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Proteolytic Processing of Picornaviral Polyprotein

Proteolytic Processing of Picornaviral Polyprotein THE PICORNAVIRUS FAMILY The family of picomaviruses lists among its members a diverse variety of pathogenic agents. The modest protein capsid structures and small RNA genomes that characterize this medical and agricultural importance of picornavirus-caused diseases. family (pieD = small, rna = RNA), belay the Infection with rhinovirus for example, better known as the common cold, is among the most prevalent and acute of human upper-respiratory illnesses. Each year this virus exacts high tolls from every economic and social institu603 0066-4227/90/1001-0603$02. 00 PALMENBERG tion, as cold-related absenteeism is the single largest cause of lost work days for schools and businesses. Poliovirus, another well known member of the picornavirus family, has likewise afflicted human populations for as long as recorded history. The tombs of ancient pharaohs faithfully depict the withered limbs and crippling paralysis effected by this virus. Even today, in the presence of modem vaccines and sanitation technology, many thousands of new cases are chronicled annually, especially in developing countries. The unfortunate results produce economic hardships from loss of productive manpower and from the obviously difficult medical burdens incurred in patient care. Animal populations are also susceptible to picornavirus infections. Foot­ and-mouth disease virus (FMDV) is one of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Microbiology Annual Reviews

Proteolytic Processing of Picornaviral Polyprotein

Palmenberg, A C
Annual Review of Microbiology , Volume 44 (1) – Oct 1, 1990
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Publisher
Annual Reviews
Copyright
Copyright 1990 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4227
eISSN
1545-3251
DOI
10.1146/annurev.mi.44.100190.003131
pmid
2252396
Publisher site
See Article on Publisher Site

Abstract

THE PICORNAVIRUS FAMILY The family of picomaviruses lists among its members a diverse variety of pathogenic agents. The modest protein capsid structures and small RNA genomes that characterize this medical and agricultural importance of picornavirus-caused diseases. family (pieD = small, rna = RNA), belay the Infection with rhinovirus for example, better known as the common cold, is among the most prevalent and acute of human upper-respiratory illnesses. Each year this virus exacts high tolls from every economic and social institu603 0066-4227/90/1001-0603$02. 00 PALMENBERG tion, as cold-related absenteeism is the single largest cause of lost work days for schools and businesses. Poliovirus, another well known member of the picornavirus family, has likewise afflicted human populations for as long as recorded history. The tombs of ancient pharaohs faithfully depict the withered limbs and crippling paralysis effected by this virus. Even today, in the presence of modem vaccines and sanitation technology, many thousands of new cases are chronicled annually, especially in developing countries. The unfortunate results produce economic hardships from loss of productive manpower and from the obviously difficult medical burdens incurred in patient care. Animal populations are also susceptible to picornavirus infections. Foot­ and-mouth disease virus (FMDV) is one of

Journal

Annual Review of Microbiology – Annual Reviews

Published: Oct 1, 1990

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