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László Offertáler, F. Mo, S. Batkai, Jie Liu, M. Begg, R. Razdan, B. Martin, R. Bukoski, G. Kunos (2003)
Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor.Molecular pharmacology, 63 3
David Harris, A. Mcculloch, D. Kendall, M. Randall (2002)
Characterization of vasorelaxant responses to anandamide in the rat mesenteric arterial bedThe Journal of Physiology, 539
(2000)
Vanilloid receptors on
Richard White, W. Ho, F. Bottrill, W. Ford, C. Hiley (2001)
Mechanisms of anandamide‐induced vasorelaxation in rat isolated coronary arteriesBritish Journal of Pharmacology, 134
S. O’Sullivan, D. Kendall, M. Randall (2004)
Characterisation of the vasorelaxant properties of the novel endocannabinoid N‐arachidonoyl‐dopamine (NADA)British Journal of Pharmacology, 141
(2003)
G proteincoupled endothelial receptor for atypical cannabinoid ligands modulates
J. Grainger, G. Boachie-Ansah (2001)
Anandamide‐induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channelsBritish Journal of Pharmacology, 134
Z. Járai, J. Wagner, J. Wagner, K. Varga, K. Lake, D. Compton, B. Martin, A. Zimmer, T. Bonner, N. Buckley, É. Mezey, R. Razdan, A. Zimmer, G. Kunos (1999)
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.Proceedings of the National Academy of Sciences of the United States of America, 96 24
W. Ho, C. Hiley (2003)
Endothelium‐independent relaxation to cannabinoids in rat‐isolated mesenteric artery and role of Ca2+ influxBritish Journal of Pharmacology, 139
D. Andersson, M. Adner, E. Högestätt, P. Zygmunt (2002)
Mechanisms underlying tissue selectivity of anandamide and other vanilloid receptor agonists.Molecular pharmacology, 62 3
A. Chaytor, P. Martin, W. Evans, M. Randall, T. Griffith (1999)
The endothelial component of cannabinoid‐induced relaxation in rabbit mesenteric artery depends on gap junctional communicationThe Journal of Physiology, 520
M. Mulvany, W. Halpern (1977)
Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats.Circulation research, 41 1
(1997)
Studies on the effects
P. Tep-areenan, D. Kendall, M. Randall (2003)
Mechanisms of vasorelaxation to testosterone in the rat aorta.European journal of pharmacology, 465 1-2
Z. Járai, G. Kunos (2002)
[Cardiovascular effects of cannabinoids].Orvosi hetilap, 143 26
S. Mukhopadhyay, B. Chapnick, A. Howlett (2002)
Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent.American journal of physiology. Heart and circulatory physiology, 282 6
Richard White, C. Hiley (1997)
A comparison of EDHF‐mediated and anandamide‐induced relaxations in the rat isolated mesenteric arteryBritish Journal of Pharmacology, 122
W. Ford, S. Honan, Richard White, C. Hiley (2002)
Evidence of a novel site mediating anandamide‐induced negative inotropic and coronary vasodilatator responses in rat isolated heartsBritish Journal of Pharmacology, 135
A. Mcculloch, F. Bottrill, M. Randall, C. Hiley (1997)
Characterization and modulation of EDHF‐mediated relaxations in the rat isolated superior mesenteric arterial bedBritish Journal of Pharmacology, 120
(1996)
An endogenous cannabinoid
M. Begg, F. Mo, László Offertáler, S. Batkai, P. Pacher, R. Razdan, D. Lovinger, G. Kunos (2003)
G Protein-coupled Endothelial Receptor for Atypical Cannabinoid Ligands Modulates a Ca2+-dependent K+ Current*Journal of Biological Chemistry, 278
P. Zygmunt, J. Petersson, D. Andersson, H. Chuang, M. Sørgård, V. Marzo, D. Julius, E. Högestätt (1999)
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamideNature, 400
M. Rinaldi-Carmona, Françoise Pialot, C. Congy, Elsa Redon, Francis Barth, A. Bachy, J. Breliere, Philippe Soubrié, G. Fur (1996)
Characterization and distribution of binding sites for [3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain.Life sciences, 58 15
P. Zygmunt, E. Högestätt, K. Waldeck, G. Edwards, A. Kirkup, A. Weston (1997)
Studies on the effects of anandamide in rat hepatic arteryBritish Journal of Pharmacology, 122
M. Randall, T. Griffith (1991)
Differential effects of l‐arginine on the inhibition by NG‐nitro‐l‐arginine methyl ester of basal and agonist‐stimulated EDRF activityBritish Journal of Pharmacology, 104
J. Wagner, K. Varga, Z. Járai, G. Kunos (1999)
Mesenteric vasodilation mediated by endothelial anandamide receptors.Hypertension, 33 1 Pt 2
(1998)
Cannabinoid (CB1) receptor expression is associated with mesenteric resistance vessels but not thoracic aorta in the rat
RANDALL (2002)
Cardiovascular effects of cannabinoidsPharm. Ther., 95
M. Randall, Stephen Alexander, T. Bennett, E. Boyd, J. Fry, S. Gardiner, P. Kemp, A. Mcculloch, D. Kendall (1996)
An endogenous cannabinoid as an endothelium-derived vasorelaxant.Biochemical and biophysical research communications, 229 1
V. Ralevic, D. Kendall, M. Randall, P. Zygmunt, P. Movahed, E. Högestätt (2000)
Vanilloid receptors on capsaicin‐sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteriesBritish Journal of Pharmacology, 130
L. Petrocellis, T. Bisogno, M. Maccarrone, John Davis, A. Finazzi-Agrò, V. Marzo (2001)
The Activity of Anandamide at Vanilloid VR1 Receptors Requires Facilitated Transport across the Cell Membrane and Is Limited by Intracellular Metabolism*The Journal of Biological Chemistry, 276
Michael Randall, David Kendall (1998)
Anandamide and endothelium-derived hyperpolarizing factor act via a common vasorelaxant mechanism in rat mesentery.European journal of pharmacology, 346 1
Dale Deutsch, M. Goligorsky, P. Schmid, R. Krebsbach, H. Schmid, Sanjoy Das, Sudhansu Dey, Gladys Arreaza, C. Thorup, George Stefano, L. Moore (1997)
Production and physiological actions of anandamide in the vasculature of the rat kidney.The Journal of clinical investigation, 100 6
Bert Vanheel, J. Voorde (2001)
Regional differences in anandamide- and methanandamide-induced membrane potential changes in rat mesenteric arteries.The Journal of pharmacology and experimental therapeutics, 296 2
In order to address mechanistic differences between arterial vessel types, we have compared the vasorelaxant actions of anandamide in resistance (G3) and conduit (G0) mesenteric arteries. Anandamide produced concentration‐dependent relaxations of pre‐constricted G3 arteries with a maximal response that was significantly greater than seen in G0. The CB1 receptor selective antagonists SR141716A (100 nM) and AM251 (100 nM) caused reductions in the vasorelaxant responses to anandamide in both arteries. Maximal vasorelaxant responses to anandamide were reduced in both arteries after treatment with capsaicin to deplete sensory neurotransmitters (10 μM for 1 h). Vasorelaxation to anandamide was not affected by the nitric oxide synthase inhibitor NG‐nitro‐L‐arginine methyl ester (L‐NAME, 300 μM) in either artery. Only responses in G3 arteries were sensitive to removal of the endothelium. In G3 vessels only, vasorelaxation to anandamide was reduced by inhibition of EDHF activity with a combination of charybdotoxin (100 nM) and apamin (500 nM) in the presence of L‐NAME (300 μM) and indomethacin (10 μM). Antagonism of the novel endothelial cannabinoid receptor (O‐1918, 1 μM) caused a reduction in the sensitivity to anandamide in G3 but not G0. G3, but not G0, vessels showed a small reduction in vasorelaxant responses to anandamide after inhibition of gap junctional communication with 18α‐GA (100 μM). These results demonstrate that there are differences in the mechanisms of vasorelaxation to anandamide between conduit and resistance mesenteric arteries. In small resistance vessels, vasorelaxation occurs through stimulation of vanilloid receptors, CB1 receptors, and an endothelial receptor coupled to EDHF release. By contrast, in the larger mesenteric artery, vasorelaxation is almost entirely due to stimulation of vanilloid receptors and CB1 receptors, and is endothelium‐independent. British Journal of Pharmacology (2004) 142, 435–442. doi:10.1038/sj.bjp.0705810
British Journal of Pharmacology – Wiley
Published: Jun 1, 2004
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