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INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS

INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS ▪ Abstract The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cell and Developmental Biology Annual Reviews

INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS

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References (160)

Publisher
Annual Reviews
Copyright
Copyright © 1997 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
1081-0706
eISSN
1530-8995
DOI
10.1146/annurev.cellbio.13.1.293
pmid
9442876
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract The recent identification of proteins that recognize origins of DNA replication and control the initiation of eukaryotic DNA replication has provided critical molecular tools to dissect this process. Dynamic changes in the assembly and disassembly of protein complexes at origins are important for the initiation of DNA replication and occur throughout the cell cycle. Herein, we review the key proteins required for the initiation of DNA replication, their involvement in the protein complex assembly at replication origins, and how the cell cycle machinery regulates this process.

Journal

Annual Review of Cell and Developmental BiologyAnnual Reviews

Published: Nov 1, 1997

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