Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Williamson, J. Neale (1988)
Calcium-dependent release ofN-acetylaspartylglutamate from retinal neurons upon depolarizationBrain Research, 475
R. Blakely, M. Robinson, Reid Thompson, J. Coyle (1988)
Hydrolysis of the Brain Dipeptide N‐Acetyl‐l‐Aspartyl‐l‐Glutamate: Subcellular and Regional Distribution, Ontogeny, and the Effect of Lesions on N‐Acetylated‐α‐Linked Acidic Dipeptidase ActivityJournal of Neurochemistry, 50
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
(1982)
EMG in motor neuron diseases. AAEE Minimono-graph Series No. 18
R. Zaczek, Kerry Koller, Robert Cotter, David Heller, Joseph Coyle (1983)
N-acetylaspartylglutamate: an endogenous peptide with high affinity for a brain "glutamate" receptor.Proceedings of the National Academy of Sciences of the United States of America, 80 4
L. Dzubow, D. Garfinkel (1970)
A simulation study of brain compartments. II. Atom-by-atom simulation of the metabolism of specifically labeled glucose and acetate.Brain research, 23 3
R. Rodnight (1983)
Schizophrenia: Some Current Neurochemical ApproachesJournal of Neurochemistry, 41
Kjell Fuxe, Peter Roberts, Robert Schwarcz (1983)
Excitotoxins
L. Williamson, J. Neale (1988)
Ultrastructural localization of N-acetylaspartylglutamate in synaptic vesicles of retinal neuronsBrain Research, 456
A. Plaitakis, W. Nicklas, R. Desnick (1980)
Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndromeAnnals of Neurology, 7
L. Hertz (1979)
Functional interactions between neurons and astrocytes I. Turnover and metabolism of putative amino acid transmittersProgress in Neurobiology, 13
P. Spencer, P. Nunn, P. Nunn, J. Hugon, J. Hugon, A. Ludolph, A. Ludolph, S. Ross, D. Roy, Richard Robertson (1987)
Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin.Science, 237 4814
J. Bernstein, R. Fisher, R. Zaczek, J. Coyle (1985)
Dipeptides of glutamate and aspartate may be endogenous neuroexcitants in the rat hippocampal slice, 5
J. Olney (1969)
Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium GlutamateScience, 164
Constantakakis Constantakakis, Plaitakis Plaitakis (1988)
N‐Acetylaspartate and N‐acetylaspartylglutamate are altered in the spinal cord in amyotrophic lateral sclerosisAnn Neurol, 24
L. Ory-Lavollée, R. Blakely, J. Coyle (1987)
Neurochemical and Immunocytochemical Studies on the Distribution of N‐Acetyl‐Aspartylglutamate and N‐Acetyl‐Aspartate in Rat Spinal Cord and Some Peripheral Nervous TissuesJournal of Neurochemistry, 48
J. Weiss, J. Koh, D. Choi (1989)
Neurotoxicity ofβ-N-methylamino-l-alanine (BMAA) andβ-N-oxalylamino-l-alamine (BOAA) on cultured cortical neuronsBrain Research, 497
M. Harrison, R. Fraser, B. Mullan (1961)
Calcium metabolism in osteoporosis. Acute and long-term responses to increased calcium intake.Lancet, 1 7185
N. Robinson (1968)
Chemical changes in the spinal cord in Friedreich's ataxia and motor neurone disease.Journal of Neurology, Neurosurgery & Psychiatry, 31
Joseph Martin (1984)
Huntington's diseaseNeurology, 34
J. Martin, J. Gusella (1986)
Huntington's disease. Pathogenesis and management.The New England journal of medicine, 315 20
C. Berg, D. Garfinkel (1971)
A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain.The Biochemical journal, 123 2
J. Rothstein, B. Tabakoff (1984)
Alteration of Striatal Glutamate Release After Glutamine Synthetase InhibitionJournal of Neurochemistry, 43
M. Favaron, H. Manev, H. Alho, M. Bertolino, B. Ferret, Alessandro Guidotti, Erminio Costa (1988)
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.Proceedings of the National Academy of Sciences of the United States of America, 85 19
Pappas Sc, Jones Ea (1983)
Methods for Assessing Hepatic EncephalopathySeminars in Liver Disease, 3
P. Divry, M. Mathieu (1989)
Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease.American journal of medical genetics, 32 4
Yoshino Yoshino, Koike Koike, Akaik Akaik (1979)
Free amino acids in motor neuron cortex in amyotrophic lateral sclerosisExperientia, 35
Rothstein Rothstein, Tabakoff Tabakoff (1985)
Glial and neuronal transport following glutamine synthetase inhibitionBiochem Pharmacol, 34
Kostic Kostic, Mojsilovic Mojsilovic, Stojanovic Stojanovic (1989)
Degenerative neurological disorders associated with a deficiency of glutamate dehydrogenaseJ Neurol, 236
A. Plaitakis, J. Caroscio (1987)
Abnormal glutamate metabolism in amyotrophic lateral sclerosisAnnals of Neurology, 22
M. Sande, Yves Mardens, K. Adriaenssens, A. Lowenthal (1970)
THE FREE AMINO ACIDS IN HUMAN CEREBROSPINAL FLUIDJournal of Neurochemistry, 17
S. Berl, D. Clarke (1978)
Metabolic Compartmentation of the Glutamate - Glutamine System: Glial Contribution
T. Perry, S. Hansen, Karen Jones (1987)
Brain glutamate deficiency in amyotrophic lateral sclerosisNeurology, 37
S. Rothman (1984)
Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, 4
W. Brain (1892)
Diseases of the Nervous SystemBuffalo Medical and Surgical Journal, 32
P. Macdonnell, O. Greengard (1975)
THE DISTRIBUTION OF GLUTAMATE DECARBOXYLASE IN RAT TISSUES; ISOTOPIC VS FLUORIMETRIC ASSAYSJournal of Neurochemistry, 24
T. Perry, S. Hansen, J. Kennedy (1975)
CSF amino acids and plasma‐CSF amino acid ratios in adults 1Journal of Neurochemistry, 24
Guarda Guarda, Robinson Robinson, Ory‐Lavollee Ory‐Lavollee (1988)
Quantitation of N‐acetyl‐aspartyl‐glutamate in microdissected brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassayMol Brain Res, 3
E. Barnard, E. Costa (1989)
Allosteric modulation of amino acid receptors : therapeutic implications
(1984)
Schousboe A
M. Robinson, R. Blakely, R. Couto, J. Coyle (1987)
Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.The Journal of biological chemistry, 262 30
T. Ferraro, T. Hare (1985)
Free and conjugated amino acids in human CSF: Influence of age and sexBrain Research, 338
H. Rosen, N. Yoshimura, Jane Hodgman, J. Fischer (1977)
Plasma amino acid patterns in hepatic encephalopathy of differing etiology.Gastroenterology, 72 3
P. Gillberg, S. Aquilonius, Sven-åke Eckerna¨s, G. Lundqvist, B. Winblad (1982)
Choline acetyltransferase and substance P-like immuno-reactivity in the human spinal cord: changes in amyotrophic lateral sclerosisBrain Research, 250
(1987)
Hydrolysis of the dipeptide N - acetyl - aspartyl - L - glutamate
Y. Nagata, M. Okuya, R. Watanabe, M. Honda (1982)
Regional distribution of cholinergic neurons in human spinal cord transections in the patients with and without motor neurons diseaseBrain Research, 244
G. Tsai, G. Forloni, M. Robinson, B. Stauch, J. Coyle (1988)
Calcium‐Dependent Evoked Release of N[3H]Acetylaspartylglutamate from the Optic PathwayJournal of Neurochemistry, 51
Kunihiro Iijima, Sadao Takase, Kenji Tsumuraya, Minoru Endo, K. Itahara (1978)
Changes in free amino acids of cerebrospinal fluid and plasma in various neurological diseases.The Tohoku journal of experimental medicine, 126 2
B. Patten, Y. Harati, Luis Acosta, Shin-siung Jung, M. Felmus (1978)
Free amino acid levels in amyotrophic lateral sclerosisAnnals of Neurology, 3
B. Manyam, T. Ferraro, T. Hare (1988)
Cerebrospinal fluid amino compounds in Parkinson's disease. Alterations due to carbidopa/levodopa.Archives of neurology, 45 1
A. Plaitakis, J. Mandeli, Jeffrey Smith, M. Yahr (1988)
PILOT TRIAL OF BRANCHED-CHAIN AMINOACIDS IN AMYOTROPHIC LATERAL SCLEROSISThe Lancet, 331
H. Benveniste, J. Drejer, A. Schousboe, N. Diemer (1984)
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 43
G. Forloni, R. Grzanna, R. Blakely, J. Coyle (1987)
Co‐localization of N‐acetyl‐aspartyl‐glutamate in central cholinergic, noradrenergic, and serotonergic neuronsSynapse, 1
L. Gjessing, P. Gjesdahl, P. Dietrichson, J. Presthus (1974)
Free amino acids in the cerebrospinal fluid in old age and in Parkinson's disease.European neurology, 12 1
B. Hourani, E. Hamlin, T. Reynolds (1971)
Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy.Archives of internal medicine, 127 6
P. Spencer (1987)
Guam ALS/Parkinsonism-Dementia: A Long-Latency Neurotoxic Disorder Caused by “Slow Toxin(s)” in Food?Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 14
M. Zollinger, U. Amsler, K. Do, P. Streit, M. Cuénod (1988)
Release of N‐Acetylaspartylglutamate on Depolarization of Rat Brain SlicesJournal of Neurochemistry, 51
(1982)
B e e amino acids in motor neuron cortex in amyotrophic lateral sclerosis. Experientia Daube JR. EMG in motor neuron diseases
J. Coyle (1983)
Neurotoxic action of kainic acid.Journal of neurochemistry, 41 1
J. Lakke, A. Teelken (1976)
Amino acid abnormalities in cerebrospinal fluid of patients with parkinsonism and extrapyramidal disordersNeurology, 26
J. Krystal (1989)
Psychopharmacology: The Third Generation of ProgressThe Yale Journal of Biology and Medicine, 62
J. Hugon, F. Tabaraud, M. Rigaud, Jean-Michel Vallat, M. Dumas (1989)
Glutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron diseaseNeurology, 39
H. Meltzer (1987)
Psychopharmacology : the third generation of progress
A. Guarda, M. Robinson, L. Ory-Lavollée, G. Forloni, R. Blakely, J. Coyle (1988)
Quantitation of N-acetyl-aspartyl-glutamate in microdissected rat brain nuclei and peripheral tissues: findings with a novel liquid phase radioimmunoassay.Brain research, 427 3
R. Blakely, L. Ory-Lavollée, R. Grzanna, K. Koller, J. Coyle (1987)
Selective immunocytochemical staining of mitral cells in rat olfactory bulb with affinity purified antibodies against N-acetyl-aspartyl-glutamateBrain Research, 402
J. Rothstein, B. Tabakoff (1985)
Glial and neuronal glutamate transport following glutamine synthetase inhibition.Biochemical pharmacology, 34 1
J. Belleroche, A. Recordati, F. Rose (1984)
Elevated levels of amino acids in the CSF of motor neuron disease patients.Neurochemical pathology, 2 1
A. Plaitakis, Evangelos Constantakakis, Jeffrey Smith (1988)
The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosisAnnals of Neurology, 24
Manyam Manyam, Ferraro Ferraro, Hare Hare (1988)
Cerebrospinal fluid amino compounds in Parkinson's diseaseArch Neurol, 45
Recently, the excitatory amino acid neurotransmitter glutamate was implicated in the pathogenesis of a variety of chronic degenerative neurological diseases in humans and animals. This report describes abnormalities in excitatory amino acids in the central nervous system of 18 patients with amyotrophic lateral sclerosis (ALS). The concentration of the excitatory amino acids glutamate and aspartate in the cerebrospinal fluid were increased significantly (p > 0.01) by 100 to 200% in patients with ALS. Similarly, the concentrations of the excitatory neuropeptide N‐acetyl‐aspartyl glutamate and its metabolite, N‐acetyl‐aspartate, were elevated twofold to threefold in the cerebrospinal fluid from the patients. There was no relationship between amino acid concentrations and duration of disease, clinical impairment, or patient age. In the ventral horns of the cervical region of the spinal cord, the level of N‐acetyl‐‐aspartyl glutamate and N‐acetyl‐aspartate was decreased by 60% (p > 0.05) and 40% (p > 0.05), respectively, in 8 patients with ALS. Choline acetyltransferase activity was also diminished by 35% in the ventral horn consistent with motor neuron loss. We conclude that excitatory amino acid metabolism is altered in patients with ALS. Based on neurodegenerative disease models, these changes may play a role in motor neuron loss in ALS.
Annals of Neurology – Wiley
Published: Jul 1, 1990
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.