment number and polarity in DrosophilaNature, 287
-
Chaoyong Ma, Ying Zhou, P. Beachy, K. Moses (1993)
The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eyeCell, 75
-
Alicia Hidalgo, Philip Ingham (1990)
Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched.Development, 110 1
-
A. Forbes, Y. Nakano, A. Taylor, Philip Ingham (1993)
Genetic analysis of hedgehog signalling in the Drosophila embryo.Development (Cambridge, England). Supplement
-
D. Bumcrot, R. Takada, Andandrew Mcmahon (1995)
Proteolytic processing yields two secreted forms of sonic hedgehogMolecular and Cellular Biology, 15
-
A. Chidambaram, A. Goldstein, M. Gailani, B. Gerrard, S. Bale, J. DiGiovanna, A. Bale, Michael Dean (1996)
Mutations in the human homologue of the Drosophila patched gene in Caucasian and African-American nevoid basal cell carcinoma syndrome patients.Cancer research, 56 20
-
T. Jensen, M. Loo, S. Pind, David Williams, A. Goldberg, J. Riordan (1995)
Multiple proteolytic systems, including the proteasome, contribute to CFTR processingCell, 83
-
M. Hammerschmidt, A. Brook, A. McMahon (1997)
The world according to bedgebogTrends in Genetics, 13
-
Valeria Marigo, Matthew Scott, Ronald Johnson, Lisa Goodrich, Clifford Tabin (1996)
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb.Development, 122 4
-
V. Marigo, R. Davey, Y. Zuo, James Cunningham, C. Tabin (1996)
Biochemical evidence that Patched is the Hedgehog receptorNature, 384
-
(1989)
The Drosophila segment polarity gene patched encodes a protein with multiple potential membrane spanning domains -
S. Blair, A. Ralston (1997)
Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila.Development, 124 20
-
Jennifer Hepker, Qun Wang, Cynthia Motzny, R. Holmgren, T. Orenic (1997)
Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes.Development, 124 2
-
T. Préat, P. Thérond, B. Limbourg-Bouchon, A. Pham, H. Tricoire, D. Busson, C. Lamour-Isnard (1993)
Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2.Genetics, 135 4
-
Cynthia Motzny, R. Holmgren (1995)
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathwaysMechanisms of Development, 52
-
Myriam Zecca, K. Basler, G. Struhl (1995)
Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing.Development, 121 8
-
J. Hooper, M. Scott (1989)
The Drosophila patched gene encodes a putative membrane protein required for segmental patterningCell, 59
-
J. Porter, S. Ekker, Woo-Jin Park, D. Kessler, K. Young, Chien-Huan Chen, Yong Ma, A. Woods, R. Cotter, E. Koonin, P. Beachy (1996)
Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing DomainCell, 86
-
M. Dominguez, Martina Brunner, E. Hafen, K. Basler (1996)
Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptusScience, 272
-
C. Hui, D. Slusarski, K. Platt, R. Holmgren, A. Joyner (1994)
Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.Developmental biology, 162 2
-
A. Bejsovec, E. Wieschaus (1993)
Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos.Development, 119 2
-
PW Ingham (1993)
Localised hedgehog activity controls spatially restricted transcription of wingless in the Drosophila embryoNature, 366
-
M. Heuvel, P. Ingham (1996)
smoothened encodes a receptor-like serpentine protein required for hedgehog signallingNature, 382
-
A. Borycki, Lori Mendham, C. Emerson (1998)
Control of somite patterning by Sonic hedgehog and its downstream signal response genes.Development, 125 4
-
M. Hammerschmidt, A. Brook, A. McMahon (1997)
The world according to hedgehog.Trends in genetics : TIG, 13 1
-
(1998)
Molecular interactions between three members of the Drosophila Hedgehog signalling pathway: Suppressor of fused links the ser-thr kinase Fused and the transcription factor Cubitus interruptus -
Willis Li, J. Ohlmeyer, M. Lane, D. Kalderon (1995)
Function of protein kinase A in hedgehog signal transduction and Drosophila imaginal disc developmentCell, 80
-
Jin Jiang, G. Struhl (1995)
Protein kinase A and hedgehog signaling in drosophila limb developmentCell, 80
-
J. Hooper (1994)
Distinct pathways for autocrine and paracrine Wingless signalling inDrosophila embryosNature, 372
-
David Strutt, Marek Mlodzik (1997)
Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc.Development, 124 17
-
Véronique Monnier, François Dussillol, G. Alves, C. Lamour-Isnard, A. Plessis (1998)
Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signalling pathwayCurrent Biology, 8
-
J Quirk, M van den Heuvel, D Henrique, V Marigo, T Jones, C Tabin, P Ingham (1997)
The smoothened gene and the anterior wing induction Drosophila and vertebrate developmentCold Spring Harbor Symp Quant Biol, 62
-
Y. Grau, P. Simpson (1987)
The segment polarity gene costal-2 in Drosophila. I. The organization of both primary and secondary embryonic fields may be affected.Developmental biology, 122 1
-
P. Ingham, A. Hidalgo (1993)
Regulation of wingless transcription in the Drosophila embryo.Development, 117 1
-
T. Orenic, D. Slusarski, K. Kroll, R. Holmgren (1990)
Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.Genes & development, 4 6
-
K. Basler, G. Struhl (1994)
Compartment boundaries and the control of Drosopfiffa limb pattern by hedgehog proteinNature, 368
-
J. Porter, K. Young, P. Beachy (1996)
Cholesterol Modification of Hedgehog Signaling Proteins in Animal DevelopmentScience, 274
- Publisher
- Wiley
- Copyright
- Copyright © 2013 Wiley Periodicals, Inc
- ISSN
- 0261-4189
- eISSN
- 1460-2075
- DOI
- 10.1093/emboj/17.13.3505
- pmid
- 9649421
- Publisher site
- See Article on Publisher Site
Abstract
The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.
Journal
The EMBO Journal – Wiley
Published: Jan 1, 1998
Keywords: ; ; ;