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Delayed hypoperfusion in the cerebral cortex of the rat in the recovery period following severe hypoglycemia

Delayed hypoperfusion in the cerebral cortex of the rat in the recovery period following severe... Male Wistar rats were starved for 24 h before being injected with insulin (Novo Actrapid®) in a dose of 40 Iukg‐1 i.p. They were then anesthetized with 2–3% halothane, tracheotomized, immobilized with tubo‐curarine chloride (1.5 mg‐kg‐1, i.v.) and connected to a respirator delivering nitrous oxide‐oxygen (3:1). Femoral arterial catheters were inserted for blood pressure recording and blood sampling, and a femoral vein was cannulated for infusions. Goldplated screws were inserted in the skull bone for frontoparietal recording of EEG. Arterial PCO2was adjusted to 35–40 mmHg and body temperature was maintained close to 37oC. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Physiologica Wiley

Delayed hypoperfusion in the cerebral cortex of the rat in the recovery period following severe hypoglycemia

Acta Physiologica , Volume 106 (3) – Jul 1, 1979

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References (7)

Publisher
Wiley
Copyright
Copyright © 1979 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1748-1708
eISSN
1748-1716
DOI
10.1111/j.1748-1716.1979.tb06413.x
pmid
506773
Publisher site
See Article on Publisher Site

Abstract

Male Wistar rats were starved for 24 h before being injected with insulin (Novo Actrapid®) in a dose of 40 Iukg‐1 i.p. They were then anesthetized with 2–3% halothane, tracheotomized, immobilized with tubo‐curarine chloride (1.5 mg‐kg‐1, i.v.) and connected to a respirator delivering nitrous oxide‐oxygen (3:1). Femoral arterial catheters were inserted for blood pressure recording and blood sampling, and a femoral vein was cannulated for infusions. Goldplated screws were inserted in the skull bone for frontoparietal recording of EEG. Arterial PCO2was adjusted to 35–40 mmHg and body temperature was maintained close to 37oC.

Journal

Acta PhysiologicaWiley

Published: Jul 1, 1979

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