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Kazuaki Tejima, M. Arai, H. Ikeda, T. Tomiya, M. Yanase, Y. Inoue, K. Nagashima, Takako Nishikawa, N. Watanabe, M. Omata, K. Fujiwara (2004)
Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats.Gastroenterology, 127 5
M. Arai, R. Thurman, J. Lemasters (2000)
Contribution of adenosine A2 receptors and cyclic adenosine monophosphate to protective ischemic preconditioning of sinusoidal endothelial cells against storage/reperfusion injury in rat liversHepatology, 32
A. Abdulkarim, L. Petrovic, W. Kim, P. Angulo, R. Lloyd, K. Lindor (2002)
Primary biliary cirrhosis: an infectious disease caused by Chlamydia pneumoniae?Journal of hepatology, 40 3
M. Arai, R. Thurman, J. Lemasters (2001)
Ischemic preconditioning of rat livers against cold storage‐reperfusion injury: Role of nonparenchymal cells and the phenomenon of heterologous preconditioningLiver Transplantation, 7
M. Arai, Kazuaki Tejima, H. Ikeda, T. Tomiya, M. Yanase, Y. Inoue, K. Nagashima, M. Omata, K. Fujiwara (2003)
661 Ischemic preconditioning promotes liver regeneration after partial hepatectomy by stimulation of adenosine A2 receptor pathwayHepatology, 38
(2004)
Promotion of liver regeneration by ischemic preconditioning is mediated by stimulation of adenosine A2 receptors on Kupffer cells
Arai Arai, Tejima Tejima, Ikeda Ikeda (2002)
Ischemic preconditioning promotes liver regeneration after partial hepatectomyHepatology, 36
Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia–reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Ischemic preconditioning decreased liver injury after warm ischemia–reperfusion, which was reversed by Kupffer cell depletion. Ischemic preconditioning stimulated Kupffer cells to produce reactive oxygen species. Scavengers of reactive oxygen species reversed the effect of ischemic preconditioning, and pretreatment with sublethal dose of hydrogen peroxide mimicked ischemic preconditioning effect. Rat livers were preconditioned by ischemia and subjected to 70% partial hepatectomy. Liver regeneration was then evaluated serially. Ischemic preconditioning promoted liver regeneration, which was reversed by adenosine A2 receptor antagonism and mimicked by adenosine A2 receptor agonism. Promotion of liver regeneration by ischemic preconditioning and adenosine A2 receptor agonism were reversed by Kupffer cell depletion. In conclusion, ischemic preconditioning stimulates Kupffer cells to produce reactive oxygen species, leading to hepatocyte protection against warm ischemia–reperfusion injury; and ischemic preconditioning promoted liver regeneration via adenosine A2 receptor pathway in Kupffer cells.
Journal of Gastroenterology and Hepatology – Wiley
Published: Jun 1, 2007
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