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Hong Wang, V. Pickel (2001)
Preferential Cytoplasmic Localization of δ-Opioid Receptors in Rat Striatal Patches: Comparison with Plasmalemmal μ-Opioid ReceptorsThe Journal of Neuroscience, 21
J. Manzanares, J. Corchero, J. Romero, J. Fernández-Ruiz, J. Ramos, J. Fuentes (1999)
Pharmacological and biochemical interactions between opioids and cannabinoids.Trends in pharmacological sciences, 20 7
D. Hutcheson, E. Tzavara, C. Smadja, E. Valjent, B. Roques, J. Hanoune, R. Maldonado (1998)
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Δ‐9‐tetrahydrocannabinolBritish Journal of Pharmacology, 125
I. Gomes, Bryen Jordan, Achla Gupta, N. Trapaidze, Nagy, Lakshmi Devi (2000)
Heterodimerization of mu and delta opioid receptors: A role in opiate synergy.The Journal of neuroscience : the official journal of the Society for Neuroscience, 20 22
Miquel Martin, C. Ledent, M. Parmentier, R. Maldonado, O. Valverde (2000)
Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout miceEuropean Journal of Neuroscience, 12
J. Traynor, J. Elliott (1993)
δ-opioid receptor subtypes and cross-talk with μ-receptorsTrends in Pharmacological Sciences, 14
E. Gardner, J. Lowinson (1991)
Marijuana's interaction with brain reward systems: Update 1991Pharmacology Biochemistry and Behavior, 40
D. Filliol, S. Ghozland, J. Chluba, M. Martín, H. Matthes, F. Simonin, K. Befort, C. Gaveriaux-Ruff, A. Dierich, M. Lemeur, O. Valverde, R. Maldonado, B. Kieffer (2000)
Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.Nature genetics, 25 2
I. Gomes, Bryen Jordan, Achla Gupta, N. Trapaidze, V. Nagy, L. Devi (2000)
Heterodimerization of μ and δ Opioid Receptors: A Role in Opiate SynergyThe Journal of Neuroscience, 20
E. Valjent, Rafael Maldonado (2000)
A behavioural model to reveal place preference to Δ9-tetrahydrocannabinol in micePsychopharmacology, 147
Norman White, Noboru Hiroi, Noboru Hiroi (1998)
Preferential localization of self-stimulation sites in striosomes/patches in the rat striatum.Proceedings of the National Academy of Sciences of the United States of America, 95 11
F. Porreca, A. Takemori, M. Sultana, P. Portoghese, Wayne Bowen, H. Mosberg (1992)
Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors.The Journal of pharmacology and experimental therapeutics, 263 1
S. Ghozland, H. Matthes, F. Simonin, D. Filliol, B. Kieffer, R. Maldonado (2002)
Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid ReceptorsThe Journal of Neuroscience, 22
S. Munro, K. Thomas, Muna Abu-Shaar (1993)
Molecular characterization of a peripheral receptor for cannabinoidsNature, 365
ã Federation of European Neuroscience Societies
C. Ledent, O. Valverde, G. Cossu, F. Petitet, J. Aubert, F. Beslot, G. Böhme, A. Imperato, T. Pedrazzini, B. Roques, G. Vassart, W. Fratta, M. Parmentier (1999)
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.Science, 283 5400
G. Tanda, F. Pontieri, G. Chiara (1997)
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.Science, 276 5321
B. Kieffer (1999)
Opioids: first lessons from knockout mice.Trends in pharmacological sciences, 20 1
A. Ameri (1999)
The effects of cannabinoids on the brainProgress in Neurobiology, 58
E. Valjent, R. Maldonado (2000)
A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice.Psychopharmacology, 147 4
J. Traynor, J. Elliott (1993)
delta-Opioid receptor subtypes and cross-talk with mu-receptors.Trends in pharmacological sciences, 14 3
A. Bloom, W. Dewey (1978)
A comparison of some pharmacological actions of morphine and Δ9-tetrahydrocannabinol in the mousePsychopharmacology, 57
A. Lichtman, S. Sheikh, H. Loh, B. Martin (2001)
Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice.The Journal of pharmacology and experimental therapeutics, 298 3
I. Reche, J. Fuentes, M. Ruiz‐Gayo (1996)
Potentiation of Δ9-tetrahydrocannabinol-induced analgesia by morphine in mice: involvement of μ- and κ-opioid receptorsEuropean Journal of Pharmacology, 318
Janssen Pa, Niemegeers Cj, Dony Jg (1963)
The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats.Drug Research, 13
U. Arvidsson, M. Riedl, S. Chakrabarti, J. Lee, A. Nakano, R. Dado, H. Loh, P. Law, M. Wessendorf, R. Elde (1995)
Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord, 15
O. Valverde, F. Noble, F. Beslot, V. Daugé, M. Fournie-Zaluski, B. Roques (2001)
Δ9‐tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effectEuropean Journal of Neuroscience, 13
O. Valverde, R. Maldonado, E. Valjent, A. Zimmer, A. Zimmer (2000)
Cannabinoid Withdrawal Syndrome Is Reduced in Pre-Proenkephalin Knock-Out MiceThe Journal of Neuroscience, 20
D. Filliol, S. Ghozland, J. Chluba, Miguel Martín, H. Matthes, F. Simonin, K. Befort, C. Gaveriaux-Ruff, A. Dierich, M. Lemeur, O. Valverde, R. Maldonado, B. Kieffer (2000)
Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responsesNature Genetics, 25
F. Smith, K. Fujimori, J. Lowe, S. Welch (1998)
Characterization of Δ9-Tetrahydrocannabinol and Anandamide Antinociception in Nonarthritic and Arthritic RatsPharmacology Biochemistry and Behavior, 60
S. Thorat, H. Bhargava (1994)
Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice.European journal of pharmacology, 260 1
W. Devane, F. Dysarz, M. Johnson, L. Melvin, A. Howlett (1988)
Determination and characterization of a cannabinoid receptor in rat brain.Molecular pharmacology, 34 5
R. Maldonado, Adolfo Saiardi, O. Valverde, T. Samad, B. Roques, E. Borrelli (1997)
Absence of opiate rewarding effects in mice lacking dopamine D2 receptorsNature, 388
E. Abdelhamid, M. Sultana, P. Portoghese, A. Takemori (1991)
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.The Journal of pharmacology and experimental therapeutics, 258 1
S. Ghozland, H. Matthes, F. Simonin, D. Filliol, B. Kieffer, R. Maldonado (2002)
Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience, 22 3
M. Navarro, J. Chowen, M. Carrera, I. Arco, M. Villanúa, Yolanda Martin, A. Roberts, G. Koob, F. Fonseca (1998)
CB1 cannabinoid receptor antagonist‐induced opiate withdrawal in morphine‐dependent ratsNeuroReport, 9
David Rowen, J. Embrey, C. Moore, S. Welch (1998)
Antisense Oligodeoxynucleotides to the Kappa1 Receptor Enhance Δ9-THC–Induced Antinociceptive TolerancePharmacology Biochemistry and Behavior, 59
Several studies have shown a functional relationship between the endogenous cannabinoid and opioid systems. However, acute effects of Δ9‐tetrahydrocannabinol (THC) and physical dependence were not modified in knockout mice with single deletion of mu (MOR), delta (DOR) or kappa (KOR) opioid receptors. To further investigate the neurobiological basis of cannabinoid dependence, we have evaluated acute pharmacological responses, rewarding effects, tolerance and dependence to THC in double MOR/DOR knockout mice. Antinociception and hypolocomotion induced by acute THC administration remained unaffected, whereas the hypothermic effect was slightly attenuated in these double knockout mice. During chronic THC treatment, knockout mice developed slower tolerance to the hypothermic effect, but the development of tolerance to antinociceptive and hypolocomotor effects was unchanged. The rewarding properties of THC, measured in the conditioned place preference paradigm, were reduced in knockout mice. Interestingly, the somatic manifestations of THC withdrawal were also significantly attenuated in mutant mice, suggesting that a cooperative action of MOR and DOR is required for the entire expression of THC dependence.
European Journal of Neuroscience – Wiley
Published: Jan 1, 2003
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