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Pancytopenia with severe thrombocytopenia in a patient treated with twice‐weekly LDL‐apheresis by polyacrylate adsorption from whole blood

Pancytopenia with severe thrombocytopenia in a patient treated with twice‐weekly LDL‐apheresis by... Pancytopenia with severe thrombocytopenia occurred in a patient treated with low‐density lipoprotein (LDL)‐apheresis by polyacrylate adsorption from whole blood, after treatment frequency had been increased from once to twice a week. Cell counts recovered with discontinuation of LDL‐apheresis, but thrombocytopenia recurred after resumption of twice‐weekly treatments. Thrombocyte counts remained stable following the replacement of polyacrylate adsorption from whole blood by double‐filtration plasmapheresis. The complications' close coincidence with twice‐weekly polyacrylate adsorption from whole blood suggests a causal relationship, although by a still unknown mechanism. Monitoring of thrombocytes should be advised in patients treated with LDL‐apheresis by polyacrylate adsorption from whole blood. J. Clin. Apheresis 2010. © 2010 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Apheresis Wiley

Pancytopenia with severe thrombocytopenia in a patient treated with twice‐weekly LDL‐apheresis by polyacrylate adsorption from whole blood

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References (8)

Publisher
Wiley
Copyright
Copyright © 2010 Wiley‐Liss, Inc.
ISSN
0733-2459
eISSN
1098-1101
DOI
10.1002/jca.20228
pmid
20101676
Publisher site
See Article on Publisher Site

Abstract

Pancytopenia with severe thrombocytopenia occurred in a patient treated with low‐density lipoprotein (LDL)‐apheresis by polyacrylate adsorption from whole blood, after treatment frequency had been increased from once to twice a week. Cell counts recovered with discontinuation of LDL‐apheresis, but thrombocytopenia recurred after resumption of twice‐weekly treatments. Thrombocyte counts remained stable following the replacement of polyacrylate adsorption from whole blood by double‐filtration plasmapheresis. The complications' close coincidence with twice‐weekly polyacrylate adsorption from whole blood suggests a causal relationship, although by a still unknown mechanism. Monitoring of thrombocytes should be advised in patients treated with LDL‐apheresis by polyacrylate adsorption from whole blood. J. Clin. Apheresis 2010. © 2010 Wiley‐Liss, Inc.

Journal

Journal of Clinical ApheresisWiley

Published: Jan 1, 2010

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