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Serotonergic sprouting in primate MTP-induced hemiparkinsonism

Serotonergic sprouting in primate MTP-induced hemiparkinsonism 221 96 96 1 1 P. Gaspar A. Febvret J. Colombo INSERM U106, Hopital Salpêtrière F-75651 Paris Cedex 13 France Programa Unidad de Neurobiologia Aplicada (PRUNA) Avenida Galvan 4102 1431 Buenos Aires Argentina Abstract Immunocytochemistry to serotonin, dopamine beta hydroxylase (DBH), and tyrosine hydroxylase (TH) was studied in the brains of 2 cebus monkeys that had developed permanent hemiparkinsonism after intracarotid injection of 1.2 mg N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and were sacrificed after 10–12 months. A pronounced depletion of TH-immunoreactive neurons was found in the substantia nigra, caudate nucleus, and putamen, ipsilaterally to the injected side. In these dopamine-denervated structures, the number of serotonergic fibers was increased in the ipsilateral compared with the contralateral side, or with an untreated control monkey. Serotonergic neurons in the brainstem appeared to be unaffected. Topography and number of DBH-positive fibers in the control and the MPTP-injected sides were comparable. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Serotonergic sprouting in primate MTP-induced hemiparkinsonism

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References (34)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00230443
Publisher site
See Article on Publisher Site

Abstract

221 96 96 1 1 P. Gaspar A. Febvret J. Colombo INSERM U106, Hopital Salpêtrière F-75651 Paris Cedex 13 France Programa Unidad de Neurobiologia Aplicada (PRUNA) Avenida Galvan 4102 1431 Buenos Aires Argentina Abstract Immunocytochemistry to serotonin, dopamine beta hydroxylase (DBH), and tyrosine hydroxylase (TH) was studied in the brains of 2 cebus monkeys that had developed permanent hemiparkinsonism after intracarotid injection of 1.2 mg N -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and were sacrificed after 10–12 months. A pronounced depletion of TH-immunoreactive neurons was found in the substantia nigra, caudate nucleus, and putamen, ipsilaterally to the injected side. In these dopamine-denervated structures, the number of serotonergic fibers was increased in the ipsilateral compared with the contralateral side, or with an untreated control monkey. Serotonergic neurons in the brainstem appeared to be unaffected. Topography and number of DBH-positive fibers in the control and the MPTP-injected sides were comparable.

Journal

Experimental Brain ResearchSpringer Journals

Published: Sep 1, 1983

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