Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Roberts, G. D'Urso (1988)
An origin unwinding activity regulates initiation of DNA replication during mammalian cell cycle.Science, 241 4872
Anindya Dutta, B. Stillman (1992)
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.The EMBO Journal, 11
J. Brown, S. Holmes, M. Smith (1991)
The chromatin structure of Saccharomyces cerevisiae autonomously replicating sequences changes during the cell division cycleMolecular and Cellular Biology, 11
X. Hua, Hong Yan, J. Newport (1997)
A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell CycleThe Journal of Cell Biology, 137
Mary Hendrickson, M. Madine, Stephen Dalton, Jean Gautier (1996)
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.Proceedings of the National Academy of Sciences of the United States of America, 93 22
P. Thömmes, R. Fett, B. Schray, R. Burkhart, M. Barnes, C. Kennedy, N. Brown, R. Knippers (1992)
Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein.Nucleic acids research, 20 5
D. Wolf, Duan Wu, F. McKeon (1996)
Disruption of Re-replication Control by Overexpression of Human ORC1 in Fission Yeast*The Journal of Biological Chemistry, 271
Beáta Grallert, Paul Nurse (1996)
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.Genes & development, 10 20
T. Krude, M. Jackman, J. Pines, R. Laskey (1997)
Cyclin/Cdk-Dependent Initiation of DNA Replication in a Human Cell-Free SystemCell, 88
P. Dijkwel, J. Hamlin (1996)
Sequence and context effects on origin function in mammalian cellsJournal of Cellular Biochemistry, 62
E. Hogan, D. Koshland (1992)
Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America, 89 7
D. Broek, Rachel Bartlett, K. Crawford, P. Nurse (1991)
Involvement of p34cdc2 in establishing the dependency of S phase on mitosisNature, 349
S. Bell, Y. Marahrens, H. Rao, B. Stillman (1993)
The replicon model and eukaryotic chromosomes.Cold Spring Harbor symposia on quantitative biology, 58
S. Bell, Jay Mitchell, Jess Leber, R. Kobayashi, B. Stillman (1995)
The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencingCell, 83
Y. Marahrens, B. Stillman (1994)
Replicator dominance in a eukaryotic chromosome.The EMBO Journal, 13
M. Meyerson, G. Enders, Chin-Lee Wu, L. Su, C. Gorka, C. Nelson, E. Harlow, L. Tsai (1992)
A family of human cdc2‐related protein kinases.The EMBO Journal, 11
Peter Jackson, Michel ippe, Marc Kirschner (1995)
Early events in DNA replication require cyclin E and are blocked by p21CIP1The Journal of Cell Biology, 130
M. Fujita, T. Kiyono, Y. Hayashi, M. Ishibashi (1996)
Inhibition of S-phase entry of human fibroblasts by an antisense oligomer against hCDC47.Biochemical and biophysical research communications, 219 2
Stephen Dalton, L. Whitbread (1995)
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.Proceedings of the National Academy of Sciences of the United States of America, 92
S. Elledge (1996)
Cell Cycle Checkpoints: Preventing an Identity CrisisScience, 274
A. Rowles, J. Chong, L. Brown, M. Howell, G. Evan, J. Blow (1996)
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin XenopusCell, 87
E. Schwob, K. Nasmyth (1993)
CLB5 and CLB6, a new pair of B cyclins involved in DNA replication in Saccharomyces cerevisiae.Genes & development, 7 7A
M. Muzi-Falconi, G. Brown, T. Kelly (1996)
cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe.Proceedings of the National Academy of Sciences of the United States of America, 93 4
Kohta Takahashi, Hiroshi Yamada, M. Yanagida (1994)
Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality.Molecular biology of the cell, 5 10
S. Miyake, I. Saito, H. Kobayashi, S. Yamashita (1996)
Identification of two Xenopus laevis genes, xMCM2 and xCDC46, with sequence homology to MCM genes involved in DNA replication.Gene, 175 1-2
B. Schneider, Q.-H. Yang, A. Futcher (1996)
Linkage of Replication to Start by the Cdk Inhibitor Sic1Science, 272
Kevin Hennessy, C. Clark, D. Botstein (1990)
Subcellular localization of yeast CDC46 varies with the cell cycle.Genes & development, 4 12B
A. Jackson, P. Pahl, '. Harrison, J. Rosamond, '. ROBERTA.SCLAFANI (1993)
Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 proteinMolecular and Cellular Biology, 13
R. Williams, R. Shohet, B. Stillman (1997)
A human protein related to yeast Cdc6p.Proceedings of the National Academy of Sciences of the United States of America, 94 1
Akio Sugino (1995)
Yeast DNA polymerases and their role at the replication fork.Trends in biochemical sciences, 20 8
J. Pines (1994)
Protein kinases and cell cycle control.Seminars in cell biology, 5 6
L. Whitbread, S. Dalton (1995)
Cdc54 belongs to the Cdc46/Mcm3 family of proteins which are essential for initiation of eukaryotic DNA replication.Gene, 155 1
N. Takizawa, H. Kimura, K. Sugimoto (1995)
Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system.Gene, 167 1-2
K. Onel, W. Holloman (1997)
Molecular cloning of a gene required for DNA replication in Ustilago maydisMolecular and General Genetics MGG, 253
L. Hartwell, J. Culotti, J. Pringle, B. Reid (1974)
Genetic control of the cell division cycle in yeast.Science, 183 4120
R. King, R. Deshaies, J. Peters, M. Kirschner (1996)
How Proteolysis Drives the Cell CycleScience, 274
J. Diffley, Julie Cocker (1992)
Protein-DNA interactions at a yeast replication originNature, 357
Hong Yan, Susan Gibson, Susan Gibson, B. Tye (1991)
Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.Genes & development, 5 6
P. Donohue, G. Alberts, Yan Guo, J. Winkles (1995)
Identification by Targeted Differential Display of an Immediate Early Gene Encoding a Putative Serine/Threonine Kinase(*)The Journal of Biological Chemistry, 270
C. Hardy, A. Pautz (1996)
A novel role for Cdc5p in DNA replicationMolecular and Cellular Biology, 16
J. Blow, R. Laskey (1988)
A role for the nuclear envelope in controlling DNA replication within the cell cycleNature, 332
B. Fenton, D. Glover (1993)
A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryosNature, 363
J. Treisman, P. Follette, P. O’Farrell, G. Rubin (1995)
Cell proliferation and DNA replication defects in a Drosophila MCM2 mutant.Genes & development, 9 14
K. Takahara, M. Bong, R. Brevard, R. Eddy, L. Haley, S. Sait, T. Shows, G. Hoffman, D. Greenspan (1996)
Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.Genomics, 31 1
S. Gibson, R. Surosky, B. Tye (1990)
The phenotype of the minichromosome maintenance mutant mcm3 is characteristic of mutants defective in DNA replicationMolecular and Cellular Biology, 10
Eugene Kroll, K. Hyland, P. Hieter, Joachim Li (1996)
Establishing genetic interactions by a synthetic dosage lethality phenotype.Genetics, 143 1
C. Hardy, Olga Dryga, Sara Seematter, P. Pahl, R. Sclafani (1997)
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p.Proceedings of the National Academy of Sciences of the United States of America, 94 7
P. Romanowski, M. Madine, R. Laskey (1996)
XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication.Proceedings of the National Academy of Sciences of the United States of America, 93 19
P. Carpenter, P. Mueller, W. Dunphy (1996)
Role for a Xenopus Orc2-related protein in controlling DNA replicationNature, 379
Werner Zwerschke, H. Rottjakob, Hans KuntzelS (1994)
The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation.The Journal of biological chemistry, 269 37
D. Moir, S. Stewart, B. Osmond, D. Botstein (1982)
Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties, and pseudoreversion studies.Genetics, 100 4
S. Bell, R. Kobayashi, B. Stillman (1993)
Yeast origin recognition complex functions in transcription silencing and DNA replication.Science, 262 5141
Y. Kubota, S. Mimura, Shin-ichi Nishimoto, H. Takisawa, H. Nojima (1995)
Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factorCell, 81
Y. Marahrens, Y. Marahrens, B. Stillman, B. Stillman (1992)
A yeast chromosomal origin of DNA replication defined by multiple functional elements.Science, 255 5046
H. Mahbubani, James Chong, S. Chevalier, P. Thömmes, J. Blow (1997)
Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent InhibitorThe Journal of Cell Biology, 136
Junjie Chen, P. Jackson, M. Kirschner, Anindya Dutta (1995)
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNANature, 374
H. Rao, Y. Marahrens, Bruce Stillman (1994)
Functional conservation of multiple elements in yeast chromosomal replicatorsMolecular and Cellular Biology, 14
J. Wan, H. Xu, M. Grunstein (1992)
CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle.The Journal of biological chemistry, 267 16
T. Maclachlan, N. Sang, A. Giordano (1995)
Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer.Critical reviews in eukaryotic gene expression, 5 2
M. Fujita, T. Kiyono, Y. Hayashi, M. Ishibashi (1996)
hCDC47, a Human Member of the MCM FamilyThe Journal of Biological Chemistry, 271
Domenico Maiorano, Greet Assendelft, S. Kearsey (1996)
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.The EMBO Journal, 15
M. Patterson, R. Sclafani, W. Fangman, J. Rosamond (1986)
Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiaeMolecular and Cellular Biology, 6
C. Harvey, Yangxi Wang, D. Darmoul, A. Phillips, N. Mantei, D. Swallow (1996)
Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21FEBS Letters, 398
S. Bell (1995)
Eukaryotic replicators and associated protein complexes.Current opinion in genetics & development, 5 2
T. Fletcher, Jeffrey Hansen (1996)
The nucleosomal array: structure/function relationships.Critical reviews in eukaryotic gene expression, 6 2-3
C. Musahl, D. Schulte, Roland Burkhart, R. Knippers (1995)
A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.European journal of biochemistry, 230 3
Kimberley Gavin, M. Hidaka, B. Stillman (1995)
Conserved Initiator Proteins in EukaryotesScience, 270
Catherine Fox, Jasper Rine (1996)
Influences of the cell cycle on silencing.Current opinion in cell biology, 8 3
M. Mendenhall (1993)
An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae.Science, 259 5092
Ming Lei, Yasuo Kawasaki, B. Tye (1996)
Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiaeMolecular and Cellular Biology, 16
I. Todorov, R. Pepperkok, R. Philipova, S. Kearsey, W. Ansorge, D. Werner (1994)
A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division.Journal of cell science, 107 ( Pt 1)
M. Gossen, Daniel Pak, S. Hansen, J. Acharya, M. Botchan (1995)
A Drosophila Homolog of the Yeast Origin Recognition ComplexScience, 270
Marco Muzi-Falconi, Thomas Kelly (1995)
Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex.Proceedings of the National Academy of Sciences of the United States of America, 92 26
J. Chong, H. Mahbubani, Chong-Yee Khoo, J. Blow (1995)
Purification of an MCM-containing complex as a component of the DNA replication licensing systemNature, 375
E. Koonin (1993)
A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.Nucleic acids research, 21 11
H. Yoon, J. Campbell (1991)
The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity.Proceedings of the National Academy of Sciences of the United States of America, 88
S. Forsburg, P. Nurse (1994)
The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins.Journal of cell science, 107 ( Pt 10)
E. Schwob, T. Böhm, M. Mendenhall, K. Nasmyth (1994)
The B-type cyclin kinase inhibitor p40 SIC1 controls the G1 to S transition in S. cerevisiaeCell, 79
Gregory Maine, Pratima Sinha, B. Tye (1984)
Mutants of S. cerevisiae defective in the maintenance of minichromosomes.Genetics, 106 3
H. Kimura, N. Takizawa, N. Nozaki, K. Sugimoto (1995)
Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins.Nucleic acids research, 23 12
H. Nasheuer, A. Moore, A. Wahl, T. Wang (1991)
Cell cycle-dependent phosphorylation of human DNA polymerase alpha.The Journal of biological chemistry, 266 12
P. Jallepalli, Thomas Kelly (1996)
Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharomyces pombe.Genes & development, 10 5
G. Feger, H. Vaessin, T. Su, Erica Wolff, L. Jan, Y. Jan (1995)
dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila.The EMBO Journal, 14
S. Piatti, C. Lengauer, K. Nasmyth (1995)
Cdc6 is an unstable protein whose de novo synthesis in G1 is important for the onset of S phase and for preventing a ‘reductional’ anaphase in the budding yeast Saccharomyces cerevisiae.The EMBO Journal, 14
Corrado Santocanale, J. Diffley (1996)
ORC‐ and Cdc6‐dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.The EMBO Journal, 15
C. Liang, M. Weinreich, B. Stillman (1995)
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genomeCell, 81
H. Richardson, D. Lew, M. Henze, K. Sugimoto, S. Reed (1992)
Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in G2.Genes & development, 6 11
A. Murray (1994)
Cell cycle checkpoints.Current opinion in cell biology, 6 6
G. D'Urso, R. Marraccino, D. Marshak, J. Roberts (1990)
Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase.Science, 250 4982
J. Walter, J. Newport (1997)
Regulation of Replicon Size in Xenopus Egg ExtractsScience, 275
H. Ohkura, I. Hagan, D. Glover (1995)
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.Genes & development, 9 9
Catherine Fox, S. Loo, Andrew Dillin, Jasper Rine (1995)
The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication.Genes & development, 9 8
R. Hollingsworth, R. Sclafani (1990)
DNA metabolism gene CDC7 from yeast encodes a serine (threonine) protein kinase.Proceedings of the National Academy of Sciences of the United States of America, 87
M. Madine, Chong-Yee Khoo, A. Mills, C. Musahl, R. Laskey (1995)
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extractsCurrent Biology, 5
L. Hartwell (1976)
Sequential function of gene products relative to DNA synthesis in the yeast cell cycle.Journal of molecular biology, 104 4
L. Zou, James Mitchell, B. Stillman (1997)
CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replicationMolecular and Cellular Biology, 17
C. Fode, Benny Motro, Shida Yousefi, Mike Heffernan, James Dennis (1994)
Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.Proceedings of the National Academy of Sciences of the United States of America, 91 14
H. Estes, B. Robinson, S. Eisenberg (1992)
At least three distinct proteins are necessary for the reconstitution of a specific multiprotein complex at a eukaryotic chromosomal origin of replication.Proceedings of the National Academy of Sciences of the United States of America, 89 23
Roy Golsteyn, S. Schultz, Jiri Bartek, Andrew Ziemiecki, Thomas Ried, Erich Nigg (1994)
Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5.Journal of cell science, 107 ( Pt 6)
B. Brewer, W. Fangman (1994)
Initiation preference at a yeast origin of replication.Proceedings of the National Academy of Sciences of the United States of America, 91
B. Hu, R. Burkhart, D. Schulte, C. Musahl, R. Knippers (1993)
The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.Nucleic acids research, 21 23
G. Micklem, A. Rowley, J. Harwood, K. Nasmyth, J. Diffley (1993)
Yeast origin recognition complex is involved in DNA replication and transcriptional silencingNature, 366
K. Kitada, A. Johnson, L. Johnston, Akio SUGINOl (1993)
A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5Molecular and Cellular Biology, 13
Adele Rowley, Simon Dowell, J. Diffley (1994)
Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges.Biochimica et biophysica acta, 1217 3
Suzanne Elsasser, Feng Lou, Bin Wang, Judith Campbell, Ambrose Jong (1996)
Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases.Molecular biology of the cell, 7 11
H. Nishitani, P. Nurse (1995)
p65 cdc18 Plays a major role controlling the initiation of DNA replication in fission yeastCell, 83
F. Jacob, S. Brenner, F. Cuzin (1963)
On the Regulation of DNA Replication in BacteriaCold Spring Harbor Symposia on Quantitative Biology, 28
B. Brewer, W. Fangman (1993)
Initiation at closely spaced replication origins in a yeast chromosome.Science, 262 5140
M. Madine, Chong-Yee Khoo, A. Mills, R. Laskey (1995)
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cellsNature, 375
U. Strausfeld, M. Howell, R. Rempel, J. Maller, T. Hunt, J. Blow (1994)
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinasesCurrent Biology, 4
Julie Cocker, S. Piatti, C. Santocanale, K. Nasmyth, J. Diffley (1996)
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeastNature, 379
L. Tsai, E. Harlow, M. Meyerson (1991)
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinaseNature, 353
Hong Yan, Ankit Merchant, B. Tye (1993)
Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.Genes & development, 7 11
Leland Hartwell (1978)
Cell division from a genetic perspectiveThe Journal of Cell Biology, 77
J. Leatherwood, A. López-Girona, P. Russell (1996)
Interaction of Cdc2 and CdclS with a fission yeast ORC2-like proteinNature, 379
B. Stillman (1993)
Replicator renaissanceNature, 366
T. Kiyono, M. Fujita, Y. Hayashi, M. Ishibashi (1996)
Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family.Biochimica et biophysica acta, 1307 1
J. Diffley, Julie Cocker, S. Dowell, A. Rowley (1994)
Two steps in the assembly of complexes at yeast replication origins in vivoCell, 78
J. Lisziewicz, A. Godány, D. Agoston, H. Küntzel (1988)
Cloning and characterization of the Saccharomyces cerevisiae CDC6 gene.Nucleic acids research, 16 24
N. Shakibai, V. Kumar, S. Eisenberg (1996)
The Ku-like protein from Saccharomyces cerevisiae is required in vitro for the assembly of a stable multiprotein complex at a eukaryotic origin of replication.Proceedings of the National Academy of Sciences of the United States of America, 93 21
H. Rao, B. Stillman (1995)
The origin recognition complex interacts with a bipartite DNA binding site within yeast replicators.Proceedings of the National Academy of Sciences of the United States of America, 92 6
Ivan Todorov, Amir Attaran, S. Kearsey (1995)
BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replicationThe Journal of Cell Biology, 129
C. Hardy (1996)
Characterization of an essential Orc2p-associated factor that plays a role in DNA replicationMolecular and Cellular Biology, 16
P. Nurse, Y. Bissett (1981)
Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeastNature, 292
Christian Dahmann, J. Diffley, K. Nasmyth (1995)
S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative stateCurrent Biology, 5
D. Schulte, R. Burkhart, C. Musahl, B. Hu, C. Schlatterer, H. Hameister, R. Knippers (1995)
Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein.Journal of cell science, 108 ( Pt 4)
A. Jacqueline, Lees, Midori Saito, M. Vidal, M. Valentine, T. Look, E. Harlow, N. Dyson, K. Helin (1993)
The retinoblastoma protein binds to a family of E2F transcription factorsMolecular and Cellular Biology, 13
J. Toyn, A. Johnson, Andleland Johnston (1995)
Segregation of unreplicated chromosomes in Saccharomyces cerevisiae reveals a novel G1/M-phase checkpointMolecular and Cellular Biology, 15
S. Morana, C. Wolf, Jinfang Li, J. Reynolds, Mary Brown, A. Eastman (1996)
The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis*The Journal of Biological Chemistry, 271
K. Kitada, L. Johnston, Toshiko Sugino, A. Sugino (1992)
Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.Genetics, 131 1
T. Coleman, P. Carpenter, W. Dunphy (1996)
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free ExtractsCell, 87
C. Zhou, S. Huang, A. Jong (1989)
Molecular cloning of Saccharomyces cerevisiae CDC6 gene. Isolation, identification, and sequence analysis.The Journal of biological chemistry, 264 15
L. Hartwell (1973)
Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiaeJournal of Bacteriology, 115
A. Blumenthal, H. Kriegstein, D. Hogness (1974)
The units of DNA replication in Drosophila melanogaster chromosomes.Cold Spring Harbor symposia on quantitative biology, 38
P. Romanowski, M. Madine, A. Rowles, J. Blow, R. Laskey (1996)
The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatinCurrent Biology, 6
James Chong, P. Thömmes, J. Blow (1996)
The role of MCM/P1 proteins in the licensing of DNA replication.Trends in biochemical sciences, 21 3
K. Friedman, J. Diller, B. Ferguson, S. Nyland, B. Brewer, W. Fangman (1996)
Multiple determinants controlling activation of yeast replication origins late in S phase.Genes & development, 10 13
J. Blow, Icrf Hall (1993)
Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factorThe Journal of Cell Biology, 122
D. Schulte, Andreas Richter, Roland Rurkhart, C. Musahl, R. Knippers (1996)
Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins.European journal of biochemistry, 235 1-2
J. Blow, P. Nurse (1990)
A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extractsCell, 62
S. Dowell, P. Romanowski, J. Diffley (1994)
Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo.Science, 265 5176
S. Roth, C. Allis (1996)
Histone Acetylation and Chromatin Assembly: A Single Escort, Multiple Dances?Cell, 87
F. Fang, J. Newport (1993)
Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle.Journal of cell science, 106 ( Pt 3)
S. Bell, B. Stillman (1992)
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexNature, 357
K. Hennessy, Angela Lee, E. Chen, D. Botstein (1991)
A group of interacting yeast DNA replication genes.Genes & development, 5 6
K. Heichman, James Roberts (1996)
The Yeast CDC16 and CDC27 Genes Restrict DNA Replication to Once per Cell CycleCell, 85
Sanae Miyake, Nobuyuki Okishio, I. Samejima, Yasushi Hiraoka, Takashi Toda, Izumu Saitoh, Mitsuhiro Yanagidat (1993)
Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.Molecular biology of the cell, 4 10
H. Yoon, Seng Loo, J. Campbell (1993)
Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle.Molecular biology of the cell, 4 2
T. Kelly, G. Martin, S. Forsburg, R. Stephen, A. Russo, P. Nurse (1993)
The fission yeast cdc18 + gene product couples S phase to START and mitosisCell, 74
S. Moreno, P. Nurse (1994)
Regulation of progression through the Gl phase of the cell cycle by the rum1 + geneNature, 367
Richard Klemm, R. Austin, S. Bell (1997)
Coordinate Binding of ATP and Origin DNA Regulates the ATPase Activity of the Origin Recognition ComplexCell, 88
B. Hopwood, S. Dalton (1996)
Cdc45p assembles into a complex with Cdc46p/Mcm5p, is required for minichromosome maintenance, and is essential for chromosomal DNA replication.Proceedings of the National Academy of Sciences of the United States of America, 93 22
S. Piatti, T. Böhm, Julie Cocker, J. Diffley, K. Nasmyth (1996)
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.Genes & development, 10 12
Adele Rowley, Julie Cocker, Janet Harwood, J. Diffley (1995)
Initiation complex assembly at budding yeast replication origins begins with the recognition of a bipartite sequence by limiting amounts of the initiator, ORC.The EMBO Journal, 14
S. Loo, C. Fox, J. Rine, R. Kobayashi, B. Stillman, S. Bell (1995)
The origin recognition complex in silencing, cell cycle progression, and DNA replication.Molecular biology of the cell, 6 6
Kyung Lee, Yiran Yuan, R. Kuriyama, R. Erikson (1995)
Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1Molecular and Cellular Biology, 15
T. Su, G. Feger, P. O’Farrell (1996)
Drosophila MCM protein complexes.Molecular biology of the cell, 7 2
H. Masai, T. Miyake, K. Arai (1995)
hsk1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication.The EMBO Journal, 14
C. Epstein, F. Cross (1992)
CLB5: a novel B cyclin from budding yeast with a role in S phase.Genes & development, 6 9
Bo Li, B. Ouyang, H. Pan, Peter Reissmann, D. Slamon, R. Arceci, Luo Lu, W. Dai (1996)
prk, a Cytokine-inducible Human Protein Serine/Threonine Kinase Whose Expression Appears to be Down-regulated in Lung Carcinomas*The Journal of Biological Chemistry, 271
▪ Abstract The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.
Annual Review of Cell and Developmental Biology – Annual Reviews
Published: Nov 1, 1997
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.