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Possible association of a cholecystokinin promotor polymorphism (CCK‐36CT) with panic disorder

Possible association of a cholecystokinin promotor polymorphism (CCK‐36CT) with panic disorder We searched for mutations in the CCK gene in panic disorder with single‐strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C→T transition at position −36 (CCK−36C→T) in a GC box, a binding site for transcription factor Sp1, in the promotor region. The allele frequency was 0.168 (95% CI, 0.116–0.221) in 98 persons with panic disorder and 0.083 (95% CI, 0.059–0.107) in 247 geographically matched, unscreened controls. A transmission disequilibrium test based on panic disorder as the affected phenotype was nonsignificant (X2 = 0.93), but when panic disorder or attacks were considered as affected, statistically significant transmission disequilibrium was detected (X2 = 4.00, P < 0.05). Linkage analysis was uninformative. In exploratory analyses to search for clinical correlations, the “T” allele was found in 59% of 22 persons with panic attacks but not panic disorder, compared with 31% of those who met the criteria for panic disorder. An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results noted above, but if the provisional association can be replicated, the findings are consistent with CCK−36C→T being a disease‐susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:228–234, 1998. © 1998 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Medical Genetics Part A Wiley

Possible association of a cholecystokinin promotor polymorphism (CCK‐36CT) with panic disorder

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References (34)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1552-4825
eISSN
1552-4833
DOI
10.1002/(SICI)1096-8628(19980508)81:3<228::AID-AJMG5>3.0.CO;2-S
Publisher site
See Article on Publisher Site

Abstract

We searched for mutations in the CCK gene in panic disorder with single‐strand conformational polymorphism (SSCP) analysis of the three exons and promotor region of the gene. We found a C→T transition at position −36 (CCK−36C→T) in a GC box, a binding site for transcription factor Sp1, in the promotor region. The allele frequency was 0.168 (95% CI, 0.116–0.221) in 98 persons with panic disorder and 0.083 (95% CI, 0.059–0.107) in 247 geographically matched, unscreened controls. A transmission disequilibrium test based on panic disorder as the affected phenotype was nonsignificant (X2 = 0.93), but when panic disorder or attacks were considered as affected, statistically significant transmission disequilibrium was detected (X2 = 4.00, P < 0.05). Linkage analysis was uninformative. In exploratory analyses to search for clinical correlations, the “T” allele was found in 59% of 22 persons with panic attacks but not panic disorder, compared with 31% of those who met the criteria for panic disorder. An association between the CCK polymorphism and panic disorder cannot be considered established due to the inconsistencies in the results noted above, but if the provisional association can be replicated, the findings are consistent with CCK−36C→T being a disease‐susceptibility allele that alone is neither necessary nor sufficient to cause panic disorder but that increases vulnerability by acting epistatically. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 81:228–234, 1998. © 1998 Wiley‐Liss, Inc.

Journal

American Journal of Medical Genetics Part A – Wiley

Published: Aug 8, 1998

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