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This infomation is current as of December 29, 2010. AJP - Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. It is published 12 times a year (monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991. Copyright © 1997 by the American Physiological Society. ISSN: 0363-6143, ESSN: 1522-1563. Visit our website at http://www.the-aps.org/. YASUNOBU OKADA Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki 444, Japan Okada, Yasunobu. Volume expansion-sensing outward-rectifier Clchannel: fresh start to the molecular identity and volume sensor. Am. J. Physiol. 273 (CeZZ PhysioZ. 42): C755-C789,1997.-The maintenance of a constant volume in the face of extracellular and intracellular osmotic perturbation is essential for the normal function and survival of animal . Osmotically swollen restore their volume, exhibiting a regulatory volume decrease by releasing intracellular K+, Cl-, organic solutes, and obligated water. In many cell types, the volume regulatory effluxes of Cl- and some organic osmolytes are known to be induced by swellinginduced activation of anion channels that are characterized by their moderate outward rectification, cytosolic ATP dependency, and intermediate unitary conductance (lo-100 pS). Recently, simultaneous measurements of cell size by light microscopy and
AJP - Cell Physiology – The American Physiological Society
Published: Sep 1, 1997
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