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Baumann Baumann (1989)
Hepatic acute phase reaction in vivo and in vitroIn vitro cellular and developmental biology, 25
R. Pauwels, J. Kips, R. Peleman, Marcel Straeten (1990)
The effect of endotoxin inhalation on airway responsiveness and cellular influx in rats.The American review of respiratory disease, 141 3
G. Richards, A. Theron, C. Merwe, R. Anderson (1989)
Spirometric abnormalities in young smokers correlate with increased chemiluminescence responses of activated blood phagocytes.The American review of respiratory disease, 139 1
A. Herbert, M. Carvalheiro, E. Rubenowitz, B. Bake, R. Rylander (1992)
Reduction of alveolar-capillary diffusion after inhalation of endotoxin in normal subjects.Chest, 102 4
Thornton Jc, A. Miller (1984)
Standardized lung function testing.Bulletin europeen de physiopathologie respiratoire, 20 6
T. Espevik, J. Nissen‐meyer (1986)
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes.Journal of immunological methods, 95 1
S. Marinkovic, G. Jahreis, G. Wong, Heinz Baumann (1989)
IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.Journal of immunology, 142 3
C. Nathan (1987)
Secretory products of macrophages.The Journal of clinical investigation, 79 2
Suffredini Suffredini, Shelhamer Shelhamer, Neumann Neumann (1992)
Pulmonary and oxygen effects of intravenously administered endotoxin in normal humansAm Rev Respir Dis, 145
I. Chapman, A. Foster, J. Morley (1993)
The relationship between inflammation and hyperreactivity of the airways in asthmaClinical & Experimental Allergy, 23
O. Michel, R. Ginanni, J. Duchateau, F. Vertongen, B. Bon, R. Sergysels (1991)
Domestic endotoxin exposure and clinical severity of asthmaClinical & Experimental Allergy, 21
H. Michie, K. Manogue, D. Spriggs, A. Revhaug, S. O'dwyer, C. Dinarello, A. Cerami, S. Wolff, D. Wilmore (1988)
Detection of circulating tumor necrosis factor after endotoxin administration.The New England journal of medicine, 318 23
Thomas Sandström, Leif Bjermer, R. Rylander (1992)
Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid.The European respiratory journal, 5 8
J. Athens, O. Haab, S. Raab, A. Mauer, H. Ashenbrucker, G. Cartwright, M. Wintrobe (1961)
Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects.The Journal of clinical investigation, 40
M. Lumpkin (1987)
The regulation of ACTH secretion by IL-1.Science, 238 4826
T. Lee, S. Lane (1992)
The role of macrophages in the mechanisms of airway inflammation in asthma.The American review of respiratory disease, 145 2 Pt 2
O. Michel, R. Ginanni, R. Sergysels (1992)
Relation between the bronchial obstructive response to inhaled lipopolysaccharide and bronchial responsiveness to histamine.Thorax, 47 4
O. Michel, R. Ginanni, Béatrice Bon, J. Content, J. Duchateau, R. Sergysels (1992)
Inflammatory response to acute inhalation of endotoxin in asthmatic patients.The American review of respiratory disease, 146 2
Steve Nelson, G. Bagby, B. Bainton, Lawrence Wilson, James Thompson, Warren Summer (1989)
Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response.The Journal of infectious diseases, 159 2
D. Heederik, R. Brouwer, K. Biersteker, J. Boleij (1991)
Relationship of airborne endotoxin and bacteria levels in pig farms with the lung function and respiratory symptoms of farmersInternational Archives of Occupational and Environmental Health, 62
Rylander Rylander, Fogelmark Fogelmark, Sjoslrand Sjoslrand (1985)
Free lung cell phagocytosis and lysosomal enzymes activity after inhalation of lipopolysaccharide in guinea‐pigsAgents Action, 16
Nadine Martinet, P. Vaillant, T. Charles, J. Lambert, Yves Martinet (1992)
Dexamethasone modulation of tumour necrosis factor-alpha (cachectin) release by activated normal human alveolar macrophages.The European respiratory journal, 5 1
J. Kips, Jan Tavernier, R. Pauwels (1992)
Tumor necrosis factor causes bronchial hyperresponsiveness in rats.The American review of respiratory disease, 145 2 Pt 1
K. Donham, P. Haglind, Y. Peterson, R. Rylander, L. Belin (1989)
Environmental and health studies of farm workers in Swedish swine confinement buildings.British Journal of Industrial Medicine, 46
A. Wardlaw, K. Chung, R. Moqbel, A. Macdonald, A. Hartnell, M. Mccusker, J. Collins, P. Barnes, A. Kay (1990)
Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness.The American review of respiratory disease, 141 2
S. Durham, M. Carroll, G. Walsh, A. Kay (1984)
Leukocyte activation in allergen-induced late-phase asthmatic reactions.The New England journal of medicine, 311 22
A. Halstensen, B. Haneberg, J. Glette, S. Sandberg, C. Solberg (1986)
Factors important for the measurement of chemiluminescence production by polymorphonuclear leukocytes.Journal of immunological methods, 88 1
R. Rylander, P. Haglind, M. Lundholm (1985)
Endotoxin in cotton dust and respiratory function decrement among cotton workers in an experimental cardroom.The American review of respiratory disease, 131 2
Athens Athens, Haab Haab, Raab Raab (1961)
The total blood circulating and marginal granulocytes pools and the granulocyte turnover rate in normal subjectsJ Clin Invest, 40
Lee Lee, Lane Lane (1992)
The role of macrophages in the mechanisms of airway inflammationAm Rev Respir Dis, 145
A. Suffredini, J. Shelhamer, R. Neumann, M. Brenner, R. Baltaro, J. Parrillo (1992)
Pulmonary and oxygen transport effects of intravenously administered endotoxin in normal humans.The American review of respiratory disease, 145 6
C. Muñoz, B. Misset, C. Fitting, J. Blériot, Jean‐Carlet, J. Cavaillon (1991)
Dissociation between plasma and monocyte‐associated cytokines during sepsisEuropean Journal of Immunology, 21
Olaf Michel, Jean Duchateau, R. Sergysels (1989)
Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects.Journal of applied physiology, 66 3
A. Vecchiarelli, Andrea Siracusa, E. Cenci, Manuela Puliti, Giuseppe Abbritti (1992)
Effect of corticosteroid treatment on interleukin‐1 and tumour necrosis factor secretion by monocytes from subjects with asthmaClinical & Experimental Allergy, 22
T. Smid, D. Heederik, R. Houba, P. Quanjer (1992)
Dust- and endotoxin-related respiratory effects in the animal feed industry.The American review of respiratory disease, 146 6
Wardlow Wardlow, Chung Chung, Moqbel Moqbel (1990)
Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophilsAm Rev Respir Dis, 141
R. Rylander, B. Bake, J. Fischer, I. Helander (1989)
Pulmonary function and symptoms after inhalation of endotoxin.The American review of respiratory disease, 140 4
Summary Previously we have reported that in asthmatics an inhalation of 20 μg lipopolysaccharide (LPS) produces a bronchial obstruction associated with an inflammatory blood response. The aim of the present study was to evaluate this response in normal subjects. Eight normal non‐atopic subjects were challenged by inhalation of a solution containing 20 μg LPS (from Escherichia coli 026:B6) a week after bronchial challenge with control solution. The lung function response was evaluated by the changes in forced expiratory volume in one second (FEV1), in specific conductance and in airway resistance while the blood inflammatory response was evaluated by serial measures of total white blood cells (WBC) and polymorphonuclear neutrophils (PMN) count, luminol enhanced‐chemiluminescence (luminol‐CL, as a marker of the PMN degree of activation), C‐reactive protein (CRP), haptoglobin, complement fraction C3, tumour necrosis factor‐α (TNF‐α) and adrenocorticotropic hormone (ACTH). No response in lung function was observed for 6 h after the LPS inhalation. The count in WBC and PMN increased 300 (P < 0.01) and 360 (P < 0.01) min after the LPS challenge associated with an increase in the level of luminol‐CL (P < 0.001). This rise in luminol‐CL level was significant at 120 min (P < 0.05) before any change in the PMN count. After 24 and 48 h the acute‐phase protein CRP raised significantly (P < 0.01), the other proteins C3 and haptoglobin being unchanged. A slight increase in ACTH was observed 240 and 360 min (P < 0.05) after the LPS challenge while the TNFα detectable level was not modified. In conclusion, in normal subjects, inhalation of a pro‐inflammatory agent is able to induce a systemic inflammatory response in the absence of any effect on lung mechanics, while in asthmatics the same bronchial challenge has been reported to induce a similar blood inflammation associated with a significant response in lung function.
Clinical & Experimental Allergy – Wiley
Published: Jan 1, 1995
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