Access the full text.
Sign up today, get DeepDyve free for 14 days.
D. Bayliss, D. Millhorn (1991)
Chronic estrogen exposure maintains elevated levels of progesterone receptor mRNA in guinea pig hypothalamus.Brain research. Molecular brain research, 10 2
R. Steinmetz, N. Mitchner, Andrea Grant, D. Allen, R. Bigsby, N. Ben-Jonathan (1998)
The xenoestrogen bisphenol A induces growth, differentiation, and c-fos gene expression in the female reproductive tract.Endocrinology, 139 6
K. Kubo, O. Arai, R. Ogata, M. Omura, T. Hori, S. Aou (2001)
Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the ratNeuroscience Letters, 304
R. Simerly, A. Carr, M. Zee, D. Lorang (1996)
Ovarian Steroid Regulation of Estrogen and Progesterone Receptor Messenger Ribonucleic Acid in the Anteroventral Periventricular Nucleus of the RatJournal of Neuroendocrinology, 8
L. Doncarlos, G. Greene, J. Morrell (1989)
Estrogen plus progesterone increases progestin receptor immunoreactivity in the brain of ovariectomized guinea pigs.Neuroendocrinology, 50 6
F. Farabollini, S. Porrini, F. Dessì-Fulgheri, F. Dessì-Fulgheri (1999)
Perinatal Exposure to the Estrogenic Pollutant Bisphenol A Affects Behavior in Male and Female RatsPharmacology Biochemistry and Behavior, 64
Carla Farmer, Timothy Isakson, D. Coy, K. Renner (1996)
In vivo evidence for progesterone dependent decreases in serotonin release in the hypothalamus and midbrain central grey: relation to the induction of lordosisBrain Research, 711
M. McCarthy, D. Pfaff, S. Schwartz‐Giblin (2004)
Midbrain central gray GABAA receptor activation enhances, and blockade reduces, sexual behavior in the female ratExperimental Brain Research, 86
N. Weiland, C. Orikasa, S. Hayashi, B. McEwen (1997)
Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female ratsJournal of Comparative Neurology, 388
D. Hardy (1972)
Sexual behavior in continuously cycling rats.Behaviour, 41 3
P. Shughrue, M. Lane, I. Merchenthaler (1997)
Regulation of progesterone receptor messenger ribonucleic acid in the rat medial preoptic nucleus by estrogenic and antiestrogenic compounds: an in situ hybridization study.Endocrinology, 138 12
J. Debold, C. Frye (1994)
Progesterone and the neural mechanisms of hamster sexual behaviorPsychoneuroendocrinology, 19
(2000)
Printed in U.S.A. Copyright © 2000 by The Endocrine Society Exposure of Newborn Male and Female Rats to Environmental Estrogens: Delayed and Sustained Hyperprolactinemia and Alterations in Estrogen Receptor Expression*
J. Blaustein, J. King, D. Toft, J. Turcotte (1988)
Immunocytochemical localization of estrogen-induced progestin receptors in guinea pig brainBrain Research, 474
T. Funabashi, M. Kawaguchi, F. Kimura (2001)
The Endocrine Disrupters Butyl Benzyl Phthalate and Bisphenol A Increase the Expression of Progesterone Receptor Messenger Ribonucleic Acid in the Preoptic Area of Adult Ovariectomized RatsNeuroendocrinology, 74
C. Dudley, R. Moss (1985)
LHRH and mating behavior: Sexual receptivity versus sexual preferencePharmacology Biochemistry and Behavior, 22
K. Hagihara, S. Hirata, T. Osada, M. Hirai, J. Kato (1992)
Distribution of cells containing progesterone receptor mRNA in the female rat di- and telencephalon: an in situ hybridization study.Brain research. Molecular brain research, 14 3
D. Olster, Ilene Auerbach (2000)
Deficits in Progesterone-Facilitated Sexual Behaviors and Forebrain Estrogen and Progestin Receptors in Obese Female Zucker RatsNeuroendocrinology, 72
S. Kalra (1993)
Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge.Endocrine reviews, 14 5
F. Beach (1976)
Sexual attractivity, proceptivity, and receptivity in female mammalsHormones and Behavior, 7
Richard Green, Richard Green, William Luttge, William Luttge, R. Whalen, R. Whalen (1970)
Induction of receptivity in ovariectomized female rats by a single intravenous injection of estradiol-17 .Physiology & behavior, 5 2
L. Takahashi, R. Lisk (1985)
Diencephalic sites of progesterone action for inhibiting aggression and facilitating sexual receptivity in estrogen-primed golden hamsters.Endocrinology, 116 6
T. Obata, S. Kubota (2000)
Formation of hydroxy radicals by environmental estrogen-like chemicals in rat striatumNeuroscience Letters, 296
J. Pfaus, W. Smith, C. Coopersmith (1999)
Appetitive and Consummatory Sexual Behaviors of Female Rats in Bilevel Chambers I. A Correlational and Factor Analysis and the Effects of Ovarian HormonesHormones and Behavior, 35
B. Parsons, N. MacLusky, L. Krey, D. Pfaff, B. McEwen (1980)
The temporal relationship between estrogen-inducible progestin receptors in the female rat brain and the time course of estrogen activation of mating behavior.Endocrinology, 107 3
(1980)
The temporal relationship between estrogen-inducible progestin receptors in the female rat brain and the time course of estrogen activation of mating
Khurana (2000)
Exposure of newborn male and female rats to environmental estrogens: Delayed and sustained hyperprolactinemia and alterations in estrogen receptor expressionEndocrinology, 141
S. Laws, S. Carey, J. Ferrell, Gerald Bodman, R. Cooper (2000)
Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.Toxicological sciences : an official journal of the Society of Toxicology, 54 1
(1994)
Cellular and molecular mechanisms of female reproductive behaviors
F. Saal, P. Cooke, D. Buchanan, P. Palanza, K. Thayer, S. Nagel, S. Parmigiani, W. Welshons (1998)
A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and BehaviorToxicology and Industrial Health, 14
L. Swanson (1984)
The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5Trends in Neurosciences, 7
R. Steinmetz, N. Brown, D. Allen, R. Bigsby, N. Ben-Jonathan (1997)
The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.Endocrinology, 138 5
Bayliss Bayliss, Millhorn Millhorn (1991)
Chronic estrogen exposure maintains elevated levels of progesterone receptor mRNA in guinea pig hypothalamusMol Brain Res, 10
S. Ogawa, UE Olazabal, I. Parhar, D. Pfaff (1994)
Effects of intrahypothalamic administration of antisense DNA for progesterone receptor mRNA on reproductive behavior and progesterone receptor immunoreactivity in female rat, 14
A. Lauber, G. Romano, D. Pfaff (1991)
Sex difference in estradiol regulation of progestin receptor mRNA in rat mediobasal hypothalamus as demonstrated by in situ hybridization.Neuroendocrinology, 53 6
O. Conneely (2001)
Perspective: female steroid hormone action.Endocrinology, 142 6
T. Funabashi, S. Kleopoulos, P. Brooks, F. Kimura, D. Pfaff, K. Shinohara, C. Mobbs (2000)
Changes in estrogenic regulation of estrogen receptor α mRNA and progesterone receptor mRNA in the female rat hypothalamus during aging: an in situ hybridization studyNeuroscience Research, 38
Hagihara Hagihara, Hirata Hirata, Osada Osada, Hirai Hirai, Kato Kato (1992)
Distribution of cells containing progesterone receptor mRNA in the female rat di‐ and telencephalon: an in situ hybridization studyMol Brain Res, 14
Margaret McCarthy, S. Kleopoulos, C. Mobbs, Donald Pfaff (1994)
Infusion of antisense oligodeoxynucleotides to the oxytocin receptor in the ventromedial hypothalamus reduces estrogen-induced sexual receptivity and oxytocin receptor binding in the female rat.Neuroendocrinology, 59 5
S. Alves, N. Weiland, S. Hayashi, B. McEwen (1998)
Immunocytochemical localization of nuclear estrogen receptors and progestin receptors within the rat dorsal raphe nucleusJournal of Comparative Neurology, 391
L. Takahashi, R. Lisk (1988)
Dual progesterone action in diencephalon facilitates the induction of sexual receptivity in estrogen-primed golden hamstersPhysiology & Behavior, 44
G. Romano, A. Krust, D. Pfaff (1989)
Expression and estrogen regulation of progesterone receptor mRNA in neurons of the mediobasal hypothalamus: an in situ hybridization study.Molecular endocrinology, 3 8
X. Long, Kathleen Burke, R. Bigsby, K. Nephew (2001)
Effects of the Xenoestrogen Bisphenol a on Expression of Vascular Endothelial Growth Factor (VEGF) in the RatExperimental Biology and Medicine, 226
L. Takahashi, R. Lisk (1986)
Intracranial sites regulating the biphasic action of progesterone in estrogen-primed golden hamsters.Endocrinology, 119 6
A. Tohei, S. Suda, K. Taya, T. Hashimoto, H. Kogo (2001)
Bisphenol a Inhibits Testicular Functions and Increases Luteinizing Hormone Secretion in Adult Male RatsExperimental Biology and Medicine, 226
A. Traish, H. Wotiz (1990)
Monoclonal and polyclonal antibodies to human progesterone receptor peptide-(533-547) recognize a specific site in unactivated (8S) and activated (4S) progesterone receptor and distinguish between intact and proteolyzed receptors.Endocrinology, 127 3
A. Aloisi, D. Seta, I. Ceccarelli, F. Farabollini (2001)
Bisphenol-A differently affects estrogen receptors-α in estrous-cycling and lactating female ratsNeuroscience Letters, 310
K. Renner, L. Krey, V. Luine (1987)
Effect of progesterone on monoamine turnover in the brain of the estrogen-primed ratBrain Research Bulletin, 19
K. Moody, J. Steinman, B. Komisaruk, N. Adler (1994)
Pelvic neurectomy blocks oxytocin-facilitated sexual receptivity in ratsPhysiology & Behavior, 56
R. Sharpe, J. Fisher, M. Millar, S. Jobling, J. Sumpter (1995)
Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.Environmental Health Perspectives, 103
Recently, we reported that bisphenol A (BPA), an endocrine disrupter, increased progesterone receptor (PR) mRNA in the preoptic area (POA) in adult ovariectomized rats. In the present study, we examined whether BPA also induced expression of PR proteins in both the POA and the ventromedial hypothalamic nucleus (VMH), and whether those proteins were involved in the induction of sexual behaviour. Two weeks after ovariectomy, rats received a subcutaneous (s.c.) injection of BPA, 17β‐oestradiol or vehicle. Twenty‐four hours after the injection, the rats were killed and their tissues were examined by immunocytochemistry. Some rats that received a s.c. injection of BPA, E2 or vehicle alone on the day before were injected with progesterone at 15.00 h and examined for sexual behaviour 5–7 h later. As expected, injection of 10 µg E2 significantly increased the number of PR immunoreactive cells in both the POA and the VMH compared to the number after injection of vehicle alone. In both the POA and the VMH, injection of BPA at a dose of 10 mg also significantly increased the number of PR immunoreactive cells compared to the number after injection of sesame oil alone. Furthermore, BPA induced a dose‐dependent increase in the number of PR immunoreactive cells in both the POA and the VMH, demonstrating that the number of PR cells was significantly increased by as little as 100 µg of BPA. Ovariectomized (OVX) rats that were primed with 10 mg of BPA, followed by 1 mg of progesterone, displayed mainly rejection behaviour, but not lordosis as typically observed in OVX rats primed with E2 followed by progesterone. The present study suggests that BPA influences reproductive functions, including sexual behaviour even in adulthood, by altering the PR system in the hypothalamus.
Journal of Neuroendocrinology – Wiley
Published: Feb 1, 2003
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.