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H. Libouban, M. Moreau, E. Legrand, M. Audran, M. Basle´, D. Chappard (2002)
Comparison of Histomorphometric Descriptors of Bone Architecture with Dual-Energy X-ray Absorptiometry for Assessing Bone Loss in the Orchidectomized RatOsteoporosis International, 13
F. Schanne, T. Dowd, R. Gupta, J. Rosen (1990)
Effect of lead on parathyroid hormone-induced responses in rat osteoblastic osteosarcoma cells (ROS 17/2.8) using 19F-NMR.Biochimica et biophysica acta, 1054 2
S Viguet-Carrin, JP Roux, ME Arlot (2005)
Contribution of the advanced glycation end product pentosidine to compressive biomechanical properties of human lumbar vertebraeJ Bone Miner Res, 20
Jae-Young Rho, Marcel Roy, Ting Tsui, G. Pharr (1999)
Elastic properties of microstructural components of human bone tissue as measured by nanoindentation.Journal of biomedical materials research, 45 1
R. Martin, D. Boardman (1993)
The effects of collagen fiber orientation, porosity, density, and mineralization on bovine cortical bone bending properties.Journal of biomechanics, 26 9
DR Eyre (1981)
Cross-link maturation in bone collagenDev Biochem, 22
E. Paschalis, E. Dicarlo, F. Betts, P. Sherman, R. Mendelsohn, A. Boskey (1996)
FTIR microspectroscopic analysis of human osteonal boneCalcified Tissue International, 59
James Campbell, R. Rosier, L. Novotny, J. Puzas (2004)
The Association between Environmental Lead Exposure and Bone Density in ChildrenEnvironmental Health Perspectives, 112
C. Laet, B. Hout, H. Burger, A. Hofman, H. Pols (1997)
Bone density and risk of hip fracture in men and women: cross sectional analysisBMJ, 315
J. Aaron, M. Vernejoul, J. Kanis (1991)
The effect of sodium fluoride on trabecular architecture.Bone, 12 5
P. Roschger, H. Gupta, A. Berzlanovich, G. Ittner, D. Dempster, D. Dempster, P. Fratzl, F. Cosman, F. Cosman, M. Parisien, R. Lindsay, R. Lindsay, J. Nieves, J. Nieves, K. Klaushofer (2003)
Constant mineralization density distribution in cancellous human bone.Bone, 32 3
S. Lees, K. Prostak, V. Ingle, K. Kjoller (1994)
The loci of mineral in turkey leg tendon as seen by atomic force microscope and electron microscopyCalcified Tissue International, 55
Georges Boivin, Paul Lips, Susan Ott, K. Harper, S. Sarkar, K. Pinette, P. Meunier (2003)
Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women.The Journal of clinical endocrinology and metabolism, 88 9
P. Odetti, S. Rossi, F. Monacelli, A. Poggi, M. Cirnigliaro, M. Federici, A. Federici (2005)
Advanced Glycation End Products and Bone Loss during AgingAnnals of the New York Academy of Sciences, 1043
(1999)
Calcium phosphates in demineralization/ remineralization processes
D. Eyre (1987)
Collagen cross-linking amino acids.Methods in enzymology, 144
G. Boivin, S. Vedi, D. Purdie, J. Compston, P. Meunier (2005)
Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women.Bone, 36 3
L. Knott, C. Whitehead, R. Fleming, A. Bailey (1995)
Biochemical changes in the collagenous matrix of osteoporotic avian bone.The Biochemical journal, 310 ( Pt 3)
T. Keaveny, E. Wachtel, X. Guo, W. Hayes (1994)
Mechanical behavior of damaged trabecular bone.Journal of biomechanics, 27 11
Adele Boskey, Edward DiCarlo, E. Paschalis, P. West, R. Mendelsohn (2005)
Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigationOsteoporosis International, 16
D. Black, S. Cummings, D. Karpf, J. Cauley, D. Thompson, M. Nevitt, D. Bauer, H. Genant, W. Haskell, R. Marcus, S. Ott, J. Torner, S. Quandt, T. Reiss, K. Ensrud (1996)
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fracturesThe Lancet, 348
D. Reilly, A. Burstein, V. Frankel (1974)
The elastic modulus for bone.Journal of biomechanics, 7 3
P. Garnero, E. Sornay‐Rendu, M. Chapuy, P. Delmas (1996)
Increased bone turnover in late postmenopausal women is a major determinant of osteoporosisJournal of Bone and Mineral Research, 11
F. Evans, R. Vincentelli (1969)
Relation of collagen fiber orientation to some mechanical properties of human cortical bone.Journal of biomechanics, 2 1
M. Alikhani, Z. Alikhani, Coy Boyd, Christine Maclellan, M. Raptis, Rongkun Liu, N. Pischon, P. Trackman, L. Gerstenfeld, D. Graves (2007)
Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.Bone, 40 2
J. Currey (2003)
Role of collagen and other organics in the mechanical properties of boneOsteoporosis International, 14
A. Charonis, E. Tsilibary (1992)
Structural and Functional Changes of Laminin and Type IV Collagen After Nonenzymatic GlycationDiabetes, 41
V. Ziv, I. Sabanay, T. Arad, W. Traub, S. Weiner (1996)
Transitional structures in lamellar boneMicroscopy Research and Technique, 33
Jie Xu, J. Rho, J. Rho, S. Mishra, Z. Fan (2003)
Atomic force microscopy and nanoindentation characterization of human lamellar bone prepared by microtome sectioning and mechanical polishing technique.Journal of biomedical materials research. Part A, 67 3
J. Termine, P. Robey, L. Fisher, H. Shimokawa, M. Drum, K. Conn, G. Hawkins, J. Cruz, K. Thompson (1984)
Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta.Proceedings of the National Academy of Sciences of the United States of America, 81 7
Katie Lundon, M. Dumitriu, M. Grynpas (1994)
The long-term effect of ovariectomy on the quality and quantity of cancellous bone in young macaques.Bone and mineral, 24 2
F. Coe, M. Favus (1992)
Disorders of bone and mineral metabolismJournal of Pediatric Orthopaedics, 12
KA Gross, CC Berndt (2002)
Biomedical application of apatites. Phosphates: Geochemical Geobiological, and Materials ImportanceRev Mineral Geochem, 48
P. Dargent-Molina, S. Piault, G. Bréart, E. Group (2003)
A comparison of different screening strategies to identify elderly women at high risk of hip fracture: results from the EPIDOS prospective studyOsteoporosis International, 14
A. Baig, John Fox, R. Young, Zeren Wang, J. Hsu, W. Higuchi, A. Chhettry, Zhuang Hong, M. Otsuka (1999)
Relationships Among Carbonated Apatite Solubility, Crystallite Size, and Microstrain ParametersCalcified Tissue International, 64
E. Paschalis, F. Betts, Edward DiCarlo, Richard Mendelsohn, A. Boskey (1997)
FTIR Microspectroscopic Analysis of Normal Human Cortical and Trabecular BoneCalcified Tissue International, 61
J. Elliott (2002)
Calcium Phosphate BiomineralsReviews in Mineralogy & Geochemistry, 48
H. Gupta, S. Krauss, Jong Seto, W. Wagermaier, M. Kerschnitzki, G. Benecke, P. Zaslansky, P. Boesecke, S. Funari, H. Kirchner, P. Fratzl (2005)
Nanoscale deformation mechanisms in bone.Nano letters, 5 10
I. Jäger, P. Fratzl (2000)
Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles.Biophysical journal, 79 4
K. Kendall (1975)
Control of cracks by interfaces in compositesProceedings of the Royal Society of London. A. Mathematical and Physical Sciences, 341
Christopher Hernandez, Simon Tang, Bethany Baumbach, Paul Hwu, A. Sakkee, F. Ham, J. DeGroot, Ruud Bank, T. Keaveny (2005)
Trabecular microfracture and the influence of pyridinium and non-enzymatic glycation-mediated collagen cross-links.Bone, 37 6
D. Wolff (1870)
Ueber die innere Architectur der Knochen und ihre Bedeutung für die Frage vom KnochenwachsthumArchiv für pathologische Anatomie und Physiologie und für klinische Medicin, 50
D. Hukins (1984)
Connective Tissue Matrix
W. Tong, M. Glimcher, J. Katz, Liisa Kuhn, S. Eppell (2003)
Size and Shape of Mineralites in Young Bovine Bone Measured by Atomic Force MicroscopyCalcified Tissue International, 72
T. Wess, I. Alberts, J. Hiller, M. Drakopoulos, A. Chamberlain, M. Collins (2002)
Microfocus Small Angle X-ray Scattering Reveals Structural Features in Archaeological Bone Samples; Detection of Changes in Bone Mineral Habit and SizeCalcified Tissue International, 70
E. Lau, Colin Cooper (1996)
The epidemiology of osteoporosis. The oriental perspective in a world context.Clinical orthopaedics and related research, 323
W. Landis, K. Hodgens, J. Arena, M. Song, B. McEwen (1996)
Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomographyMicroscopy Research and Technique, 33
E. Seeman, B. Vellas, C. Benhamou, Jean Aquino, J. Semler, J. Kaufman, K. Hoszowski, A. Varela, C. Fiore, K. Brixen, J. Reginster, S. Boonen (2006)
Strontium Ranelate Reduces the Risk of Vertebral and Nonvertebral Fractures in Women Eighty Years of Age and OlderJournal of Bone and Mineral Research, 21
M. Yamauchi, D. Woodley, G. Mechanic (1988)
Aging and cross-linking of skin collagen.Biochemical and biophysical research communications, 152 2
S. Viguet-Carrin, P. Garnero, P. Delmas (2005)
The role of collagen in bone strengthOsteoporosis International, 17
A. Boskey, L. Spevak, E. Paschalis, S. Doty, M. McKee (2002)
Osteopontin Deficiency Increases Mineral Content and Mineral Crystallinity in Mouse BoneCalcified Tissue International, 71
M. Kazanci, P. Roschger, E. Paschalis, K. Klaushofer, P. Fratzl (2006)
Bone osteonal tissues by Raman spectral mapping: orientation-composition.Journal of structural biology, 156 3
V. Monnier, O. Bautista, D. Kenny, D. Sell, J. Fogarty, W. Dahms, P. Cleary, J. Lachin, S. Genuth (1999)
Skin collagen glycation, glycoxidation, and crosslinking are lower in subjects with long-term intensive versus conventional therapy of type 1 diabetes: relevance of glycated collagen products versus HbA1c as markers of diabetic complications. DCCT Skin Collagen Ancillary Study Group. Diabetes ControDiabetes, 48 4
S. Vasan, P. Foiles, H. Founds (2003)
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks.Archives of biochemistry and biophysics, 419 1
Z. Peng, J. Tuukkanen, H. Zhang, T. Jämsä, H. Väänänen (1994)
The mechanical strength of bone in different rat models of experimental osteoporosis.Bone, 15 5
Y. Miyamoto, W. Kaysser, B. Rabin, A. Kawasaki, R. Ford (1999)
Lessons from Nature
Y. Fu, C. Zheng, H. Li (2000)
[The study on the anti-osteoporosis effect of clodronate in ovariectomized rats].Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao, 31 2
J. Kanis, O. Johnell, A. Odén, A. Dawson, C. Laet, B. Jönsson (2001)
Ten Year Probabilities of Osteoporotic Fractures According to BMD and Diagnostic ThresholdsOsteoporosis International, 12
K. Nakamura, Y. Nakazawa, K. Ienaga (1997)
Acid-stable fluorescent advanced glycation end products: vesperlysines A, B, and C are formed as crosslinked products in the Maillard reaction between lysine or proteins with glucose.Biochemical and biophysical research communications, 232 1
P. Frasca, R. Harper, J. Katz (1977)
Collagen fiber orientations in human secondary osteons.Acta anatomica, 98 1
A.J Bailey, T. Sims, E. Ebbesen, J.P Mansell, J.S Thomsen, L. Mosekilde (1999)
Age-Related Changes in the Biochemical Properties of Human Cancellous Bone Collagen: Relationship to Bone StrengthCalcified Tissue International, 65
Helen Gruber, Harvey Gonick, F. Khalil-Manesh, Sanchez Tv, S. Motsinger, M. Meyer, Sharp Cf (1997)
Osteopenia induced by long-term, low- and high-level exposure of the adult rat to lead.Mineral and electrolyte metabolism, 23 2
R. Balena, B. Toolan, M. Shea, A. Markatos, E. Myers, S. Lee, E. Opas, J., G. Seedor, H. Klein, D. Frankenfield, H. Quartuccio, C. Fioravanti, Clair, E. Brown, W., C. Hayes, A. G., Rodan (1993)
The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates.The Journal of clinical investigation, 92 6
P. Meunier, J. Sebert, J. Reginster, D. Briançon, T. Appelboom, P. Netter, G. Loeb, A. Rouillon, S. Barry, J. Evreux, B. Avouac, X. Marchandise, The Group (1998)
Fluoride Salts are no Better at Preventing New Vertebral Fractures than Calcium-Vitamin D in Postmenopausal Osteoporosis: The FAVOStudyOsteoporosis International, 8
G. Fountos, E. Kounadi, M. Tzaphlidou, S. Yasumura, D. Glaros (1998)
The effects of inflammation-mediated osteoporosis (IMO) on the skeletal Ca/P ratio and on the structure of rabbit bone and skin collagen.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 49 5-6
A. Bailey, R. Paul, L. Knott (1998)
Mechanisms of maturation and ageing of collagenMechanisms of Ageing and Development, 106
D. Burr (2005)
Does early PTH treatment compromise bone strength? The balance between remodeling, porosity, bone mineral, and bone sizeCurrent Osteoporosis Reports, 3
M. Gambacciani, A. Spinetti, F. Taponeco, L. Piaggesi, B. Cappagli, M. Ciaponi, L. Rovati, A. Genazzani (2005)
Treatment of postmenopausal vertebral osteopenia with monofluorophospate: A long-term calcium-controlled studyOsteoporosis International, 5
S. Hengsberger, A. Kulik, P. Zysset (2002)
Nanoindentation discriminates the elastic properties of individual human bone lamellae under dry and physiological conditions.Bone, 30 1
D. Eyre (1987)
[7] Collagen cross-linking amino acidsMethods in Enzymology, 144
M. Rubin, I. Jasiuk (2005)
The TEM characterization of the lamellar structure of osteoporotic human trabecular bone.Micron, 36 7-8
L. Ameye, M. Young (2002)
Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases.Glycobiology, 12 9
S. Gadeleta, A. Boskey, E. Paschalis, C. Carlson, F. Menschik, T. Baldini, Margaret Peterson, C. Rimnac (2000)
A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis).Bone, 27 4
W. Landis (1995)
The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix.Bone, 16 5
D Eyre, I Dickson, K. Ness (1988)
Collagen cross-linking in human bone and articular cartilage. Age-related changes in the content of mature hydroxypyridinium residues.The Biochemical journal, 252 2
DM Black, SR Cummings, DB Karpf (1996)
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research GroupLancet, 348
N. Camacho, S. Rinnerthaler, E. Paschalis, R. Mendelsohn, A. Boskey, P. Fratzl (1999)
Complementary information on bone ultrastructure from scanning small angle X-ray scattering and Fourier-transform infrared microspectroscopy.Bone, 25 3
S. Yamagishi, M. Takeuchi, Y. Inagaki, Kei-ichiro Nakamura, T. Imaizumi (2003)
Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy.International journal of clinical pharmacology research, 23 4
G. Ramachandran, A. Reddi (1976)
Biochemistry of collagen
L. Callahan (1998)
The burden of rheumatoid arthritis: facts and figures.The Journal of rheumatology. Supplement, 53
A. Arsenault (1988)
Crystal-collagen relationships in calcified turkey leg tendons visualized by selected-area dark field electron microscopyCalcified Tissue International, 43
V. Monnier (1989)
Toward a Maillard reaction theory of aging.Progress in clinical and biological research, 304
K. Lau, J. Farley, T. Freeman, D. Baylink (1989)
A proposed mechanism of the mitogenic action of fluoride on bone cells: inhibition of the activity of an osteoblastic acid phosphatase.Metabolism: clinical and experimental, 38 9
G. Ross (2004)
Phosphates: Geochemical, Geobiological and Materials ImportanceGeoscience Canada, 31
M. Brownlee, A. Cerami, H. Vlassara (1988)
Advanced glycosylation end products in tissue and the biochemical basis of diabetic complications.The New England journal of medicine, 318 20
Lisa Miller, V. Vairavamurthy, Mark Chance, Richard Mendelsohn, E. Paschalis, Foster Betts, Adele Boskey (2001)
In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibration.Biochimica et biophysica acta, 1527 1-2
A. Friedman (2006)
Important Determinants of Bone Strength: Beyond Bone Mineral DensityJCR: Journal of Clinical Rheumatology, 12
R. Mccalden, J McGeough, M Barker, C. Court-Brown (1993)
Age-related changes in the tensile properties of cortical bone. The relative importance of changes in porosity, mineralization, and microstructure.The Journal of bone and joint surgery. American volume, 75 8
M. Tzaphlidou, H. Kafantari (2000)
Influence of nutritional factors on bone collagen fibrils in ovariectomized rats.Bone, 27 5
P. Fratzl, P. Roschger, J. Eschberger, B. Abendroth, K. Klaushofer (1994)
Abnormal bone mineralization after fluoride treatment in osteoporosis: A small‐angle x‐ray‐scattering studyJournal of Bone and Mineral Research, 9
Mitsuru Saito, Satoshi Mori, T. Mashiba, S. Komatsubara, K. Marumo (2008)
Collagen maturity, glycation induced-pentosidine, and mineralization are increased following 3-year treatment with incadronate in dogsOsteoporosis International, 19
T. Hassenkam, G. Fantner, Jacquelin Cutroni, J. Weaver, D. Morse, P. Hansma (2004)
High-resolution AFM imaging of intact and fractured trabecular bone.Bone, 35 1
N. Loveridge, J. Power, J. Reeve, A. Boyde (2004)
Bone mineralization density and femoral neck fragility.Bone, 35 4
S. Jackson, A. Cartwright, David Lewis (1978)
The morphology of bone mineral crystalsCalcified Tissue Research, 25
J. Skedros, K. Hunt (2004)
Does the degree of laminarity correlate with site‐specific differences in collagen fibre orientation in primary bone? An evaluation in the turkey ulna diaphysisJournal of Anatomy, 205
Huajian Gao, B. Ji, I. Jäger, E. Arzt, P. Fratzl (2003)
Materials become insensitive to flaws at nanoscale: Lessons from natureProceedings of the National Academy of Sciences of the United States of America, 100
P. Hester, M. Schreiweis, J. Orban, H. Mazzuco, M. Kopka, M. Ledur, D. Moody (2004)
Assessing bone mineral density in vivo: dual energy X-ray absorptiometry.Poultry science, 83 2
(1988)
Crosslinking and new
J. Rho, Peter Zioupos, J. Currey, G. Pharr (1999)
Variations in the individual thick lamellar properties within osteons by nanoindentation.Bone, 25 3
Tianshun Xu, P. Bianco, L. Fisher, G. Longenecker, Erica Smith, S. Goldstein, J. Bonadio, A. Boskey, A. Heegaard, B. Sommer, K. Satomura, P. Domínguez, Chengyang Zhao, A. Kulkarni, P. Robey, M. Young (1998)
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in miceNature Genetics, 20
William Landis, Janet Moradian-Oldak, Stephen Weiner (1991)
Topographic imaging of mineral and collagen in the calcifying turkey tendon.Connective tissue research, 25 3-4
Y. Katayama, T. Akatsu, M. Yamamoto, N. Kugai, N. Nagata (1996)
Role of nonenzymatic glycosylation of type I collagen in diabetic osteopeniaJournal of Bone and Mineral Research, 11
D. Vashishth (2007)
The role of the collagen matrix in skeletal fragilityCurrent Osteoporosis Reports, 5
A. Bailey, L. Knott (1999)
Molecular changes in bone collagen in osteoporosis and osteoarthritis in the elderlyExperimental Gerontology, 34
(2000)
tissue : a quantitative microradio - graphic analysis in postmenopausal women
Mitsuru Saito, K. Marumo, K. Fujii, Noriaki Ishioka (1997)
Single-column high-performance liquid chromatographic-fluorescence detection of immature, mature, and senescent cross-links of collagen.Analytical biochemistry, 253 1
JC Elliott (2002)
Calcium phosphate biominerals. Phosphates: Geochemical, Geobiological, and Materials ImportanceRev Mineral Geochem, 48
B. Wopenka, J. Pasteris (2005)
A mineralogical perspective on the apatite in boneMaterials Science and Engineering: C, 25
A. Honda, Y. Umemura, S. Nagasawa (2001)
Effect of High‐Impact and Low‐Repetition Training on Bones in Ovariectomized RatsJournal of Bone and Mineral Research, 16
H. Gupta, Jong Seto, W. Wagermaier, P. Zaslansky, P. Boesecke, P. Fratzl (2006)
Cooperative deformation of mineral and collagen in bone at the nanoscaleProceedings of the National Academy of Sciences, 103
A. Stewart, R. Cain, D. Burr, D. Jacob, C. Turner, J. Hock, M. Drezner (2000)
Six‐Month Daily Administration of Parathyroid Hormone and Parathyroid Hormone—Related Protein Peptides to Adult Ovariectomized Rats Markedly Enhances Bone Mass and Biomechanical Properties: A Comparison of Human Parathyroid Hormone 1–34, Parathyroid Hormone‐Related Protein 1–36, and SDZ‐ParathyroidJournal of Bone and Mineral Research, 15
T. Ciarelli, D. Fyhrie, A. Parfitt (2003)
Effects of vertebral bone fragility and bone formation rate on the mineralization levels of cancellous bone from white females.Bone, 32 3
G. Hein, C. Weiss, G. Lehmann, T. Niwa, G. Stein, S. Franke (2005)
Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findingsAnnals of the Rheumatic Diseases, 65
D. Nelson, J. Featherstone, J. Duncan, T. Cutress (1983)
Effect of carbonate and fluoride on the dissolution behaviour of synthetic apatites.Caries research, 17 3
M. Rubin, I. Jasiuk, Jeannette Taylor, J. Rubin, T. Ganey, R. Apkarian (2003)
TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone.Bone, 33 3
E. Paschalis, E. Shane, G. Lyritis, G. Skarantavos, R. Mendelsohn, A. Boskey (2004)
Bone Fragility and Collagen Cross‐LinksJournal of Bone and Mineral Research, 19
Peter Zioupos, J. Currey, A. Hamer (1999)
The role of collagen in the declining mechanical properties of aging human cortical bone.Journal of biomedical materials research, 45 2
P. Ducy, C. Desbois, B. Boyce, G. Pinero, B. Story, C. Dunstan, Erica Smith, J. Bonadio, S. Goldstein, C. Gundberg, A. Bradley, G. Karsenty (1996)
Increased bone formation in osteocalcin-deficient miceNature, 382
C. Rubin, A. Turner, R. Müller, E. Mittra, K. McLeod, Wei Lin, Yi-Xian Qin (2002)
Quantity and Quality of Trabecular Bone in the Femur Are Enhanced by a Strongly Anabolic, Noninvasive Mechanical InterventionJournal of Bone and Mineral Research, 17
O. Barou, D. Valentín, L. Vico, Catherine Tirode, A. Barbier, C. Alexandre, M. Lafage-Proust (2002)
High-Resolution Three-Dimensional Micro-Computed Tomography Detects Bone Loss and Changes in Trabecular Architecture Early: Comparison with DEXA and Bone Histomorphometry in a Rat Model of Disuse OsteoporosisInvestigative Radiology, 37
D. Yue, Steven Colagiuri, A. Mcelduff, M. Silink (1993)
Diabetes Control and Complications TrialMedical Journal of Australia, 159
G. Boivin, P. Chavassieux, A. Santora, J. Yates, P. Meunier (2000)
Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women.Bone, 27 5
K. Rummery (1998)
Changes in primary health care policy: the implications for joint commissioning with social services.Health & social care in the community, 6 6
E. Simmons, K. Pritzker, M. Grynpas, M. Grynpas (1991)
Age‐related changes in the human femoral cortexJournal of Orthopaedic Research, 9
S. Eppell, W. Tong, J. Katz, Liisa Kuhn, M. Glimcher (2001)
Shape and size of isolated bone mineralites measured using atomic force microscopyJournal of Orthopaedic Research, 19
S. Schuit, M. Klift, A. Weel, C. Laet, H. Burger, E. Seeman, A. Hofman, A. Uitterlinden, J. Leeuwen, H. Pols (2004)
Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study.Bone, 34 1
R. Paul, A. Bailey (1996)
Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes.The international journal of biochemistry & cell biology, 28 12
A. Boyde, M. Hobdell (1968)
Scanning electron microscopy of lamellar boneZeitschrift für Zellforschung und Mikroskopische Anatomie, 93
M. Yamauchi, D. Young, G. Chandler, G. Mechanic (1988)
Cross-linking and new bone collagen synthesis in immobilized and recovering primate osteoporosis.Bone, 9 6
Matthew Allen, E. Gineyts, D. Leeming, David Burr, David Burr, Pierre Delmas (2008)
Bisphosphonates alter trabecular bone collagen cross-linking and isomerization in beagle dog vertebraOsteoporosis International, 19
J. Foldes, A. Parfitt, M. Shih, Rao Ds, M. Kleerekoper (1991)
Structural and geometric changes in iliac bone: Relationship to normal aging and osteoporosisJournal of Bone and Mineral Research, 6
K. Kozloff, A. Carden, C. Bergwitz, A. Forlino, T. Uveges, M. Morris, J. Marini, S. Goldstein (2004)
Brittle IV Mouse Model for Osteogenesis Imperfecta IV Demonstrates Postpubertal Adaptations to Improve Whole Bone StrengthJournal of Bone and Mineral Research, 19
(1998)
Spectroscopic determination of collagen cross-links at the ultrastructural level, and its application to osteoporosis
Peter Fratzl, S. Schreiber, A. Boyde (1996)
Characterization of bone mineral crystals in horse radius by small-angle X-ray scatteringCalcified Tissue International, 58
Vashishith (2005)
EFFECTS OF NON-ENZYMATIC GLYCATION ON CANCELLOUS BONE FRAGILITY
J. Nyman, A. Roy, Jerrod Tyler, Rae Acuna, Heather Gayle, Xiaodun Wang (2007)
Age‐related factors affecting the postyield energy dissipation of human cortical boneJournal of Orthopaedic Research, 25
A. Bailey, S. Wotton, T. Sims, P. Thompson (1992)
Post-translational modifications in the collagen of human osteoporotic femoral head.Biochemical and biophysical research communications, 185 3
S. Lees, D. Eyre, S. Barnard (1990)
BAPN dose dependence of mature crosslinking in bone matrix collagen of rabbit compact bone: corresponding variation of sonic velocity and equatorial diffraction spacing.Connective tissue research, 24 2
I. Giardino, D. Edelstein, M. Brownlee (1994)
Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.The Journal of clinical investigation, 94 1
D. Cullinane, T. Einhorn (2002)
Biomechanics of Bone
K. Ding, Zai-Zhao Wang, M. Hamrick, Zhong-Bin Deng, Li Zhou, Baolin Kang, Sheng-li Yan, J. She, D. Stern, C. Isales, Q. Mi (2006)
Disordered osteoclast formation in RAGE-deficient mouse establishes an essential role for RAGE in diabetes related bone loss.Biochemical and biophysical research communications, 340 4
Y. Takano, C. Turner, D. Burr (1996)
Mineral anisotropy in mineralized tissues is similar among species and mineral growth occurs independently of collagen orientation in rats: Results from acoustic velocity measurementsJournal of Bone and Mineral Research, 11
M. Fondrk, E. Bahniuk, D. Davy (1999)
A damage model for nonlinear tensile behavior of cortical bone.Journal of biomechanical engineering, 121 5
Jayashanger Ramasamy, O. Akkus (2007)
Local variations in the micromechanical properties of mouse femur: the involvement of collagen fiber orientation and mineralization.Journal of biomechanics, 40 4
C. Turner, J. Rho, Y. Takano, T. Tsui, G. Pharr (1999)
The elastic properties of trabecular and cortical bone tissues are similar: results from two microscopic measurement techniques.Journal of biomechanics, 32 4
R. Legeros, M. Tung (1983)
Chemical stability of carbonate- and fluoride-containing apatites.Caries research, 17 5
Adele Boskey, Timothy Wright, Robert Blank (1999)
Collagen and Bone StrengthJournal of Bone and Mineral Research, 14
M. Giraud‐Guille (1988)
Twisted plywood architecture of collagen fibrils in human compact bone osteonsCalcified Tissue International, 42
S. Harris, N. Watts, H. Genant, C. McKeever, T. Hangartner, Michael Keller, C. Chesnut, Jacques Brown, E. Eriksen, M. Hoseyni, D. Axelrod, P. Miller (1999)
Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.JAMA, 282 14
V. Monnier (2003)
Intervention against the Maillard reaction in vivo.Archives of biochemistry and biophysics, 419 1
O. Akkus, Anna Polyakova-Akkus, F. Adar, M. Schaffler (2003)
Aging of Microstructural Compartments in Human Compact BoneJournal of Bone and Mineral Research, 18
J. Puzas, M. Sickel, M. Felter (1992)
Osteoblasts and chondrocytes are important target cells for the toxic effects of lead.Neurotoxicology, 13 4
S. Viguet-Carrin, J. Roux, M. Arlot, Z. Merabet, D. Leeming, I. Byrjalsen, P. Delmas, M. Bouxsein (2006)
Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae.Bone, 39 5
S. Bumrerraj, J. Katz (2001)
Scanning Acoustic Microscopy Study of Human Cortical and Trabecular BoneAnnals of Biomedical Engineering, 29
B Wopenka, JD Pasteris (2005)
A mineralogical perspective on the apatite in boneMat Sci Eng C-Biomim, 25
T Wess, I Alberts, J Hiller (2002)
Microfocus small angle X-ray scattering reveals structural features in archaeological bone samples: detection of changes in bone mineral habit and sizeCalcif Tissue Int, 70
P. Fratzl, H. Gupta, E. Paschalis, P. Roschger (2004)
Structure and mechanical quality of the collagen–mineral nano-composite in boneJournal of Materials Chemistry, 14
C. Danielsen, T. Andreassen, L. Mosekilde (1986)
Mechanical properties of collagen from decalcified rat femur in relation to age andin vitro maturationCalcified Tissue International, 39
R. Nagaraj, M. Prabhakaram, B. Ortwerth, V. Monnier (1994)
Suppression of Pentosidine Formation in Galactosemic Rat Lens by an Inhibitor of Aldose ReductaseDiabetes, 43
G. Long, J. Rosen, J. Pounds (1990)
Cellular lead toxicity and metabolism in primary and clonal osteoblastic bone cells.Toxicology and applied pharmacology, 102 2
Xiaodun Wang, Xinmei Shen, Xiaoe Li, C. Agrawal (2002)
Age-related changes in the collagen network and toughness of bone.Bone, 31 1
X. Banse, T. Sims, Allen Bailey (2002)
Mechanical Properties of Adult Vertebral Cancellous Bone: Correlation With Collagen Intermolecular Cross‐LinksJournal of Bone and Mineral Research, 17
S. Rinnerthaler, P. Roschger, H. Jakob, A. Nader, Klaus Klaushofer, Peter Fratzl (1999)
Scanning Small Angle X-ray Scattering Analysis of Human Bone SectionsCalcified Tissue International, 64
Cyrus Cooper, L.Joseph Melton (1992)
Epidemiology of osteoporosisTrends in Endocrinology & Metabolism, 3
H. Vlassara, R. Bucala, L. Striker (1994)
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.Laboratory investigation; a journal of technical methods and pathology, 70 2
D. Prockop, R. Berg, K. Kivirikko, J. Uitto (1976)
Intracellular Steps in the Biosynthesis of Collagen
Á. Escribano, M. Revilla, E. Hernández, C. Seco, J. González-Riola, L. Villa, H. Rico (1997)
Effect of Lead on Bone Development and Bone Mass: A Morphometric, Densitometric, and Histomorphometric Study in Growing RatsCalcified Tissue International, 60
T. Asefa, Chiaki Yoshina-Ishii, M. MacLachlan, G. Ozin (2000)
New nanocomposites: putting organic function 'inside' the channel walls of periodic mesoporous silicaJournal of Materials Chemistry, 10
Christopher Hernandez, Christopher Hernandez, G. Beaupré, G. Beaupré, T. Keller, D. Carter, D. Carter (2001)
The influence of bone volume fraction and ash fraction on bone strength and modulus.Bone, 29 1
P. Roschger, S. Rinnerthaler, J. Yates, G. Rodan, P. Fratzl, K. Klaushofer (2001)
Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women.Bone, 29 2
J. Huuskonen, I. Arnala, H. Olkkonen, E. Alhava (2001)
Alendronate influences bending force of femoral diaphysis after orchidectomy in rats.Annales chirurgiae et gynaecologiae, 90 2
R. Loeser, R. Yammani, C. Carlson, Hong Chen, A. Cole, H. Im, Laura Bursch, S. Yan (2005)
Articular chondrocytes express the receptor for advanced glycation end products: Potential role in osteoarthritis.Arthritis and rheumatism, 52 8
A. Corsi, T. Xu, X. Chen, A. Boyde, J. Liang, M. Mankani, B. Sommer, R. Iozzo, I. Eichstetter, P. Robey, P. Bianco, M. Young (2002)
Phenotypic Effects of Biglycan Deficiency Are Linked to Collagen Fibril Abnormalities, Are Synergized by Decorin Deficiency, and Mimic Ehlers‐Danlos‐Like Changes in Bone and Other Connective TissuesJournal of Bone and Mineral Research, 17
K. Bell, N. Loveridge, J. Power, N. Garrahan, M. Stanton, M. Lunt, B. Meggitt, J. Reeve (1999)
Structure of the Femoral Neck in Hip Fracture: Cortical Bone Loss in the Inferoanterior to Superoposterior AxisJournal of Bone and Mineral Research, 14
David Thompson, Aaron Posner, William Laughlin, N. Blumenthal (1983)
Comparison of bone apatite in osteoporotic and normal EskimosCalcified Tissue International, 35
S. Robins, J. Brady (2008)
Collagen Cross-Linking and Metabolism
H. Ritzel, M. Amling, M. Pösl, M. Hahn, G. Delling (1997)
The Thickness of Human Vertebral Cortical Bone and its Changes in Aging and Osteoporosis: A Histomorphometric Analysis of the Complete Spinal Column from Thirty‐Seven Autopsy SpecimensJournal of Bone and Mineral Research, 12
R. Bank, M. Bayliss, F. Lafeber, A. Maroudas, J. Tekoppele (1998)
Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage.The Biochemical journal, 330 ( Pt 1)
K. Hasegawa, C. Turner, D. Burr (1994)
Contribution of collagen and mineral to the elastic anisotropy of boneCalcified Tissue International, 55
S. Gadaleta, E. Paschalis, F. Betts, Richard Mendelsohn, A. Boskey (2006)
Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: New correlations between X-ray diffraction and infrared dataCalcified Tissue International, 58
L. Miller, William Little, A. Schirmer, Farhan Sheik, B. Busa, S. Judex (2007)
Accretion of Bone Quantity and Quality in the Developing Mouse SkeletonJournal of Bone and Mineral Research, 22
E. Donnelly, S. Baker, A. Boskey, M. Meulen (2006)
Effects of surface roughness and maximum load on the mechanical properties of cancellous bone measured by nanoindentation.Journal of biomedical materials research. Part A, 77 2
L. Fisher, M. Drum, P. Robey, K. Conn, J. Termine (1987)
Osteonectin content in human osteogenesis imperfecta bone shows a range similar to that of two bovine models of OICalcified Tissue International, 40
P. Garnero, O. Borel, E. Gineyts, F. Duboeuf, H. Solberg, M. Bouxsein, C. Christiansen, P. Delmas (2006)
Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone.Bone, 38 3
P. Fratzl, N. Fratzl-Zelman, K. Klaushofer, G. Vogl, K. Koller (1991)
Nucleation and growth of mineral crystals in bone studied by small-angle X-ray scatteringCalcified Tissue International, 48
J. Reginster, E. Seeman, M. Vernejoul, S. Adami, J. Compston, C. Phenekos, J. Devogelaer, M. Curiel, A. Sawicki, S. Goemaere, O. Sørensen, D. Felsenberg, P. Meunier (2005)
Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.The Journal of clinical endocrinology and metabolism, 90 5
M. McClung (1999)
Therapy for fracture prevention.JAMA, 282 7
T. Dowd, J. Rosen, R. Gupta (1990)
31P NMR and saturation transfer studies of the effect of Pb2+ on cultured osteoblastic bone cells.The Journal of biological chemistry, 265 34
K. Gross, C. Berndt (2002)
Biomedical Application of ApatitesReviews in Mineralogy & Geochemistry, 48
H. Kafantari, E. Kounadi, M. Fatouros, M. Milonakis, M. Tzaphlidou (2000)
Structural alterations in rat skin and bone collagen fibrils induced by ovariectomy.Bone, 26 4
S. Yamagishi, Kazuo Nakamura, T. Imaizumi (2005)
Advanced glycation end products (AGEs) and diabetic vascular complications.Current diabetes reviews, 1 1
D. Haguenauer, V. Welch, B. Shea, P. Tugwell, J. Adachi, G. Wells (2000)
Fluoride for the Treatment of Postmenopausal Osteoporotic Fractures: A Meta-AnalysisOsteoporosis International, 11
X. Guo, S. Goldstein (2000)
Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized ratsJournal of Orthopaedic Research, 18
R. Martin, J. Ishida (1989)
The relative effects of collagen fiber orientation, porosity, density, and mineralization on bone strength.Journal of biomechanics, 22 5
T. Miyahara, H. Komiyama, A. Miyanishi, M. Matsumoto, W. Xue-ya, M. Takata, S. Takata, M. Nagai, H. Kozuka, K. Yokoyama, Y. Kanamoto (1994)
Effects of lead on osteoclast-like cell formation in mouse bone marrow cell culturesCalcified Tissue International, 54
K. Nakanishi, N. Berova (1998)
Lessons from NatureCHIMIA
E. Eriksen, L. Mosekilde, F. Melsen (1985)
Effect of sodium fluoride, calcium, phosphate, and vitamin D2 on trabecular bone balance and remodeling in osteoporotics.Bone, 6 5
L. McNamara, A. Ederveen, C. Lyons, Colles Price, Mitchell Schaffler, Harrie Weinans, P. Prendergast (2006)
Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing.Bone, 39 2
G. Marotti, M. Muglia (1988)
A scanning electron microscope study of human bony lamellae. Proposal for a new model of collagen lamellar organization.Archivio italiano di anatomia e di embriologia. Italian journal of anatomy and embryology, 93 3
P. Zysset, X. Guo, C. Hoffler, K. Moore, S. Goldstein (1998)
Mechanical properties of human trabecular bone lamellae quantified by nanoindentation.Technology and health care : official journal of the European Society for Engineering and Medicine, 6 5-6
J. Termine, H. Kleinman, S. Whitson, K. Conn, M. McGarvey, G. Martin (1981)
Osteonectin, a bone-specific protein linking mineral to collagenCell, 26
J. Rho, T. Tsui, G. Pharr (1997)
Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation.Biomaterials, 18 20
J. Skedros, M. Dayton, Christian Sybrowsky, R. Bloebaum, K. Bachus (2006)
The influence of collagen fiber orientation and other histocompositional characteristics on the mechanical properties of equine cortical boneJournal of Experimental Biology, 209
M. Kleerekoper (1998)
The role of fluoride in the prevention of osteoporosis.Endocrinology and metabolism clinics of North America, 27 2
H. Pols, D. Felsenberg, D. Hanley, J. Stepan, M. Muñoz-Torres, T. Wilkin, G. Qin-sheng, A. Galich, K. Vandormael, A. Yates, B. Stych, for group (1999)
Multinational, Placebo-Controlled, Randomized Trial of the Effects of Alendronate on Bone Density and Fracture Risk in Postmenopausal Women with Low Bone Mass: Results of the FOSIT StudyOsteoporosis International, 9
E. Adachi, I. Hopkinson, I. Hopkinson, Toshihiko Hayashi (1997)
Basement-membrane stromal relationships: interactions between collagen fibrils and the lamina densa.International review of cytology, 173
L. Siu, Hui, Charles, W. Slemenda, C., Conrad Johnston (1988)
Age and bone mass as predictors of fracture in a prospective study.The Journal of clinical investigation, 81 6
J. Katz, Alain Meunier (1993)
Scanning acoustic microscope studies of the elastic properties of osteons and osteon lamellae.Journal of biomechanical engineering, 115 4B
I. Rapado, L. Shulman, H. Fleisch, P. Stern, C. Gennari, R. Morita, H. Genant, P. Burckhardt, C. Christiansen, W. Peck, E. Ogata, T. Martin, Luciano Martini (1993)
Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis.The American journal of medicine, 94 6
Hyun‐Man Kim, C. Rey, M. Glimcher (1995)
Isolation of calcium‐phosphate crystals of bone by non‐aqueous methods at low temperatureJournal of Bone and Mineral Research, 10
A. Burstein, J. Zika, K. Heiple, L. Klein (1975)
Contribution of collagen and mineral to the elastic-plastic properties of bone.The Journal of bone and joint surgery. American volume, 57 7
S. Weiner, Wolfie Traub (1989)
Crystal size and organization in bone.Connective tissue research, 21 1-4
J. Kalmey, C. Lovejoy (2002)
Collagen fiber orientation in the femoral necks of apes and humans: do their histological structures reflect differences in locomotor loading?Bone, 31 2
Daniel Jaschouz, O. Paris, P. Roschger, Hae-Sook Hwang, P. Fratzl (2003)
Pole figure analysis of mineral nanoparticle orientation in individual trabecula of human vertebral boneJournal of Applied Crystallography, 36
(1984)
Molecular Organization in the collagen fibril
A. Boskey, S. Gadaleta, C. Gundberg, S. Doty, P. Ducy, G. Karsenty (1998)
Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin.Bone, 23 3
E. Kounadi, G. Fountos, M. Tzaphlidou (1998)
The influence of inflammation-mediated osteopenia (IMO) on the structure of rabbit bone and skin collagen fibrils.Connective tissue research, 37 1-2
B. Borah, E. Ritman, T. Dufresne, S. Jorgensen, Sheng Liu, J. Sacha, R. Phipps, R. Turner (2005)
The effect of risedronate on bone mineralization as measured by micro-computed tomography with synchrotron radiation: correlation to histomorphometric indices of turnover.Bone, 37 1
N. Johanson, M. Charlson, L. Cutignola, M. Neves, E. Dicarlo, P. Bullough (1993)
Femoral neck bone density. Direct measurement and histomorphometric validation.The Journal of arthroplasty, 8 6
J. Currey, K. Brear, Peter Zioupos (1997)
The effects of ageing and changes in mineral content in degrading the toughness of human femora.Journal of biomechanics, 29 2
M. Kohn, J. Rakovan, J. Hughes (2002)
Phosphates : Geochemical, Geobiological, and Materials Importance
J. Linden, J. Verhaar, H. Weinans (2001)
A Three‐Dimensional Simulation of Age‐Related Remodeling in Trabecular BoneJournal of Bone and Mineral Research, 16
Vivi Ziv, S. Weiner (1994)
Bone crystal sizes: a comparison of transmission electron microscopic and X-ray diffraction line width broadening techniques.Connective tissue research, 30 3
C. Marcott, R. Reeder, E. Paschalis, D. Tatakis, A. Boskey, R. Mendelsohn (1998)
Infrared microspectroscopic imaging of biomineralized tissues using a mercury-cadmium-telluride focal-plane array detector.Cellular and molecular biology, 44 1
A. Ascenzi, E. Bonucci, P. Generali, A. Ripamonti, N. Roveri (1979)
Orientation of apatite in single osteon samples as studied by pole figuresCalcified Tissue International, 29
Jianfeng Xu, D. Meyers, D. Freije, S. Isaacs, K. Wiley, D. Nusskern, C. Ewing, Eric Wilkens, P. Bujnovszky, G. Bova, P. Walsh, W. Isaacs, J. Schleutker, M. Matikainen, T. Tammela, T. Visakorpi, O. Kallioniemi, R. Berry, D. Schaid, A. French, S. McDonnell, J. Schroeder, M. Blute, S. Thibodeau, H. Grönberg, M. Emanuelsson, J. Damber, A. Bergh, B. Jonsson, Jeffrey Smith, J. Bailey-Wilson, J. Carpten, D. Stephan, E. Gillanders, I. Amundson, T. Kainu, D. Freas‐Lutz, A. Baffoe-Bonnie, Anne Aucken, R. Sood, F. Collins, M. Brownstein, J. Trent (1998)
Evidence for a prostate cancer susceptibility locus on the X chromosome.Nature Genetics, 20
HA Pols, D Felsenberg, DA Hanley (1999)
Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study GroupOsteoporos Int, 9
Matthew Silva, M. Brodt, Z. Fan, J. Rho (2004)
Nanoindentation and whole-bone bending estimates of material properties in bones from the senescence accelerated mouse SAMP6.Journal of biomechanics, 37 11
L. Knott, A. Bailey (1998)
Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance.Bone, 22 3
H. Oxlund, Li. Sekilde, G. Ørtoft (1996)
Reduced concentration of collagen reducible cross links in human trabecular bone with respect to age and osteoporosis.Bone, 19 5
H. Oxlund, M. Barckman, G. Ørtoft, T. Andreassen (1995)
Reduced concentrations of collagen cross-links are associated with reduced strength of bone.Bone, 17 4 Suppl
J. Burnell, D. Baylink, C. Chestnut, M. Mathews, E. Teubner (1982)
Bone matrix and mineral abnormalities in postmenopausal osteoporosis.Metabolism: clinical and experimental, 31 11
B. Riggs, L. Melton (2002)
Bone Turnover Matters: The Raloxifene Treatment Paradox of Dramatic Decreases in Vertebral Fractures Without Commensurate Increases in Bone DensityJournal of Bone and Mineral Research, 17
K. Puustjärvi, J. Nieminen, T. Räsänen, M. Hyttinen, H. Helminen, H. Kröger, J. Huuskonen, E. Alhava, V. Kovanen (1999)
Do More Highly Organized Collagen Fibrils Increase Bone Mechanical Strength in Loss of Mineral Density After One‐Year Running Training?Journal of Bone and Mineral Research, 14
P. Meunier, Daniel Slosman, P. Delmas, J. Sebert, M. Brandi, Carlina Albanese, Roman Lorenc, S. Pors-Nielsen, M. Vernejoul, A. Roces, J. Reginster (2002)
Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial.The Journal of clinical endocrinology and metabolism, 87 5
K. Jepsen, M. Schaffler, J. Kuhn, R. Goulet, J. Bonadio, S. Goldstein (1997)
Type I collagen mutation alters the strength and fatigue behavior of Mov13 cortical tissue.Journal of biomechanics, 30 11-12
(2001)
A large proportion of fractures in postmenopausal women occur with baseline bone mineral density t-score −2.5
Bone mineral density is the gold-standard for assessing bone quantity and diagnosing osteoporosis. Although bone mineral density measurements assess the quantity of bone, the quality of the tissue is an important predictor of fragility. Understanding the macro- and nanoscale properties of bone is critical to understanding bone fragility in osteoporosis. Osteoporosis is a disease that affects more than 75 million people worldwide. The gold standard for osteoporosis prognosis, bone mineral density, primarily measures the quantity of bone in the skeleton, overlooking more subtle aspects of bone’s properties. Bone quality, a measure of bone’s architecture, geometry and material properties, is evaluated via mechanical, structural and chemical testing. Although decreased BMD indicates tissue fragility at the clinical level, changes in the substructure of bone can help indicate how bone quality is altered in osteoporosis. Additionally, mechanical properties which can quantify fragility, or bone’s inability to resist fracture, can be changed due to alterations in bone architecture and composition. Recent studies have focused on examination of bone on the nanoscale, suggesting the importance of understanding the interactions of the mineral crystals and collagen fibrils and how they can alter bone quality. It is therefore important to understand alterations in bone that occur at the macro-, micro- and nanoscopic levels to determine what parameters contribute to decreased bone quality in diseased tissue.
Osteoporosis International – Springer Journals
Published: Mar 4, 2008
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