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Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure

Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart... Abstract Katz, Stuart D., Jeannette Yuen, Rachel Bijou, and Thierry H. LeJemtel. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J. Appl. Physiol. 82(5): 1488–1492, 1997.—The effects of physical training on endothelium-dependent vasodilation in skeletal muscle resistance vessels were investigated in patients with heart failure. Forearm blood flows (ml ⋅ min −1 ⋅ 100 ml −1 ) in response to brachial arterial administration of acetylcholine (5 × 10 −5 and 5 × 10 −4 M at 1 ml/min) and nitroglycerin (5 × 10 −6 and 5 × 10 −5 M at 1 ml/min) were determined by strain-gauge venous occlusion plethysmography before and after 8 wk of daily handgrip exercise in 12 patients with chronic heart failure. After 8 wk of daily handgrip exercise, the vasodilatory responses to acetylcholine significantly increased from pretraining values, i.e., 16.6 ± 2.0 vs. 8.6 ± 1.3 ml ⋅ min −1 ⋅ 100 ml −1 ( P < 0.05) and 27.5 ± 1.5 vs. 14.6 ± 1.7 ml ⋅ min −1 ⋅ 100 ml −1 ( P < 0.05), respect- ively, whereas the vasodilatory responses to nitroglycerin did not change. Handgrip exercise training appears to specifically enhance endothelium-dependent vasodilation in the forearm skeletal muscle circulation of patients with heart failure. congestive exercise physical training acetylcholine endothelium-derived relaxing factor Footnotes Address for reprint requests: T. H. LeJemtel, Albert Einstein College of Medicine, Div. of Cardiology, Forch G42, 1300 Morris Park Ave., Bronx, NY 10461. This work was previously presented in abstract form at the American College of Cardiology Scientific Sessions in Anaheim, CA, in March 1993. Copyright © 1997 the American Physiological Society http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Applied Physiology The American Physiological Society

Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure

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Publisher
The American Physiological Society
Copyright
Copyright © 2011 the American Physiological Society
ISSN
8750-7587
eISSN
1522-1601
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Abstract

Abstract Katz, Stuart D., Jeannette Yuen, Rachel Bijou, and Thierry H. LeJemtel. Training improves endothelium-dependent vasodilation in resistance vessels of patients with heart failure. J. Appl. Physiol. 82(5): 1488–1492, 1997.—The effects of physical training on endothelium-dependent vasodilation in skeletal muscle resistance vessels were investigated in patients with heart failure. Forearm blood flows (ml ⋅ min −1 ⋅ 100 ml −1 ) in response to brachial arterial administration of acetylcholine (5 × 10 −5 and 5 × 10 −4 M at 1 ml/min) and nitroglycerin (5 × 10 −6 and 5 × 10 −5 M at 1 ml/min) were determined by strain-gauge venous occlusion plethysmography before and after 8 wk of daily handgrip exercise in 12 patients with chronic heart failure. After 8 wk of daily handgrip exercise, the vasodilatory responses to acetylcholine significantly increased from pretraining values, i.e., 16.6 ± 2.0 vs. 8.6 ± 1.3 ml ⋅ min −1 ⋅ 100 ml −1 ( P < 0.05) and 27.5 ± 1.5 vs. 14.6 ± 1.7 ml ⋅ min −1 ⋅ 100 ml −1 ( P < 0.05), respect- ively, whereas the vasodilatory responses to nitroglycerin did not change. Handgrip exercise training appears to specifically enhance endothelium-dependent vasodilation in the forearm skeletal muscle circulation of patients with heart failure. congestive exercise physical training acetylcholine endothelium-derived relaxing factor Footnotes Address for reprint requests: T. H. LeJemtel, Albert Einstein College of Medicine, Div. of Cardiology, Forch G42, 1300 Morris Park Ave., Bronx, NY 10461. This work was previously presented in abstract form at the American College of Cardiology Scientific Sessions in Anaheim, CA, in March 1993. Copyright © 1997 the American Physiological Society

Journal

Journal of Applied Physiology – The American Physiological Society

Published: May 1, 1997

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