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V. Cunningham, G. Sarna (1979)
ESTIMATION OF THE KINETIC PARAMETERS OF UNIDIRECTIONAL TRANSPORT ACROSS THE BLOOD‐BRAIN BARRIERJournal of Neurochemistry, 33
T. Moore, A. Lione, M. Sugden, D. Regen (1976)
Beta-hydroxybutyrate transport in rat brain: developmental and dietary modulations.The American journal of physiology, 230 3
W. Oldendorf (1971)
Blood brain barrier permeability to lactate.European neurology, 6 1
W. Pardridge, W. Oldendorf (1977)
TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER 1Journal of Neurochemistry, 28
Albrecht Betz, D. Gilboe, D. Yudilevich, L. Drewes (1973)
Kinetics of unidirectional glucose transport into the isolated dog brain.The American journal of physiology, 225 3
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M. Bradbury, C. Patlak, W. Oldendorf (1975)
Analysis of brain uptake and loss or radiotracers after intracarotid injection.The American journal of physiology, 229 4
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The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.The Biochemical journal, 142 3
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Sugar transport across the blood-brain barrier.The American journal of physiology, 219 5
L. Wade, R. Katzman (1975)
Rat brain regional uptake and decarboxylation of L-DOPA following carotid injection.The American journal of physiology, 228 2
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Rates of lactic acid permeation and utilization in the isolated dog brain.The American journal of physiology, 229 2
Jill Cremer, Jill Cremer, L. Braun, L. Braun, William Oldendorf, William Oldendorf (1976)
Changes during development in transport processes of the blood-brain barrier.Biochimica et biophysica acta, 448 4
Daniel Pm, Love Er, Pratt Oe (1978)
The effect of age upon the influx of glucose into the brain.The Journal of Physiology, 274
R. Wurtman, J. Fernstrom (1976)
Control of brain neurotransmitter synthesis by precursor availability and nutritional state.Biochemical pharmacology, 25 15
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Carbohydrate metabolism in fetal and neonatal rat brain during anoxia and recovery.The American journal of physiology, 230 5
C. Crone (1965)
Facilitated transfer of glucose from blood into brain tissue.The Journal of Physiology, 181
W. Pardridge, J. Connor, I. Crawford, W. Oldendorf (1975)
PEKMEABILITY CHANGES IN THE BLOOD-BRAIN BARRIER: CAUSES AND CONSEQUENCES*, 3
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Cerebral utilization of glucose, ketone bodies and oxygen in starving infant rats and the effect of intrauterine growth retardation.Acta physiologica Scandinavica, 98 2
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Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids.The American journal of physiology, 224 6
J. Fernstrom, D. Faller (1978)
NEUTRAL AMINO ACIDS IN THE BRAIN: CHANGES IN RESPONSE TO FOOD INGESTION 1Journal of Neurochemistry, 30
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The Pattern of Blood Lipids, Glycerol and Ketone Bodies during the Neonatal Period, Infancy and ChildhoodActa Pædiatrica, 55
W. Oldendorf, J. Szabo (1976)
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Albert Gjedde, Christian Crone (1975)
Induction processes in blood-brain transfer of ketone bodies during starvation.The American journal of physiology, 229 5
W. Pardridge, William Oldendorf (1975)
Kinetics of blood-brain transport of hexoses.Biochimica et biophysica acta, 382 3
T. Moore, A. Lione, D. Regen, H. Tarpley, P. Raines (1971)
Brain glucose metabolism in the newborn rat.The American journal of physiology, 221 6
William Oldendorf, William Oldendorf (1970)
Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard.Brain research, 24 2
W. Oldendorf (1971)
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection.The American journal of physiology, 221 6
R. Hawkins, D. Williamson, H. Krebs (1971)
Ketone-body utilization by adult and suckling rat brain in vivo.The Biochemical journal, 122 1
P. Daniel, E. Love, S. Moorhouse, O. Pratt (1977)
The transport of ketone bodies into the brain of the rat (in vivo)Journal of the Neurological Sciences, 34
H. Bachelard, Daniel Pm, Love Er, Pratt Oe (1973)
The transport of glucose into the brain of the rat in vivoProceedings of the Royal Society of London. Series B. Biological Sciences, 183
Daniel Daniel, Love Love, Pratt Pratt (1978)
The effect of age upon the influx of glucose into the brainJ. Physiol., Lond., 274
Persson Persson, Gentz Gentz (1966)
The pattern of blood lipids glycerol and ketone bodies during the neonatal period, infancy and childhoodActa paediat., 55
Abstract— The kinetics of the uptake from blood to brain of pyruvate, lactate and glucose have been determined in rats of different ages. The carotid artery single injection technique was used in animals anaesthetized with pentobarbital. The rates of influx for each substrate were determined over a range of concentrations for the different age‐groups. Data were analysed in terms of the Michaelis‐Menten equation with a component to allow for non‐saturable diffusion. Values are given for Km, Vmax and Kd. In suckling rats (15‐21 days) the Vmax values for both pyruvate and lactate were 2.0 μmol g−1 min−1. In 28‐day‐old rats the Vmax values had fallen to one‐half and in adults they were less than one‐tenth. Km, values were higher in the younger animals. The rate of glucose transport in suckling rats was half that of 28‐day‐old and adults although there was no difference with age in the Km values. The results are discussed in relation to the net flux of these substrates in and out of brain during different stages of post‐natal development.
Journal of Neurochemistry – Wiley
Published: Aug 1, 1979
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