Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/the-american-physiological-society/how-to-live-long-and-prosper-autophagy-mitochondria-and-aging-cf0mFN9lIX
References
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
- Publisher
- The American Physiological Society
- Copyright
- Copyright © 2011 the American Physiological Society
- ISSN
- 1548-9213
- eISSN
- 1548-9221
- DOI
- 10.1152/physiol.00013.2008
- pmid
- 18927201
- Publisher site
- See Article on Publisher Site
Abstract
Autophagy is a process of cellular self-degradation in which portions of the cytoplasm are sequestered within cytosolic double-membrane vesicles and delivered to the lysosome/vacuole. This process occurs in all eukaryotic cells and is partly a stress response; autophagy is induced during starvation and hypoxia. However, autophagy also plays a role during development and is associated with a range of diseases. Accumulating data also suggest the involvement of autophagy in aging. For example, the role of various hormones and nutrient sensing pathways in life span extension may involve autophagy. Similarly, autophagy is the primary mechanism for removing damaged organelles, such as mitochondria, which may have a direct impact on aging. Here, we review the role of autophagy, with an emphasis on the signaling pathways that are involved in regulation, and the consequences of autophagy induction with regard to aging.
Journal
Physiology – The American Physiological Society
Published: Oct 1, 2008