Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Meyrick, L. Reid (1983)
Pulmonary hypertension. Anatomic and physiologic correlates.Clinics in chest medicine, 4 2
(1986)
A mAb against alpha-smooth muscle aetin: a new probe for smooth muscle differentiation
O. Skalli, M. Pelte, M. Peclet, G. Gabbiani, P. Gugliotta, G. Bussolati, M. Ravazzola, L. Orci (1989)
Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 37
A. Orlidge, Patr icia (1987)
Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cellsThe Journal of Cell Biology, 105
C. Kelley, P. D’Amore, H. Hechtman, D. Shepro (1987)
Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wallThe Journal of Cell Biology, 104
P. Nakane (1968)
SIMULTANEOUS LOCALIZATION OF MULTIPLE TISSUE ANTIGENS USING THE PEROXIDASE-LABELED ANTIBODY METHOD: A STUDY ON PITUITARY GLANDS OF THE RATJournal of Histochemistry and Cytochemistry, 16
I. Herman, P. D’Amore (1985)
Microvascular pericytes contain muscle and nonmuscle actinsThe Journal of Cell Biology, 101
T. Fujimoto, S. Singer (1987)
Immunocytochemical studies of desmin and vimentin in pericapillary cells of chicken.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35
N. Joyce, P. Decamilli, J. Boyles (1984)
Pericytes, like vascular smooth muscle cells, are immunocytochemically positive for cyclic GMP-dependent protein kinase.Microvascular research, 28 2
Omar Skalli, Joël Vandekerckhove, Giulio Gabbiani (1987)
Actin-isoform pattern as a marker of normal or pathological smooth-muscle and fibroblastic tissues.Differentiation; research in biological diversity, 33 3
D. Drenckhahn, U. Gröschel‐Stewart (1980)
Localization of myosin, actin, and tropomyosin in rat intestinal epithelium: immunohistochemical studies at the light and electron microscope levelsThe Journal of Cell Biology, 86
A. Antonelli-Orlidge, K. Saunders, Sandra Smith, P. D’Amore (1989)
An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.Proceedings of the National Academy of Sciences of the United States of America, 86 12
R. Chambers, B. Zweifach (1944)
Topography and function of the mesenteric capillary circulationAmerican Journal of Anatomy, 75
D. Larson, K. Fujiwara, R. Alexander, M. Gimbrone (1984)
Heterogeneity of myosin antigenic expression in vascular smooth muscle in vivo.Laboratory investigation; a journal of technical methods and pathology, 50 4
T. Kuwabara, D. Cogan (1963)
Retinal vascular patterns. VI. Mural cells of the retinal capillaries.Archives of ophthalmology, 69
T. Kuwabara, D. Cogan (1959)
TETRAZOLIUM STUDIES ON THE RETINA: I. INTRODUCTION AND TECHNIQUEJournal of Histochemistry and Cytochemistry, 7
(1922)
Beitriige zur Anatomic der Kapillaren: iiber kontraktile Elemente in der Gefal~wand der Blutkapillaren
D. Drenckhahn, J. Wagner (1986)
Stress fibers in the splenic sinus endothelium in situ: molecular structure, relationship to the extracellular matrix, and contractilityThe Journal of Cell Biology, 102
A. Guyton (1985)
Handbook of Physiology—The Cardiovascular SystemCritical Care Medicine, 13
D. Drenckhahn, R. Dermietzel (1988)
Organization of the actin filament cytoskeleton in the intestinal brush border: a quantitative and qualitative immunoelectron microscope studyThe Journal of Cell Biology, 107
Nancy Joyce, M. Haire, G. Palade, M. Haire (1985)
Contractile proteins in pericytes. II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrationsThe Journal of Cell Biology, 100
U. Gröschel‐Stewart, D. Drenckhahn (1982)
Muscular and Cytoplasmic Contractile ProteinsCollagen and related research, 2
Ulrike Tontsch, Hans-Christian Bauer (1989)
Isolation, characterization, and long-term cultivation of porcine and murine cerebral capillary endothelial cells.Microvascular research, 37 2
N. Joyce, M. Haire, G. Palade (1985)
Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosinThe Journal of Cell Biology, 100
R. Tilton, C. Kilo, J. Williamson, D. Murch (1979)
Differences in pericyte contractile function in rat cardiac and skeletal muscle microvasculatures.Microvascular research, 18 3
D. Cogan, T. Kuwabara (1960)
TETRAZOLIUM STUDIES ON THE RETINA: IV. DISTRIBUTION OF REDUCTASE IN OCULAR TISSUEJournal of Histochemistry and Cytochemistry, 8
G. Gabbiani, O. Kocher, W. Bloom, J. Vandekerckhove, K. Weber (1984)
Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media.The Journal of clinical investigation, 73 1
Microvascular pericytes are believed to be involved in various functions such as regulation of capillary blood flow and endothelial proliferation. Since pericytes represent a morphologically heterogeneous cell population ranging from circular smooth musclelike to elongated fibroblast-like morphology it is possible that regulation of blood flow (via contractility) and control of endothelial proliferation (as well as other metabolic functions) may be accomplished by different subsets of pericytes. In the present study we provide evidence for heterogeneity of pericytes at the molecular level by using two novel technical approaches. These are (a) immunostaining of whole mounts of the microvascular beds of the rat mesentery and bovine retina and (b) immunoblotting studies of microdissected retinal microvessels. We show that pericytes of true capillaries (midcapillaries) apparently lack the smooth muscle isoform of alpha-actin whereas transitional pericytes of pre- and postcapillary microvascular segments do express this isoform. Thus, regulation of capillary blood flow may be accomplished by the smooth muscle-related pre- and postcapillary pericytes whereas the nonmuscle pericytes of true capillaries may play a role in other functions.
The Journal of Cell Biology – Rockefeller University Press
Published: Apr 1, 1991
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.