Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Genetic aspects of inflammation and cancer.

Genetic aspects of inflammation and cancer. Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Biochemical journal Pubmed

Genetic aspects of inflammation and cancer.

Hold, Georgina L; El-Omar, Emad M
The Biochemical journal , Volume 410 (2): 11 – Mar 17, 2008
Download PDF

Genetic aspects of inflammation and cancer.


Abstract

Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis.

Loading next page...
 
/lp/pubmed/genetic-aspects-of-inflammation-and-cancer-eadei3vJz6

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

ISSN
0264-6021
DOI
10.1042/BJ20071341
pmid
18254728

Abstract

Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis.

Journal

The Biochemical journal – Pubmed

Published: Mar 17, 2008

References

  • Infections as a major preventable cause of human cancer
    Kuper
  • Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2
    Gupta
  • Inflammation and cancer II: role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy
    Macarthur
  • Inflammation and cancer: back to Virchow?
    Balkwill
  • Inflammation and cancer
    Coussens
  • Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
    Schoppmann
  • Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    Kawanishi
  • Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin
    Lechner
  • Genetic and epigenetic damage induced by reactive nitrogen species: implications in carcinogenesis
    Ohshima
  • Prevention of human cancer by modulation of chronic inflammatory processes
    Ohshima
  • Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis
    Jaiswal
  • DNA damage and genotoxicity by nitric oxide
    Tamir
  • Nitric oxide and oxygen radicals in infection, inflammation, and cancer
    Maeda
  • Free radicals, metals and antioxidants in oxidative stress-induced cancer
    Valko
  • Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model
    Sandhu
  • Oxyradicals and DNA damage
    Marnett
  • Oxidative DNA damage: mechanisms, mutation, and disease
    Cooke
  • Mitochondrial DNA in human malignancy
    Penta
  • Oxidant signals and oxidative stress
    Finkel
  • Potential molecular mechanisms of oxidant-induced carcinogenesis
    Jackson
  • p21ras as a common signaling target of reactive free radicals and cellular redox stress
    Lander
  • Nitric oxide as a modulator of apoptosis
    Li
  • Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms
    Cui
  • Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
    Hofseth
  • p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis
    Hussain
  • Formation of 8-nitroguanosine in cellular RNA as a biomarker of exposure to reactive nitrogen species
    Masuda
  • Transition mutation in codon 248 of the p53 tumor suppressor gene induced by reactive oxygen species and a nitric oxide-releasing compound
    Souici
  • Mitochondrial redox control of matrix metalloproteinases
    Nelson
  • Sublethal oxidative stress inhibits tumor cell adhesion and enhances experimental metastasis of murine mammary carcinoma
    Kundu
  • Integrins and coagulation: a role for ROS/redox signaling?
    Gregg
  • Oxidative stress and cancer: have we moved forward?
    Halliwell
  • Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer
    Thomas
  • A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction
    Lander
  • Tumor angiogenesis and accessibility: role of vascular endothelial growth factor
    Jain
  • Targeting HIF-1 for cancer therapy
    Semenza
  • Hypoxia-inducible factor-1 in human breast and prostate cancer
    Kimbro
  • Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    Salceda
  • Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1
    Semenza
  • Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation
    Jung
  • IL-1β-mediated up-regulation of HIF-1α via an NFκB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
    Jung
  • Hypoxia: a key regulatory factor in tumour growth
    Harris
  • Differential prognostic impact of hypoxia induced and diffuse HIF-1α expression in invasive breast cancer
    Vleugel
  • Inflammation, carcinogenesis and cancer
    Fitzpatrick
  • Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential
    Tsujii
  • COX-2: a target for colon cancer prevention
    Marnett
  • Cyclooxygenase-2 and carcinogenesis
    Prescott
  • The role of cyclooxygenases in inflammation, cancer, and development
    Williams
  • NSAIDs and cancer prevention: targets downstream of COX-2
    Cha
  • Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells
    Yang
  • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis
    Castellone
  • Wnt signaling in the intestinal epithelium: from endoderm to cancer
    Gregorieff
  • Non-steroidal anti-inflammatory drugs in prevention of gastric cancer
    Dai
  • Aspirin use and lung, colon, and breast cancer incidence in a prospective study
    Schreinemachers
  • Aspirin and reduced risk of esophageal carcinoma
    Funkhouser
  • Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    Chan
  • Inflammatory mediators and nuclear receptor signaling in colorectal cancer
    Wang
  • Chemoprevention of colorectal cancer with cyclooxygenase-2 inhibitors: two steps forward, one step back
    Bertagnolli
  • NF-κB in cancer: from innocent bystander to major culprit
    Karin
  • Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer
    Leung
  • Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin E receptors, and angiogenic factors by cyclooxygenase-1
    Sales
  • Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    Gupta
  • Toll-like receptors and innate immunity
    Medzhitov
  • Toll-like receptors: critical proteins linking innate and acquired immunity
    Akira
  • NF-κB and cancer: mechanisms and targets
    Karin
  • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    Sen
  • A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes
    Singh
  • Nuclear factor-κB in cancer development and progression
    Karin
  • NF-κB: linking inflammation and immunity to cancer development and progression
    Karin
  • Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention
    Chun
  • The two NF-κB activation pathways and their role in innate and adaptive immunity
    Bonizzi
  • B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
    Neri
  • CK2 is a C-terminal IκB kinase responsible for NF-κB activation during the UV response
    Kato
  • Nuclear factor-κB: a friend or a foe in cancer? Biochem
    Shishodia
  • IKK/NF-κB signaling: balancing life and death: a new approach to cancer therapy
    Luo
  • Inflammation and cancer: how hot is the link?
    Aggarwal
  • NF-κB signaling and carcinogenesis
    Okamoto
  • Bcl-2 suppresses apoptosis resulting from disruption of the NF-κB survival pathway
    Herrmann
  • Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen
    Palayoor
  • The nuclear factor-κB RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells
    Wang
  • Regulation of NF-κB activity by IκB-related proteins in adenocarcinoma cells
    Dejardin
  • NF-κB functions as a tumour promoter in inflammation-associated cancer
    Pikarsky
  • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Greten
  • Molecular mechanisms of constitutive NF-κB/Rel activation in Hodgkin/Reed-Sternberg cells
    Krappmann
  • Constitutive activation of NF-κB in primary adult T-cell leukemia cells
    Mori
  • Nuclear factor-κB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis
    Bharti
  • Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor
    Sanda
  • Cancer and the chemokine network
    Balkwill
  • Inflammation-associated cancer: NF-κB is the lynchpin
    Li
  • NF-κB activation in development and progression of cancer
    Inoue
  • Cancer research. Inflammation and cancer: the link grows stronger
    Marx
  • Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
    Nakanishi
  • Inflammation, cancer and chemoresistance: taking advantage of the toll-like receptor signaling pathway
    Chen
  • NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
    Bentires-Alj
  • Autophagy signaling and the cogwheels of cancer
    Botti
  • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    Aita
  • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    Liang
  • Role of autophagy in cancer: management of metabolic stress
    Jin
  • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    Degenhardt
  • Defective autophagy leads to cancer
    Edinger
  • Eating oneself and uninvited guests: autophagy-related pathways in cellular defense
    Levine
  • Autophagy, mitochondrial quality control, and oncogenesis
    Jin
  • The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains
    Zhang
  • Autophagy as a cell death and tumor suppressor mechanism
    Gozuacik
  • Autophagy and signaling: their role in cell survival and cell death
    Codogno
  • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    Reef
  • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    Crighton
  • Interleukin-10-deficient mice develop chronic enterocolitis
    Kuhn
  • Dominant nonresponsiveness to Helicobacter pylori infection is associated with production of interleukin 10 but not gamma interferon
    Sutton
  • Interleukin-1 polymorphisms associated with increased risk of gastric cancer
    El Omar
  • Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    El Omar
  • Cytokines in cancer pathogenesis and cancer therapy
    Dranoff
  • Tumour-educated macrophages promote tumour progression and metastasis
    Pollard
  • Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells
    Miyamoto
  • TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Becker
  • Serum interleukin-6 levels reflect the disease status of colorectal cancer
    Chung
  • Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells
    Schneider
  • Tumor necrosis factor-α induces apoptosis associated with poly(ADP-ribose) polymerase cleavage in HT-29 colon cancer cells
    Vaculova
  • Inflammation, a key event in cancer development
    Lu
  • Role of host genes in sporadic gastric cancer
    El-Omar
  • Searching for genetic determinants in the new millennium
    Risch
  • Cellular and molecular aspects of gastric cancer
    Smith
  • The development of atrophic gastritis: Helicobacter pylori and the effects of acid suppressive therapy
    Kuipers
  • The importance of interleukin 1β in Helicobacter pylori associated disease
    El Omar
  • Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma
    Figueiredo
  • A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Machado
  • Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    Machado
  • Interleukin-1 gene polymorphisms and gastric cancer risk in a high-risk Italian population
    Palli
  • Interleukin 1β polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    Furuta
  • Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China
    Zeng
  • Role of the polymorphic IL-1B, IL-1RN and TNF-A genes in distal gastric cancer in Mexico
    Garza-Gonzalez
  • Interleukin-1β gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection
    Wang
  • Impact of interleukin-1β genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    Tanaka
  • Interleukin-1β gene in esophageal, gastric and colorectal carcinomas
    Ito
  • Functional variants in the promoter of interleukin-1β are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population
    Liu
  • Interleukin 1β and tumour necrosis factor α inhibit acid secretion in cultured rabbit parietal cells by multiple pathways
    Beales
  • TNFα−308G/A polymorphism as a risk factor for HPV associated cervical cancer in Indian population
    Kohaar
  • Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma
    Duell
  • Interleukin-10 gene promoter polymorphisms and the risk of nasopharyngeal carcinoma
    Wei
  • Cytokine gene polymorphisms, cancer susceptibility, and prognosis
    Howell
  • The IL-8-251 promoter polymorphism is associated with high IL-8 production, severe inflammation and increased risk of pre-malignant changes in H-pylori positive subjects
    Smith
  • Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan
    Taguchi
  • Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor α and risk of gastric cancer in a Chinese population
    Lu
  • The polymorphism interleukin 8 -251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population
    Ohyauchi
  • The −251T allele of the interleukin-8 promoter is associated with increased risk of gastric carcinoma featuring diffuse-type histopathology in Chinese population
    Lee
  • Induction of host signal transduction pathways by Helicobacter pylori
    Segal
  • TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    Arbour
  • Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299Gly polymorphism is associated with Crohn's disease and ulcerative colitis
    Franchimont
  • Toll-like receptor 4 and atherogenesis
    Kiechl
  • Toll-like receptor 4 polymorphisms and atherogenesis
    Kiechl
  • Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock
    Lorenz
  • Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
    Higgins
  • A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors
    Hold
  • Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis
    Sanduleanu
  • Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice
    Zavros
  • A polymorphism of the interleukin-1β gene influences survival in pancreatic cancer
    Barber
  • Analysis of TNFB and TNFA NcoI RFLP in colorectal cancer
    Park
  • Low-penetrance genes and their involvement in colorectal cancer susceptibility
    de Jong